Publications – University of Copenhagen

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Publication List – The Danish Stem Cell Center (DanStem)

2017

Dong, Xue, Wilmina N. Landford, James Hart, Maurizio Risolino, Omer Kaymakcalan, Julia Jin, Yoshiko Toyoda, Elisabetta Ferretti, Licia Selleri & Jason A. Spector (2017). Towards Microsurgical Correction of Cleft Lip Ex Utero via Restoration of Craniofacial Developmental Programs. Plastic and Reconstructive Surgery ():, MAR 2017, doi: 10.1097/PRS.0000000000003417.

Ameri, Jacqueline, Rehannah Borup, Christy Prawiro, Cyrille Ramond, Karen A. Schachter, Raphael Scharfmann & Henrik Semb (2017). Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors. Cell Reports,19,36-49, doi: 10.1016/j.celrep.2017.03.032. 

Dahl-Jensen, Svend & Anne Grapin-Botton (2017). The physics of organoids: a biophysical approach to understanding organogenesis. Development,144, 946-951, doi: 10.1242/dev.143693. 

Martin, David & Anne Grapin-Botton (2017). The Importance of REST for Development and Function of Beta Cells. Frontiers in Cell and Developmental Biology, 5(12), doi:10.3389/fcell.2017.00012.

Grapin-Botton, Anne & Palle Serup (2017). Parsing the Pancreas. The New England Journal of Medicine, 376(9), 886-888, doi:10.1056/NEJMcibr1616217.

Horn, Signe, Jeannette S. Kirkegaard, Soraya Hoelper, Philip A. Seymour, Claude Rescan, Jens H. Nielsen, Ole D. Madsen, Jan N. Jensen, Marcus Krüger, Mads Grønborg & Jonas Ahnfelt-Ronne (2017). Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Celll Mass Expansion In Vivo. Mol Endocrinol, 30(1), 133-143, doi:10.1210/me.2015-1208.

Ben-Othman, Nouha, Andhira Vieira, Monica Courtney, Fabien Record, Elisabet Gjernes, Fabio Avolio, Biljana Hadzic, Noémie Druelle, Tiziana Napolitano, Sergi Navarro-Sanz, Serena Silvano, Keith Al-Hasani, Anja Pfeifer, Sandra Lacas-Gervais, Gunter Leuckx, Laura Marroqui, Julien Thévenet, Ole Dragsbaek Madsen, Decio Laks Eizirik, Harry Heimberg, Julie Kerr-Conte, François Pattou, Ahmed Mansouri & Patrick Collombat (2017). Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis. Cell, 168(1-2), 73-85, doi:10.1016/j.cell.2016.11.002.

Mohammad, Faizaan, Simon Weissmann, Benjamin Leblanc, Deo P. Pandey, Jonas W. Højfeldt,  Itys Comet, Chunqin Zheng, Jens Vilstrup Johansen, Nicolas Rapin, Bo T. Porse, Andrey Tvardovskiy, Ole N. Jensen, Nagore G. Olaciregui, Cinzia Lavarino, Mariona Suñol, Carmen de Torres, Jaume Mora, Angel M. Carcaboso & Kristian Helin (2017). EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas. Nature Medicine, 1-12, doi:10.1038/nm.4293. 

Lonowski, Lindsey A., Yoshiki Narimatsu, Anjum Riaz, Catherine E. Delay, Zhang Yang, Francesco Niola, Katarzyna Duda, Elke A. Ober, Henrik Clausen, Hans H. Wandall, Steen H. Hansen, Eric P. Bennett & Morten Frödin (2017). Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis. Nature Protocols, 12(3), 581-603, doi:10.1038/nprot.2016.165.

Migueles, Rosa Portero, Louise Shaw, Neil P. Rodrigues, Gillian May, Korinna Henseleit, Kathryn G. V. Anderson, Hakan Goker, C. Michael Jones, Marella F.T.R. de Bruijn, Joshua M. Brickman & Tariq Enver (2017). Transcriptional Regulation of Hhex in Hematopoiesis and Hematopoietic Stem Cell Ontogeny. Developmental Biology,1-29, doi:10.1016/j.ydbio.2016.12.021.

