Grapin-Botton Lab: publications – University of Copenhagen

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Grapin-Botton Lab - List of publications

Martin, D., Kim, Y.H., Sever, D., Mao, C.A., Haefliger, J.A.and  Grapin-Botton, A. (2015) REST represses a subset of the pancreatic endocrine differentiation program. Dev Biol. 405:316-27.

Ober, E.A. and  Grapin-Botton A. (2015) At new heights - endodermal lineages in development and disease. Development 142(11):1912-1917.

Berclaz, C., Pache, C., Bouwens, A., Szlag, D., Lopez, A., Joosten, L., Ekim, S., Brom, M., Gotthardt, M., Grapin-Botton, A. and Lasser, T.. (2015) Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers. Sci Rep. 5:10385.

Grapin-Botton, A., Seymour, P.A. and Gradwohl, G. (2015) Pairing-up SOX to kick-start beta cell genesis. Diabetologia 58:859-61.

Kim, Y. H., List Larsen, H., Rué, P.,  Lemaire, L.A.,  Ferrer, J. and  Grapin-Botton, A.  (2015) Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas. PLOS Biology, 13:e1002111.

Lemaire, L.A, Goulley, J., Kim, Y.H., Carat, S., Jacquemin, P.,   Rougemont, J., Constam, D.  and Grapin-Botton, A. (2015) Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal homeostasis. Development, 142:858-70.

Rué, P., Kim, Y.H., List Larsen, H., Grapin-Botton, A., Martinez Arias, A.  (2014) A framework for the analysis of symmetric and asymmetric divisions in developmental processes. BIORXIV/2014/010835.

Willet, S.G., Hale, M.A., Grapin-Botton, A., Magnuson, M.A., MacDonald, R.J., Wright, C.V. (2014) Dominant and context-specific control of endodermal organ allocation by Ptf1a. Development. 141(22):4385-94.

Greggio, C., De Franceschi, F. and Grapin-Botton, A. (2014) In Vitro-Produced Pancreas Organogenesis Models In Three Dimensions: Self-Organization From Few Stem Cells Or Progenitors. Stem Cells. 33:8-14.

Greggio, C., De Franceschi, F., Figueiredo-Larsen, M. and Grapin-Botton, A. (2014) In vitro pancreas organogenesis from dispersed mouse embryonic progenitors. J Vis Exp. 19;(89). doi: 10.3791/51725.

Hanotel, J., Bessodes, N., Thélie, A., Hedderich, M., Parain, K., Van Driessche, B., Brandão Kde, O., Kricha, S., Jorgensen, M.C., Grapin-Botton, A., Serup, P., Van Lint, C., Perron, M., Pieler, T., Henningfeld, K.A. and Bellefroid, E.J. (2014) The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbpj downstream target that suppresses glutamatergic and promotes GABAergic neuronal fate in the dorsal neural tube. Dev Biol. 386:340-57.

Greggio, C., De Franceschi, F., Figueiredo-Larsen, M., Gobaa, S., Ranga, A., Semb, H., Lutolf, M. and Grapin-Botton, A. (2013) Artificial three-dimensional niches deconstruct pancreas development in vitro. Development, 140:4452-62.

Kartikasari, A.E., Zhou, J.X., Kanji, M.S., Chan, D.N., Sinha, A., Grapin-Botton, A., Magnuson, M.A., Lowry, W.E. and Bhushan, A. (2013) The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation. EMBO J. 32:1393-408.

Qu, X., Afelik, S., Jensen, J.N., Bukys, M.A., Kobberup, S., Schmerr, M., Xiao, F., Nyeng, P., Veronica Albertoni, M., Grapin-Botton, A. and Jensen J. (2013) Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment. Dev Biol. 376:1-12.

Cortijo, C., Gouzi, M., Tissir, F. and Grapin-Botton, A. (2012) Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Reports 2:1593-606. 

Serup, P., Gustavsen, C., Klein, T., Potter, L.A., Lin, R., Mullapudi, N., Wandzioch, E., Hines, A., Davis, A., Bruun, C., Engberg, N., Petersen, D.R., Peterslund, J.M., Macdonald, R.J., Grapin-Botton, A., Magnuson, M.A. and Zaret, K.S. (2012) Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice. Dis. Model Mech. 5(6):956-66.

