Joshua M. Brickman
Professor of Stem Cell and Developmental Biology
Link to the Brickman Laboratory Homepage
Josh Brickman has a background in molecular biology and gene regulation. From a PhD in transcription he trained in developmental biology as a post-doctoral fellow, working in early mouse, and Xenopus, as well as cultivating embryonic stem cells as a model for developmental biology. He began his own lab with research projects bridging early development in multiple models systems with ES cells in a hybrid approach aimed at understanding conserved mechanisms of pluripotency and self renewal.
He currently seeks to understand how transcription factors regulate cell fate choice in ES cells and early embryos. More specifically, Professor Brickman’s and his group investigate the basis for transcriptional priming and commitment in ES cells and early in the specification of the endoderm lineage. They hope to understand the relevance of these priming events to stem and progenitor cell potency.
Awards and Honours
Josh Brickamn is the recipient of several personal awards and numerous grants including, a Human Frontiers Science Program (HFSP) Long Term Fellowship. Wellcome Trust Research Career Development Fellowship and MRC Senior Non Clinical Fellowship. He is also coordinator of an HFSP program grant and serves on several advisory and editorial boards.
Key Recent Discoveries
Laing, Adam F., Sally Lowell & Joshua M. Brickman (2015). Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression. Developmental Biology, 397(1), 56-66, doi: 10.1016/j.ydbio.2014.10.007. (epub ahead of print October 23, 2014)
Hamilton, William B. & Joshua M. Brickman (2014). Erk Signaling Suppresses Embryonic Stem Cell Self-Renewal to Specify Endoderm. Cell Reports, 9(6), 2056-2070, doi:10.1016/j.celrep.2014.11.032.
Morgani, Sophie M., Maurice A. Canham, Jennifer Nichols, Alexei A. Sharov, Rosa Portero Migueles, Minoru S. H. Ko & Joshua M. Brickman (2013). Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions. Cell Reports, 3(6), 1945-1957, doi:10.1016/j.celrep.2013.04.034.
Livigni, Alessandra, Hanna Peradziryi, Alexei A. Sharov, Gloryn Chia, Fella Hammachi, Rosa Porter Migueles, Woranop Sukparangsi, Salvatore Pernagallo, Mark Bradley, Jennifer Nichols, Minoru S. H. Ko & Joshua M. Brickman (2013). A Conserved Oct4/POUV-Dependent Network Links Adhesion and Migration to Progenitor Maintenance. Current Biology, 23(22), 2233-2244, doi:10.1016/j.cub.2013.09.048.
Villegas, S. Nahuel, Michaela Rothova, Martin E. Barrios-Llerena, Maria Pulina, Anna-Katerina Hadjantonakis, Thierry Le Bihan, Sophie Astrof & Joshua M. Brickman (2013). PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix. Elife, 2, doi:10.7554/eLife.00806.001.
Hammachi, Fella, Gillian M. Morrison, Alexei A. Sharov, Alessandra Livigni, Santosh Narayan, Eirini P. Papapetrou, James O'Malley, Keisuke Kaji, Minoru S. H. Ko, Mark Ptashne & Joshua M. Brickman (2012). Transcriptional Activation by Oct4 Is Sufficient for the Maintenance and Induction of Pluripotency. Cell Reports, 1(2), 99-109, doi:10.1016/j.celrep.2011.12.002.
Canham, Maurice A., Alexei A. Sharov, Minoru S.H. Ko, & Joshua M. Brickman (2010). Functional Heterogeneity of Embryonic Stem Cells Revealed through Translational Amplification of an Early Endodermal Transcript. Plos Biology, 8(5), e1000379, doi:10.1371/journal.pbio.1000379.
Morrison, Gillian M., Ifigenia Oikonomopoulou, Rosa Portero Migueles, Shamit Soneji, Alessandra Livigni, Tariq Enver & Joshua M. Brickman (2008). Anterior Definitive Endoderm from ESCs Reveals a Role for FGF Signaling. Cell Stem Cell, 3(4), 402-415, doi: 10.1016/j.stem.2008.07.021.