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DanStem Newsletter March 2016
DanStem's Statistics for 2015
Recruiting Junior Group Leaders
In order to expand our research themes and create a synergistic team, we are now in the process of recruiting three junior group leaders in the fields of Pancreatic Cancer, Stem Cell Biology and Bioengineering.
The Scientific Advisory Board visited DanStem
Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors
In a new paper, published in Cell, Volume 163, Issue 7, 17 December 2015, Pages 1663–1677, Professor Bo Porse, and PhD student Felicia Bratt Lauridsen in a collaborative headed by the group of Ido Amit at the Weizmann Institute in Tel Aviv, have used single-cell transcriptomic analysis to demonstrate an unexpected behavior of myeloid progenitors of the bone marrow.
How does the pancreas make branches?
DanStem and StemPhys Professor Anne Grapin-Botton and PhD student Svend Dahl-Jensen, together with Professor Kim Sneppen, The Center for Models of Life at the Niels Bohr Institute, and their research teams made headway in answering the question of how the pancreas forms a branching tree by combining their expertise of stem cell biotechnology and computer simulations.
Grapin-Botton group (2016). Short-range growth inhibitory signals from the epithelium can drive non-stereotypic branching in the pancreas. Physical Biology, 13(1):016007, doi: 10.1088/1478-3975/13/1/016007.
Helin group (2016). DNMT3AR882H mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice. Leukemia, doi:10.1038/leu.2016.29.
Brickman group (2016). Differentiation of Mouse Embryonic Stem Cells into Ventral Foregut Precursors. Current Protocols in Stem Cell Biology, 36:1G.3.1-1G.3.12. doi: 10.1002/9780470151808.sc01g03s36
Kassem group (2016). Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy. Stem Cells International, 20168, doi:10.1155/2016/9601493.
Helin group (2016). A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation. Oncogene, doi:10.1038/onc.2015.504.
Kassem group (2016). CD146/MCAM defines functionality of human bone marrow stromal stem cell populations. Stem Cell Research & Therapy, 7(1), 4, doi:10.1186/s13287-015-0266-z.
Kassem group (2015). Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutations. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, doi:10.1016/j.bbamcr.2015.11.037.
Ferretti group (2015). Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron, 88(6), 1192-1207, doi:10.1016/j.neuron.2015.10.045.
Petersen group (2016). Raising an Antibody Specific to Breast Cancer Subpopulations Using Phage Display on Tissue Sections. Cancer Genomics Proteomics, 13(1), 21-30.
Porse group. Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. Cell, doi: 10.1016/j.cell.2015.11.013. (epub ahead of print: November 25, 2015).
Serup group (2015) Research resource: A dual proteomic approach identifies regulated islet proteins during beta cell mass expansion in vivo. Molecular Endocrinology, me.2015-1208, doi: 10.1210/me.2015-1208.
Ober group (2015). Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. Cell Reports, 13(9), 1828-1841, doi:10.1016/j.celrep.2015.10.055.
Lundbeckfonden Biomedical Grant awarded to Joshua Brickman
Professor Palle Serup in an interview to DR1
Stem cell therapies and diabetes
DanStem Seminar series 2016
Professor Brickman - appointed Deputy Chair for MRC Board
Professor Joshua Brickman from DanStem is appointed a Deputy Chair for the MRC, Molecular & Cellular Medicine Board. The position will start on April 1st, 2016 and will last for three years.
Outreach event at Frederiksberg Gymnasium
The DanStem annual Stem Cell Day will be held on May 3, 2016, Nørre Gymnasium. Approximately twenty scientists are planned to participate in this event, addressing their research to over 100 high school students.
TeachingDuring 2015 DanStem's scientists were involved in teaching six different courses and supervised eight MSc projects. Additionally, together with the SUND departments BMI and ICMM DanStem offered workshop on didactic training for PhD students, postdocs and young faculty. Young scientists, who did not have the opportunity to teach on undergraduate level in 2015 were encouraged to participate in the “Stem Cell Day” outreach event for 160 high school students at Christianshavns Gymnasium, read more...
See our Strategy for Education HERE
The Copenhagen BioScience PhD programmeThe Copenhagen Bioscience PhD programme, is a new initiative that offers talented students the opportunity to launch their careers in the Novo Nordisk Foundation research center cluster. Sixteen students will be recruited annually through the programme. More than 300 candidates have applied, of which third choose DanStem as their preferred center. 32 top students will be invited for interviews, to take place in Denmark in April 2016.
The Stem Cell Niche conference
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Sendt d. 23 March 2016