Professor of Developmental Biology
Link to the Grapin-Botton Laboratory Homepage
Anne Grapin-Botton has a background in developmental biology and initially studied nervous system and endoderm patterning. Her laboratory is currently focused on pancreas development with the overall goals of understanding how pancreatic cells differentiate during embryogenesis, and determining what limits the pancreatic cells’ regeneration in adults. More specifically, Professor Grapin-Botton and her group investigate the impact of the cellular and organ architecture on the cells’ fate choices, especially the role of the planar cell polarity pathway and its interactions with canonical Wnt signaling.
Awards and Honours
Anne Grapin-Botton is the recipient of several awards and grants including, a Human Frontiers Science Program (HFSP) Long Term Fellowship. Professor Grapin-Botton is a Beta Cell Biology Consortium Investigator, and also serves on the editorial board of the journal Mechanisms and Development.
Key Recent Discoveries
Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.
Cortijo, C., Gouzi, M., Tissir, F. and Grapin-Botton, A. (2012) Cell Reports. 2(6):1593-606.
Mechanisms of pancreas progenitor maintenance by Ptf1a are revealed by RNA profiling and ChIP sequencing.
Thompson, N., Gésina, E., Scheinert, P., Bucher, P. and Grapin-Botton, A. (2012) Mol Cell Biol. 32(6):1189-99.
Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associate with cystic renal dysplasia.
R-C Kraus, M., Clauin, S., Pfister,Y., Di Maïo, M., Ulinski, T., Constam, D., Bellanné-Chantelot, C. and Grapin-Botton, A. (2012) Human Mutation, 33 (1):86–90.
Temporal control of Neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cells.
Johansson, K., Dursun, U., Jordan, N., Gu, G., Beermann, F., Gradwohl, G. and Grapin-Botton, A. (2007) Developmental Cell 12:457-65.