Jafari, Abbas, Diyako Qanie, Thomas L. Andersen, Yuxi Zhang, Li Chen, Benno Postert, Stuart Parsons, Nicholas Ditzel, Sundeep Khosla, Harald Thidemann Johansen, Per Kjærsgaard-Andersen, Jean-Marie Delaisse, Basem M. Abdallah, Daniel Hesselson, Rigmor Solberg & Moustapha Kassem (2017). Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis. Stem Cell Reports, 8, 1-14, doi:10.1016/j.stemcr.2017.01.003.

Larsen, Hjalte List & Anne Grapin-Botton (2017). The molecular and morphogenetic basis of pancreas organogenesis. Semin Cell Dev Biol, 1-18, doi:10.1016/j.semcdb.2017.01.005.

Hamilton, William B. & Joshua M. Brickman (2017). Surveillance for Secure Differentiation. Cell Stem Cell, 20(1), 3-5, doi:10.1016/j.stem.2016.12.011.

Hopkinson, Branden M., Marie C. Klitgaard, Ole William Petersen, René Villadsen, Lone Rønnov-Jessen & Jiyoung Kim (2017). Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype. Oncotarget,1-14, doi:10.18632/oncotarget.14554.

Sørensen, Karen Marie Juul, Theresa Meldgaard, Connie Jenning Melchjorsen, Agla J. Fridriksdottir, Henrik Pedersen, Ole William Petersen & Peter Kristensen (2017). Upregulation of Mrps18a in breast cancer identified by selecting phage antibody libraries on breast tissue sections. BMC Cancer, 17(1):19, 1-11, doi:10.1186/s12885-016-2987-5. 

2016

Abdallah, Basem M., Florence Figeac, Kenneth H. Larsen, Nicholas Ditzel, Pankaj Keshari, Adiba Isa, Abbas Jafari, Thomas L. Andersen, Jean- Marie Delaisse, Yoshio Goshima, Toshio Ohshima & Moustapha Kassem (2016). CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling. Journal of Bone Mineral Research, 1-31,doi:10.1002/jbmr.3069

Stunnenberg, Henrik G., The International Human Epigenome Consortium, Martin Hirst (2016). The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. Cell, 167(5), 1145-1149, doi: 10.1016/j.cell.2016.11.007. 

Laugesen, Anne, Jonas Westergaard Højfeldt & Kristian Helin (2016). Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and CancerCold Spring Harb Perspect Med, doi:10.1101/cshperspect.a026575.

Brickman, Joshua M. & Palle Serup (2016). Properties of embryoid bodies. Wiley Interdiscip Rev Dev Biol, doi:10.1002/wdev.259.

Berclaz, Corinne, Daniel Szlag, David Nguyen, Jérôme Extermann, Arno Bouwens, Paul J. Marchand, Julia Nilsson, Anja Schmidt-Christensen, Dan Holmberg, Anne Grapin-Botton & Theo Lasser (2016). Label-free fast 3D coherent imaging reveals pancreatic islet micro-vascularization and dynamic blood flow. Biomed Opt Express, 7(11), 4569-4580, doi:10.1364/boe.7.004569

Cooper, Sarah, Anne Grijzenhout, Elizabeth Underwood,  Katia Ancelin, Tianyi Zhang, Tatyana B. Nesterova, Burcu Anil-Kirmizitas, Andrew Bassett, Susanne M. Kooistra, Karl Agger, Kristian Helin, Edith Heard & Neil Brockdorff (2016). Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nature Communications, 1-8, doi:10.1038/ncomms13661.

Morsing, Mikkel, Marie Christine Klitgaard, Abbas Jafari, René Villadsen, Moustapha Kassem, Ole William Petersen & Lone Rønnov-Jessen (2016). Evidence of two distinct functionally specialized fibroblast lineages in breast stroma. Breast Cancer Research, 18:108, 1-11, doi:10.1186/s13058-016-0769-2

Cayuso, Jordi, Aliaksandr Dzementsei, Johanna C Fischer, Gopal Karemore, Sara Caviglia, Josefin Bartholdson, Gavin J Wright & Elke A Ober (2016). EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality. Developmental Cell, 39(3), 316-328, doi:10.1016/j.devcel.2016.10.009.

