Jakub Sedzinski – University of Copenhagen

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DanStem > Staff > Sedzinski Lab > Jakub Sedzinski

Jakub Sedzinski

Associate Professor of Stem Cell Biology

jakub.sedzinski@sund.ku.dk

Link to the Sedzinski Laboratory Homepage

Research Profile

Jakub’s education and training have been cross-disciplinary, spanning topics in biology, biophysics, and computational biology. After undergraduate studies in Molecular Biology at the University of Wroclaw in Poland, he completed a PhD at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden with Professor Ewa Paluch. There he became fascinated with biophysical approaches to cell biology and investigated the basics mechanisms of cytokinesis. He discovered that cytokinesis is inherently unstable and that imbalance in contractile forces compromises cytokinetic furrow positioning.

He then received a prestigious fellowship from European Molecular Biology Organization (EMBO) to carry out research at The University of Texas at Austin in the laboratory of Prof. John Wallingford. Here, Jakub continued his training in mechanics and regulation of cell shape, but in the context of developing embryos. His postdoctoral work defined a novel cell behavior - apical emergence, which describes the broad spectrum of cellular processes resulting in integration of a progenitor cell with an existing epithelium.

The Sedzinski laboratory at the Danish Stem Cell Center (DanStem) is now focused on understanding the molecular and mechanical mechanisms of epithelial cell renewal in vivo.

About Jakub Sedzinski

Curriculum Vitae:

March 2017: Associate Professor, Group Leader
University of Copenhagen, Denmark
Danish Stem Cell Center (DanStem)

June 2016 - March 2017: Research Associate
The University of Texas at Austin, USA
Advisor: Prof. John Wallingford

September 2011 - June 2016: Post-Doctoral Training
The University of Texas at Austin, USA
Advisor: Prof. John Wallingford

December 2010 - August 2011: Post-Doctoral Training
The Max Planck Institute of Molecular Cell Biology and Genetic, Dresden, Germany
Advisor: Prof. Ewa Paluch

September 2006 - December 2010: Doctorate in Biology
The Max Planck Institute of Molecular Cell Biology and Genetic, Dresden, Germany
Advisor: Prof. Ewa Paluch

July 2005 - June 2006: MSc in Biology
The University of Wroclaw, Poland
Advisor: Prof. Jan Szopa

September 2004 - June 2005: Visiting scientist
The Max Planck Institute of Molecular Plant Physiology, Golm, Germany
Advisor: Dr. Rita Zrenner

September 2001 - July 2004: BSc in Biology
July 2004 The University of Wrocalw, Poland
Advisor: Prof. Jan Szopa

Selected Publications

Sedzinski, J., E. Hannezo, F. Tu, M. Biro & J. B. Wallingford (2017). RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells. J Cell Sci, 130(2), 420-428, doi:10.1242/jcs.194704.

Sedzinski, J., E. Hannezo, F. Tu, M. Biro & J. B. Wallingford (2016). Emergence of an Apical Epithelial Cell Surface In Vivo. Developmental Cell, 36(1), 24-35, doi:10.1016/j.devcel.2015.12.013.

Turk, E., A. A. Wills, T. Kwon, J. Sedzinski, J. B. Wallingford & T. Stearns (2015). Zeta-Tubulin Is a Member of a Conserved Tubulin Module and Is a Component of the Centriolar Basal Foot in Multiciliated Cells. Current Biology, 25(16), 2177-2183, doi:10.1016/j.cub.2015.06.063.

Sedzinski, J., M. Biro, A. Oswald, J. Y. Tinevez, G. Salbreux & E. Paluch (2011). Polar actomyosin contractility destabilizes the position of the cytokinetic furrow. Nature, 476(7361), 462-U119, doi:10.1038/nature10286.