04 October 2016
Regional tumour glutamine supply affects chromatin and cell identity
Højfeldt, Jonas W. & Kristian Helin (2016). Regional tumour glutamine supply affects chromatin and cell identity. Nature Cell Biology, 18(10), 1027-1029, doi:10.1038/ncb3414.
Limited perfusion of solid tumours produces a nutrient-deprived tumour core microenvironment. Low glutamine levels in the tumour core are now shown to lead to reduced levels of α-ketoglutarate and decreased histone demethylase activity, thereby promoting a less differentiated and more therapy-resistant state of the tumour cells.