Choi, E., Kraus, M.R.C., Lemaire L.A., Yoshimoto, M., Vemula, S, Potter, L.A., Manduchi, E., Stoeckert, C.J., Grapin-Botton, A. and Magnuson, M.A. (2012) Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells 30(10):2297-30.  

Kraus, M.R. and Grapin-Botton, A. (2012) Patterning and shaping the endoderm in vivo and in culture. Curr Opin Genet Dev. 22(4):347-53.

Berclaz, C., Goulley, J., Villiger, M., Pache, C., Bouwens, A., Martin-Williams, E., Van de Ville, D., Davison, A.C., Grapin-Botton, A. and Lasser, T. (2012) Diabetes imaging-quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy. Biomed Opt Express 3(6):1365-80.

Shih, H.P., Kopp, J.L., Sandhu, M., Dubois, C.L., Seymour, P.A., Grapin-Botton, A. and Sander, M. (2012) A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development 139(14):2488-99.

Thompson, N., Gésina, E., Scheinert, P., Bucher, P. and Grapin-Botton, A. (2012) Mechanisms of pancreas progenitor maintenance by Ptf1a are revealed by RNA profiling and ChIP sequencing. Mol Cell Biol. 32(6):1189-99.  

Boutant M, Ramos OH, Tourrel-Cuzin C, Movassat J, Ilias A, Vallois D, Planchais J, Pégorier JP, Schuit F, Petit PX, Bossard P, Maedler K, Grapin-Botton A and Vasseur-Cognet M. (2012) COUP-TFII Controls Mouse Pancreatic β-Cell Mass through GLP-1-β-Catenin Signaling Pathways. PLoS One 7(1):e30847.

R-C Kraus, M., Clauin, S., Pfister,Y., Di Maïo, M., Ulinski, T., Constam, D., Bellanné-Chantelot, C. and Grapin-Botton, A. (2011) Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associate with cystic renal dysplasiaHuman  Mutation 33(1):86-90. IF 6, 1 cit

Gouzi, M.; Kim, Y.H., Katsumoto, K., Johansson, K. and Grapin-Botton, A. (2011) Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development. Dev. Dyn. 240(3):589-604.

Villiger, M, Goulley, J, Martin-Williams, EJ, Grapin-Botton, A and Lasser, T. (2010) Towards high resolution optical imaging of beta cells in vivo. Curr Pharm Des. 16:1595-608.

Bayha E, Jørgensen MC, Serup P and Grapin-Botton A. (2009) Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. PLoS One 4:e5845.

Villiger, M., Goulley, J., Friedrich, M., Grapin-Botton, A., Meda, P., Lasser, T. and Leitgeb, R.A. (2009) In vivo imaging of endocrine islets with extended focus Optical Coherence Microscopy. Diabetologia 52:1599-607.

Grapin-Botton, A. (2008) Endoderm specification- In StemBook.

Johansson, K., Dursun, U., Jordan, N., Gu, G., Beermann, F., Gradwohl, G. and Grapin-Botton, A. (2007) Temporal control of Neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cells. Developmental Cell 12:457-65.

Grapin-Botton, A., Heimberg, H. and Lemaigre, F. (2007) The genetic programme of pancreatic beta-cells: basic science for the development of beta-cell therapy. Workshop on programming pancreatic beta-cells. EMBO Rep. 8:322-6.

Grapin-Botton, A. and Constam, D. (2012) Evolution of the mechanisms and molecular control of endoderm formation. Mech Dev. 124:253-78.

Dessimoz, J.,Opoka, R., Kordich, J.J., Grapin-Botton, A. and Wells, J.M. (2006) FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo. Mechanisms of Development, 123, 42-45.

Dessimoz, J. and Grapin-Botton, A. (2006) Pancreas development and cancer: Wnt/beta-catenin at issue... Cell Cycle. 5:7-10.

Dessimoz, J., Bonnard, C., Huelsken, J. and Grapin-Botton, A. (2005) Pancreas-specific deletion of b-catenin reveals Wnt-dependent and Wnt-independent functions during development. Current Biology 15:1677-83.