Illingworth, Robert S., Jurriaan J. Holzenspies, Fabian V. Roske, Wendy A. Bickmore & Joshua M. Brickman (2016). Polycomb enables primitive endoderm lineage priming in embryonic stem cells. eLife, 1-28, 5doi:10.7554/eLife.14926.

Arregi, Igor, Maria Climent, Dobromir Iliev, Jürgen Strasser, Nadège Gouignard, Jenny K. Johansson, Tania Singh, Magdalena Mazur, Henrik Semb, Isabella Artner, Liliana Minichiello & Edgar M. Pera (2016). Retinol dehydrogenase-10 regulates pancreas organogenesis and endocrine cell differentiation via paracrine retinoic acid signalling. Endocrinology, 1-17, doi:10.1210/en.2016-1745.

Comet, Itys, Eva M. Riising, Benjamin Leblanc & Kristian Helin (2016). Maintaining cell identity: PRC2-mediated regulation of transcription and cancer. Nat Reviews Cancer, 1-8, doi:10.1038/nrc.2016.83.

Højfeldt, Jonas W. & Kristian Helin (2016). Regional tumour glutamine supply affects chromatin and cell identity. Nature Cell Biology, 18(10), 1027-1029, doi:10.1038/ncb3414.

Grapin-Botton, Anne (2016). Three-dimensional pancreas organogenesis models. Diabetes Obes Metab, 18 (Suppl. 1), 33-40, doi:10.1111/dom.12720.

Martin Gonzalez, Javier, Sophie M Morgani, Robert A Bone, Kasper Bonderup, Sahar Abelchian, Cord Brakebusch & Joshua M Brickman (2016). Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency. Stem Cell Reports, 7(2), 177-191, doi:10.1016/j.stemcr.2016.07.009.

Radzisheuskaya, Aliaksandra, Daria Shlyueva, Iris Müller & Kristian Helin (2016). Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression. Nucleic Acids Research, 1-13,  doi: 10.1093/nar/gkw583.

Pedersen, Marianne Terndrup, Susanne Marije Kooistra, Aliaksandra Radzisheuskaya, Anne Laugesen, Jens Vilstrup Johansen, Daniel Geoffrey Hayward, Jakob Nilsson, Karl Agger & Kristian Helin (2016). Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development. The Embo Journal, 35(12), 1-15, doi:10.15252/embj.201593317.

Sch wämmle, Veit., Simone Sidoli, Chrystian Ruminowicz, Xudong Wu, Chung-Fan Lee, Kristian Helin & Ole N. Jensen (2016). Systems level analysis of histone H3 post-translational modifications reveals features of PTM crosstalk in chromatin regulation. Mol Cell Proteomics, 1-31, doi:10.1074/mcp.M115.054460.

Agger, Karl, Satoru Miyagi, Marianne T. Pedersen, Susanne M. Kooistra, Jens V. Johansen & Kristian Helin (2016). Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells. Genes & Development, 1-11, doi:10.1101/gad.280495.116.

Riso, Vincenzo, Marco Cammisa, Harpreet Kukreja, Zahra Anvar, Gaetano Verde, Angela Sparago, Basilia Acurzio, Shraddha Lad, Enza Lonardo, Aditya Sankar, Kristian Helin, Robert Feil, Annalisa Fico, Claudia Angelini, Giovanna Grimaldi & Andrea Riccio (2016). ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells. Nucleic Acids Research, 1-14, doi: 10.1093/nar/gkw505

Vishnubalaji, Radhakrishnan, Rimi Hamam, Shijun Yue, Omar Al-Obeed, Moustapha Kassem, Fei-Fei Liu, Abdullah Aldahmash & Nehad M. Alajez (2016). MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1. Oncotarget, 1-14, doi:10.18632/oncotarget.8937.

