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Joshua Mark BrickmanProfessor of Stem Cell and Developmental Biology |
Awards and Honours
Joshua Brickman is the recipient of several awards and grants including a Wellcome Trust Career Development Fellowship, a Human Frontiers in Science Program (HFSP) Long Term Fellowship and a Harvard University, Derek Bock Centre Award for excellence in Teaching. In total, Brickman has been awarded research grants for over £ 5 millions.
Research Profile
The Brickman group aims to understand the mechanism by which sequence specific DNA binding proteins guide early embryo and embryonic stem cell differentiation into mesendoderm. Mesendoderm is an embryonic tissue that both patterns the anterior-posterior neural axis and gives rise to organs such as the liver and pancreas.
The group's research is particularly focused on the developmentally important and relatively non-specific homeodomain transcription factors and the mechanism by which they can induce highly specific responses in both mesendoderm patterning and induction. We seek to understand the mechanism by which these proteins influence the output of specific signalling events to guide key cell fate decisions both in vivo and in vitro.
Key Recent Discoveries
Functional Heterogeneity of Embryonic Stem Cells Revealed Through Translational Amplification of an Early Endodermal Transcript.
Canham, M., Sharov, A., Ko, M., and J.M. Brickman, PLoS Biology. 2010, 8 (6): e1000379
-See also comment: “Cell lineage determination in state space: a systems view brings flexibility to dogmatic canonical rules,” PLoS Biology, 2010 vol. 8 (5): e1000380
Expression-Independent Gene Trap Vectors for Random and Targetted mutagenesis in embryonic stem cells.
Tsakiridis, A., Tzouanacou, E., Rahman, A., Axton, R., Wilson, V., Forrester, L., J. M. Brickman, Nucl Acid Res, 2009 37(19): e129.
Differentiation of Embryonic Stem Cells into Anterior Definitive Endoderm.
Livingi, A., Villegas, S.N., Oikonomopoulou, I., Rahman, A., Morrison, G., M., and J. M. Brickman, Current Protocols in Stem Cell Biology, 2009
Micropshere-based tagging and molecular delivery in embryonic stem cells. Biomaterials
Tsakiridis, A., Alexander, L.M., Gennet, N., Livigni, A., Bella,, A., Sanchez-Martin, R., M., Li, M., Bradley, M., and J.M. Brickman, 2009 30(29):5853-61.
Anterior Definitive Endoderm from ES cells reveals a novel role for FGF signaling.
Morrison, G., M., Oikonomopoulou, I., Portero, R. and J.M. Brickman, Cell Stem Cell, 2008 3(4): p402-415
-See also comment: Expandable Endodermal Progenitors: New Tools to Explore Endoderm and Its Derivatives. Cell Stem Cell, 2008, 3(4): p355-6