Grapin-Botton, A. (2005) Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis. Int J Dev Biol. 49:335-47

Grapin-Botton, A. (2005) Ductal cells of the pancreas. Int. J. Biochem. Cell Biol. 37:504-510.

Grapin-Botton, A. and Constam, D. (2004) Endoderm development.  Gastrulation. Cold Spring Harbor Laboratory Press. Claudio Stern Editor.

Maya Kumar, Nathalie Jordan, Doug Melton and Anne Grapin-Botton (2003) Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev. Biol. 259:109-22.

Johansson, K. and Grapin-Botton, A.  (2002) Development and diseases of the pancreas. Clin. Genet. 62:14-23.

Grapin-Botton, A. (2002) Les étapes du développement du pancréas: des pistes pour le traitement du diabète. Médecine/Sciences 18:467-473.

Ladjali-Mohammedi, K., Grapin-Botton, A., Bonnin, M.A., Le Douarin, N.M. (2001) Distribution of HOX genes in the chicken genome reveals a new segment of conservation between human and chicken. Cytogenet Cell Genet. 92:157-61.

Grapin-Botton, A. , Majithia, A. R. and Melton, D.M. (2001). Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev., 15, 444-454.

Grapin-Botton, A. and Melton, D.M. (2000). Endoderm development : from patterning to organogenesis. Trends in Genetics 16, 124-130.

Grapin-Botton, A., Cambronero, F., Weiner, H., Bonnin, M.-A., Puelles, L. and Le Douarin, N.M. (1999). Patterning signals acting in the spinal cord override the organizing activity of the isthmus.   Mech. Dev. 84, 41-53.

Couly, G., Grapin-Botton, A., Coltey, P., Ruhin, B. and Le Douarin, N.M. (1998). Determination of the identity of the derivatives of the cephalic neural crest : incompatibility between Hox-gene expression and lower jaw development.  Development 125, 3445-59.

Nataf, V., Grapin-Botton, A., Champeval, D., Amemiya, A.,Yanagisawa, A. and N.M. Le Douarin, N.M. (1998)The expression patterns of endothelin-A receptors and endothelin 1 in the avian embryo. Mech. Dev. 75, 157-61.

Mager, A-M., Grapin-Botton, A., Ladjali, K., Meyer, D., Wolff, C-M., Stiegler, P., Bonnin, M.-A., and Remy, P. (1998). The avian Fli gene is specifically expressed in a subset of neural crest cells giving rise to mesenchyme. Int. J. Dev. Biol. 42, 561-72.

Grapin-Botton, A., Bonnin, M.-A. . Sieweke, M. and Le Douarin, N.M. (1998) Defined concentrations of a posteriorizing signal are critical for MafB/Kreisler segmental expression in the hindbrain. Development, 125, 1173-1181.

Eichmann, A., Sieweke, M., Grapin-Botton, A., Kelly, L., Graf, T. and Le Douarin, N.M. (1997) The expression pattern of MafB/Kr gene in birds and mice reveals that the kreisler phenotype does not represent a null mutant. Mech. Dev. 65, 111-122.

Le Douarin, N.M. and Grapin-Botton, A. (1997) Contrôle génétique du développement du rhombencéphale par les gènes Hox étudié chez l'embryon d'oiseau par la méthode des chimères caille-poulet. C.R. Soc. Biol. 191, 29-42.

Grapin-Botton, A., Bonnin, M.-A. and Le Douarin, N.M. (1997). Hox gene induction in the neural tube depends on three parameters: competence, signal supply and paralogue group. Development 124 (4), 849-859.

Couly, G., Grapin-Botton, A., Coltey, P. and Le Douarin, N.M. (1996). The regeneration of the cephalic neural crest, a problem revisited: the regenerating cells originate from the contralateral or from the anterior and posterior neural fold. Development 122, 3393-3407.

Le Douarin, N.M., Grapin-Botton, A. and Catala, M. (1996). Patterning of the neural primordium in the avian embryo. Seminars in Cell and Dev. Biol. 7, 157-167.

Grapin-Botton, A., Bonnin, M.-A., McNaughton, L.A., Krumlauf, R. and Le Douarin, N.M. (1995). Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications. Development 121, 2707-2721.