09 February 2017
Marie Skłodowska-Curie Fellowship to Charlotte Bailey from the Ober group
The 24 months Marie Skłodowska-Curie project, LIVERZAP aims to generate a detailed map of the different cell behaviours driving restoration of liver architecture, by pioneering real-time, in vivo imaging of regeneration in zebrafish.
About the project
The specialised tissue architecture of the liver is crucially important for its essential metabolic functions in the body. The liver has the unique regenerative capacity to restore lost architecture when damaged. However, this remodelling process is compromised in chronic liver disease by scarring and cirrhosis. Often the only treatment is organ transplantation, thus the development of novel therapies is of vital importance. The necessary understanding of the dynamic cell rearrangement driving restoration of liver architecture has been limited by temporally static histological analyses of fixed regenerating tissue.
Charlotte Bailey, The Ober group
Real-time monitoring of the mammalian liver is hindered by tissue opacity and deep organ position, whereas the surface location of the zebrafish liver and larval transparency makes this species uniquely suited for live, in vivo imaging of regeneration. LIVERZAP will generate a detailed map of the different cell behaviours driving restoration of liver architecture by pioneering real-time, in vivo imaging of regeneration in zebrafish.
LIVERZAP aims to produce essential insights into the cellular and molecular mechanisms driving restoration of liver architecture following injury, providing a platform for the long-term development of therapies for human liver pathologies.
Read more about the Marie Skłodowska-Curie actions