Bao, Jianqiang*, Kristoffer Vitting-Seerup, Johannes Waage, Chong Tang, Ying Ge, Bo T. Porse* & Wei Yan* (2016). UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genetics, 12(5), e1005863, doi:10.1371/journal.pgen.1005863.  *authors contributed equally

Pundhir, Sachin, Frederik. O. Bagger, Felicia. B. Lauridsen, Nicolas Rapin & Bo T. Porse (2016). Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality. Nucleic Acids Res, 1-15, doi: 10.1093/nar/gkw250. 

O'Connor, C., F. Lohan, J. Campos, E. Ohlsson, M. Salome, C. Forde, R. Artschwager, R. M. Liskamp, M. R. Cahill, P. A. Kiely, B. Porse & K. Keeshan (2016). The presence of C/EBPalpha and its degradation are both required for TRIB2-mediated leukaemia. Oncogene, 1-10, doi:10.1038/onc.2016.66.

Di Stefano, Bruno, Samuel Collombet, Janus Schou Jakobsen, Michael Wierer, Jose Luis Sardina, Andreas Lackner, Ralph Stadhouders, Carolina Segura-Morales, Mirko Francesconi, Francesco Limone, Matthias Mann, Bo Porse, Denis Thieffry & Thomas Graf (2016). C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4. Nature Cell Biology, 18(4), 371-381, doi:10.1038/ncb3326.

Helbo, Alexandra Søgaard, Marianne Treppendahl, Derya Aslan, Konstantinos Dimopoulos, Cecilie Nandrup-Bus, Mette Skov Holm, Mette Klarskov Andersen, Gangning Liang, Lasse Sommer Kristensen & Kirsten Grønbæk (2015). Hypermethylation of the VTRNA1-3 Promoter is Associated with Poor Outcome in Lower Risk Myelodysplastic Syndrome Patients. Genes (Basel), 6(4), 977-990, doi:10.3390/genes6040977.

Rasmussen, Kasper Dindler & Kristian Helin (2016). Role of TET enzymes in DNA methylation, development, and cancer. Genes & Development, 30(7), 733-750, doi:10.1101/gad.276568.115.

Dahl-Jensen, Svend, Manuel Figueiredo-Larsen, Anne Grapin-Botton & Kim Sneppen (2016). Short-range growth inhibitory signals from the epithelium can drive non-stereotypic branching in the pancreas. Physical Biology, 13(1):016007, doi: 10.1088/1478-3975/13/1/016007.

Scourzic, L., L. Couronne, M. T. Pedersen, V. Della Valle, M. Diop, E. Mylonas, J. Calvo, E. Mouly, C. K. Lopez, N. Martin, M. Fontenay, A. Bender, S. Guibert, P. Dubreuil, P. Dessen, N. Droin, F. Pflumio, M. Weber, P. Gaulard, K. Helin, T. Mercher & O. A. Bernard (2016). DNMT3AR882H mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice. Leukemia, doi:10.1038/leu.2016.29.

Rothová, Michaela, Jurriaan J. Hölzenspies, Alessandra Livigni, Santiago Nahuel Villegas & Joshua M. Brickman (2016). Differentiation of Mouse Embryonic Stem Cells into Ventral Foregut Precursors. Current Protocols in Stem Cell Biology, 36:1G.3.1-1G.3.12. doi: 10.1002/9780470151808.sc01g03s36

Aggerholm-Pedersen, Ninna, Christina Demuth, Akmal Safwat, Peter Meldgaard, Moustapha Kassem & Boe Sandahl Sorensen (2016). Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy. Stem Cells International, 20168, doi:10.1155/2016/9601493.

Grassilli, E., F. Pisano, A. Cialdella, S. Bonomo, C. Missaglia, M. G. Cerrito, L. Masiero, L. Ianzano, F. Giordano, V. Cicirelli, R. Narloch, F. D'Amato, B. Noli, G. L. Ferri, B. E. Leone, G. Stanta, S. Bonin, K. Helin, R. Giovannoni & M. Lavitrano (2016). A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation. Oncogene, doi:10.1038/onc.2015.504.

