11 March 2016
Short-range growth inhibitory signals from the epithelium can drive non-stereotypic branching in the pancreas.
Dahl-Jensen, Svend, Manuel Figueiredo-Larsen, Anne Grapin-Botton & Kim Sneppen (2016). Short-range growth inhibitory signals from the epithelium can drive non-stereotypic branching in the pancreas. Physical Biology, 13(1):016007, doi: 10.1088/1478-3975/13/1/016007.
Many organs such as the vasculature, kidney, lungs, pancreas and several other glands form ramified networks of tubes that either maximize exchange surfaces between two compartments or minimize the volume of an organ dedicated to the production and local delivery of a cell-derived product. The structure of these tubular networks can be stereotyped, as in the lungs, or stochastic with large variations between individuals, as in the pancreas. Read more