04 April 2017
DanStem Seminar by Allison Bardin, April 19, 2017, 12:15
Allison Bardin, Curie Institute, Paris Title: Understanding adult stem cells: from lineage decisions to genome instability Place: Nielsine Nielsen auditorium, Mærsk Tower
Allison Bardin, Curie Institute, Paris
Title: Understanding adult stem cells: from lineage decisions to genome instability
19 April 2017, 12:15
Place: Nielsine Nielsen auditorium, Mærsk Tower
Understanding the dual capacity of self-renewal and differentiation is an important aim of regenerative medicine and also has implications for cancer biology. The aim of work is to identify mechanisms important for these processes and ultimately to understand how they function collectively to promote homeostasis of a tissue. To do so, the group is using a simplified model system, the Drosophila intestine which contains around 1000 multipotent intestinal stem cells (Fig. 1). The intestinal stem cells produce the two differentiated cell types required for organ function: the enterocytes and enteroendocrine cells. The differentiated cells are replaced approximately once a week in healthy animals but can be stimulated to rapidly regenerate the intestine upon infection by pathogenic bacteria or treatment with damaging agents (DSS, paraquat). Thus, this is an excellent simple model for mammalian tissues such as the intestine, lung or skin that need to regenerate in response to environmental stimuli.
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