Harkness, Linda, Walid Zaher, Nicholas Ditzel, Adiba Isa & Moustapha Kassem (2016). CD146/MCAM defines functionality of human bone marrow stromal stem cell populations. Stem Cell Research & Therapy, 7(1), 4, doi:10.1186/s13287-015-0266-z.

2015

Galán-Díez, Marta, Adiba Isa, Marco Ponzetti, Morten Frost Nielsen, Moustapha Kassem & Stavroula Kousteni Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutations. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, doi:10.1016/j.bbamcr.2015.11.037.

Golonzhka, Olga, Alex Nord, Paul L F. Tang, Susan Lindtner, Athena R Ypsilanti, Elisabetta Ferretti, Axel Visel, Licia Selleri & John L R. Rubenstein (2015). Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron, 88(6), 1192-1207, doi:10.1016/j.neuron.2015.10.045.

Larsen, Simon A., Theresa Meldgaard, Agla J. Fridriksdottir, Simon Lykkemark, Pi C. Poulsen, Laura F. Overgaard, Helene B. Petersen, Ole William Petersen & Peter Kristensen (2016). Raising an Antibody Specific to Breast Cancer Subpopulations Using Phage Display on Tissue Sections. Cancer Genomics Proteomics, 13(1), 21-30.

Paul, Franziska, Ya’ara Arkin, Amir Giladi, Diego Adhemar Jaitin, Ephraim Kenigsberg, Hadas Keren-Shaul, Deborah Winter, David Lara-Astiaso, Meital Gury, Assaf Weiner, Eyal David, Nadav Cohen, Felicia Kathrine Bratt Lauridsen, Simon Haas, Andreas Schlitzer, Alexander Mildner, Florent Ginhoux, Steffen Jung, Andreas Trumpp, Bo Torben Porse, Amos Tanay & Ido Amit. Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. Cell, doi: 10.1016/j.cell.2015.11.013. (epub ahead of print: November 25, 2015).

Horn, Signe, Jeannette S. Kirkegaard, Soraya Hoelper, Philip A. Seymour, Claude Rescan, Jens H. Nielsen, Ole D. Madsen, Jan N. Jensen, Marcus Krüger, Mads Grønborg & Jonas Ahnfelt-Rønne Research resource: A dual proteomic approach identifies regulated islet proteins during beta cell mass expansion in vivo. Molecular Endocrinology, me.2015-1208, doi: 10.1210/me.2015-1208.

Koltowska, Katarzyna, Anne Karine Lagendijk, Cathy Pichol-Thievend, Johanna C Fischer, Mathias Francois, Elke A Ober, Alpha S Yap & Benjamin M Hogan (2015). Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. Cell Reports, 13(9), 1828-1841, doi:10.1016/j.celrep.2015.10.055.

Ohlsson, E., M. B. Schuster, M. Hasemann & B. T. Porse (2015). The multifaceted functions of C/EBP[alpha] in normal and malignant hematopoiesis. Leukemia, doi:10.1038/leu.2015.324.

Cruickshank, V. Adam, Patrycja Sroczynska, Aditya Sankar, Satoru Miyagi, Carsten Friis Rundsten, Jens Vilstrup Johansen & Kristian Helin (2015). SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance. Plos One, 10(11), e0142806, doi:10.1371/journal.pone.0142806.

Berclaz, Corinne, Anja Schmidt-Christensen, Daniel Szlag, Jerome Extermann, Lisbeth Hansen, Arno Bouwens, Martin Villiger, Joan Goulley, Frans Schuit, Anne Grapin-Botton, Theo Lasser & Dan Holmberg (2015). Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging. Diabetologia, 1-10, doi:10.1007/s00125-015-3819-x.

Fridriksdottir, Agla J., Jiyoung Kim, Rene Villadsen, Marie Christine Klitgaard, Branden M. Hopkinson, Ole William Petersen & Lone Ronnov-Jessen (2015). Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture. Nature Communications, 6, doi:10.1038/ncomms9786.

Bagger, Frederik Otzen, Damir Sasivarevic, Sina Hadi Sohi, Linea Gøricke Laursen, Sachin Pundhir, Casper Kaae Sønderby, Ole Winther, Nicolas Rapin & Bo T. Porse (2015). BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis. Nucleic Acids Research, doi:10.1093/nar/gkv1101.

