Cell self-organization - 3D systems for growing mini-pancreas in a dish – University of Copenhagen

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15 September 2014

Cell self-organization - 3D systems for growing mini-pancreas in a dish

ORGAN BIOGENESIS

Together with colleagues at Ecole Polytechnique Fédérale de Lausanne in Schwitzerland, DanStem Professor Anne Grapin-Botton has published a review article focused on the currently available systems and models that allow the formation of miniature pancreas in a dish.

The Grapin-Botton laboratory has developed methods for growing mini-pancreas from a few mouse embryonic progenitor/stem cells under 3D conditions in the laboratory. The review discusses the 3D methods developed by them and other groups to grow embryonic or adult pancreatic progenitors from stem cells in 3D, how these techniques were used to address new questions and the promises these models hold.

Models and systems for growing organs in 3D in the laboratory from only a few stem cells or progenitor cells open up new research paths to investigate:

“The 3D systems open up for new types of questions to be addressed. In my work, I am especially interested in how the pancreas develops. The ability to grow mini-pancreatic organs in the lab enables us to study human pancreas development and function in a much more efficient way as well as to develop diabetes models and therapeutic cells,” explains Professor Grapin-Botton

The review article was published online in the scientific journal Stem Cells on September 12, 2014.

Article details: C Greggio, F De Franceschi, A Grapin‐Botton. In Vitro-Produced Pancreas Organogenesis Models In Three Dimensions: Self-Organization From Few Stem Cells Or Progenitors, Stem Cells, September 2014, DOI: 10.1002/stem.1828.

Link to abstract: http://onlinelibrary.wiley.com/doi/10.1002/stem.1828/abstract


Contact: Professor Anne Grapin-Botton, anne.grapin-botton@sund.ku.dk, +45  2115 2863