Bo Porse is Head of the Finsen Laboratory at Copenhagen University Hospital, Group Leader at the Biotech Research and Innovation Centre (BRIC) and Professor in Molecular Oncology at the Department of Clinical Medicine at the University of Copenhagen.
Awards and Honours
Bo Porse has received several accolades for his work including a Young Research Leader Stipend from the Danish Medical Research Council and the Junior Research Prize from the Danish Cancer Society.
Bo Porse and his research group are studying cancer relevant processes from a stem cell centric viewpoint. His overarching research goal is to define differences and similarities between normal and cancerous stem cells, with the hope of facilitating therapeutic targeting of the latter. His work is currently concentrating on characterizing genes and pathways that govern the self renewal of normal hematopoietic stem cells, as these are often high-jacked by leukemic stem cells. In particular, his focus is on transcription factors and RNA processing factors regulating self renewal in normal hematopoietic stem cells as these are frequently de-regulated in leukemic stem cells. Recently, his group also embarked on large-scale collaborative gene expression profiling studies of AML patients, with the aim of identifying genes and pathways that contribute to the maintenance of cancer stem cells in this disease.
Key Recent Discoveries
Willer, Anton, Janus S. Jakobsen, Ewa Ohlsson, Nicolas Rapin, Johannes Waage, M. Billing, Lars Bullinger, S. Karlsson & Bo T. Porse (2014). TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia. Leukemia, doi: 10.1038/leu.2014.307. (epub ahead of print on November 21, 2014)
Hasemann, Marie S., Felicia K. B. Lauridsen, Johannes Waage, Janus S. Jakobsen, Anne-Katrine Frank, Mikkel B. Schuster, Nicolas Rapin, Frederik O. Bagger, Philipp S. Hoppe, Timm Schroeder & Bo T. Porse (2014). C/EBP alpha Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors. Plos Genetics, 10(1), e1004079, doi:10.1371/journal.pgen.1004079.
Ohlsson, Ewa, Marie Sigurd Hasemann, Anton Willer, Felicia Kathrine Bratt Lauridsen, Nicolas Rapin, Johan Jendholm & Bo T. Porse (2014). Initiation of MLL-rearranged AML is dependent on C/EBP alpha. Journal of Experimental Medicine, 211(1), 5-13, doi:10.1084/jem.20130932.
Jakobsen, Janus Schou, Johannes Waage, Nicolas Rapin, Hanne Cathrine Bisgaard, Fin Stolze Larsen & Bo T. Porse (2013). Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries. Genome Research, 23(4), 592-603, doi:10.1101/gr.146399.112.
Weischenfeldt, Joachim, Johannes Waage, Geng Tian, Jing Zhao, Inge Damgaard, Janus Jakobsen, Karsten Kristiansen, Anders Krogh, Jun Wang & Bo T. Porse (2012). Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns. Genome Biology, 13(5), R35, doi: 10.1186/gb-2012-13-5-r35.
Weischenfeldt, Joachim, Inge Damgaard, David Bryder, Kim Theilgaard-Monch, Lina A. Thoren, Finn Cilius Nielsen, Sten Eirik W. Jacobsen, Claus Nerlov & Bo T. Porse (2008). NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes & Development, 22(10), 1381-1396, doi:10.1101/gad.468808.