Vandamme, Julien, Simone Sidoli, Luca Mariani, Carsten Friis, Jesper Christensen, Kristian Helin, Ole N. Jensen & Anna Elisabetta Salcini (2015). H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans. Nucleic Acids Res, doi:10.1093/nar/gkv1063.

Wu, Xudong, Ida Holst Bekker-Jensen, Jesper Christensen, Kasper D. Rasmussen, Simone Sidoli, Yan Qi, Yu Kong, Xi Wang, Yajuan Cui, Zhijian Xiao, Guogang Xu, Kristine Williams, Juri Rappsilber, Casper K. Sonderby, Ole Winther, Ole N. Jensen & Kristian Helin (2015). Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals. Cell Res, doi:10.1038/cr.2015.121.

Andersen, Rikke K., Walid Zaher, Kenneth H. Larsen, Nicholas Ditzel, Katharina Drews, Wasco Wruck, James Adjaye, Basem M. Abdallah & Moustapha Kassem (2015). Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells. Stem Cell Res Ther, 6196, doi:10.1186/s13287-015-0188-9.

Shih, Hung Ping, Philip A. Seymour, Nisha A. Patel, Ruiyu Xie, Allen Wang, Patrick P. Liu, Gene W. Yeo, Mark A. Magnuson & Maike Sander (2015). A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. Cell Reports, doi: 10.1016/j.celrep.2015.08.082.

Knudsen, Kasper Jermiin, Matilda Rehn, Marie Sigurd Hasemann, Nicolas Rapin, Frederik Otzen Bagger, Ewa Ohlsson, Anton Willer, Anne-Katrine Frank, Elisabeth Søndergaard, Johan Jendholm, Lina Thorén, Julie Lee, Justyna Rak, Kim Theilgaard-Mönch & Bo Torben Porse (2015). ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation. Genes & Development, 29(18), 1915-1929, doi:10.1101/gad.268409.115.

Morgani, Sophie M. & Josh M. Brickman (2015). LIF supports primitive endoderm expansion during pre-implantation development. Development, doi:10.1242/dev.125021.

Tawana, Kiran, Jun Wang, Aline Renneville, Csaba Bödör, Robert Hills, Chey Loveday, Aleksandar Savic, Frederik W. Van Delft, Jennifer Treleaven, Panayiotis Georgiades, Elizabeth Uglow, Norio Asou, Naokuni Uike, Maruša Debeljak, Janez Jazbec, Philip Ancliff, Rosemary Gale, Xavier Thomas, Valerie Mialou, Konstanze Döhner, Lars Bullinger, Beatrice Mueller, Thomas Pabst, Matthias Stelljes, Brigitte Schlegelberger, Eva Wozniak, Sameena Iqbal, Jessica Okosun, Shamzah Araf, Anne-Katrine Frank, Felicia B. Lauridsen, Bo Porse, Claus Nerlov, Carolyn Owen, Inderjeet Dokal, John Gribben, Matthew Smith, Claude Preudhomme, Claude Chelala, Jamie Cavenagh & Jude Fitzgibbon (2015). Disease evolution and outcomes in familial AML with germline CEBPA mutations. Blood, 126(10), 1214-1223, doi:10.1182/blood-2015-05-647172.

Al-Toub, Mashael, Radhakrishnan Vishnubalaji, Rimi Hamam, Moustapha Kassem, Abdullah Aldahmash & Nehad M. Alajez (2015). CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells. Stem Cell Res Ther, 6(1), 135, doi:10.1186/s13287-015-0123-0.

Chen, Li, Kaikai Shi, Charles E. Frary, Nicholas Ditzel, Huimin Hu, Weimin Qiu & Moustapha Kassem (2015). Inhibiting actin depolymerization enhances osteoblast differentiation and bone formation in human stromal stem cells. Stem Cell Res, 15(2), 281-289, doi:10.1016/j.scr.2015.06.009.

