20 November 2014
Job opportunity: Postdoctoral Fellowships in Cell and Developmental Biology for the Ober group
The Ober group is looking for two Postdoctoral Fellowships investigating ‘cell migration and tissue assembly in liver organogenesis and regeneration’ are available at The Danish Stem Cell Center (DanStem). The tenure of the positions is initially for two years, with the possibility of extension.
We are recruiting outstanding, ambitious candidates with a strong background in cell and developmental biology to join our group. The overall aim of our work is to understand the cellular and molecular mechanisms of vertebrate organogenesis using the zebrafish liver as a model. We focus on the molecular mechanisms that regulate cell fate decisions in the early foregut, in particular between liver and pancreas, and how subsequent morphogenetic processes, such as cell shape changes and migration, are controlling organ size and position during development and regeneration.
We have recently identified several mutants with unique morphogenesis phenotypes, encoding some of the first factors suggested to control progenitor migration. The proposed projects will focus on the cellular and molecular mechanisms that control how liver progenitors migrate through the cellular 3-D environment to assemble into an organ and the underlying cell- and tissue interactions. A related aspect is to understand how changing mechanical properties and cytoskeletal dynamics of the progenitor cells relate to cell differentiation. To examine these questions we combine state-of-the-art zebrafish genetics and cell biology approaches with high-resolution confocal in vivo imaging.
For more information about the position, and to submit an application, please click HERE