Martin, David, Yung Hae Kim, Dror Sever, Chai-An Mao, Jacques-Antoine Haefliger & Anne Grapin-Botton (2015). REST represses a subset of the pancreatic endocrine differentiation program. Developmental Biology, doi:10.1016/j.ydbio.2015.07.002. (epub ahead of print).

Rumman, Mohammad, Jyotsno Dhawan & Moustapha Kassem (2015). Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration. Stem Cells, doi:10.1002/stem.2056.

Ptaschinski, Catherine, Sumanta Mukherjee, Martin L. Moore, Mareike Albert, Kristian Helin, Steven L. Kunkel & Nicholas W. Lukacs (2015). RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo. PLoS Pathog, 11(6), e1004978, doi:10.1371/journal.ppat.1004978.

Hölzenspies, Jurriaan, Gelo Dela Cruz & Brickman Joshua M. (2015). Resolving Heterogeneity: Fluorescence-Activated Cell Sorting of Dynamic Cell Populations from Feeder-Free Mouse Embryonic Stem Cell Culture. Methods Mol Biol, doi:10.1007/7651_2015_254.

Fork, Christian, Lunda Gu, Juliane Hitzel, Ivana Josipovic, Jiong Hu, Michael SzeKa Wong, Yuliya Ponomareva, Mareike Albert, Sandra U. Schmitz, Shizuka Uchida, Ingrid Fleming, Kristian Helin, Dieter Steinhilber, Matthias S. Leisegang & Ralf P. Brandes (2015). Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5. Arteriosclerosis Thrombosis and Vascular Biology, doi:10.1161/atvbaha.115.305561.

Ueda, Takeshi, Akiko Nagamachi, Keiyo Takubo, Norimasa Yamasaki, Hirotaka Matsui, Akinori Kanai, Yuichiro Nakata, Kenichiro Ikeda, Takaaki Konuma, Hideaki Oda, Linda Wolff, Zen-ichiro Honda, Xudong Wu, Kristian Helin, Atsushi Iwama, Toshio Suda, Toshiya Inaba & Hiroaki Honda (2015). Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood, 125(22), 3437-3446, doi:10.1182/blood-2014-03-562694.

Ober, Elke A. & Anne Grapin-Botton (2015). At new heights - endodermal lineages in development and disease. Development, 142(11), 1912-1917, doi:10.1242/dev.121095.

Stasiulewicz, Magdalena, Shona Gray, Ioanna Mastromina, Joana Clara Silva, Mia Bjorklund, Philip A. Seymour, David Booth, Calum Thompson, Rich Green, Emma A. Hall, Palle Serup & J. Kim Dale (2015). A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened. Development, doi:10.1242/dev.125237 (epub ahead of print on May 20, 2015).

Berclaz, Corinne, Christophe Pache, Arno Bouwens, Daniel Szlag, Antonio Lopez, Lieke Joosten, Selen Ekim, Maarten Brom, Martin Gotthardt, Anne Grapin-Botton & Theo Lasser (2015). Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers. Sci Rep, 510385, doi:10.1038/srep10385.

Rasmussen, Kasper Dindler & Kristian Helin (2015). TET1: an epigenetic guardian of lymphomagenesis. Nature Immunology, 16(6), 592-594, doi:10.1038/ni.3176.

Larsen, Simon Asbjørn, Theresa Meldgaard, Agla J. Fridriksdottir, Simon Lykkemark, Pi Camilla Poulsen, Laura F. Overgaard, Helene Bundgaard Petersen, Ole William Petersen & Peter Kristensen (2015). Selection of a breast cancer subpopulation-specific antibody using phage display on tissue sections. Immunologic Research, doi:10.1007/s12026-015-8657-x. (epub ahead of print).

Abdallah, Basem M., Nicholas Ditzel, Jorge Laborda, Gerard Karsenty & Moustapha Kassem (2015) DLK1 regulates whole body glucose metabolism: A negative feedback regulation of the osteocalcin-insulin loop. Diabetes, doi: 10.2337/db14-1642. (Epub ahead of print).

Funa, Nina S.*, Karen A. Schachter*, Mads Lerdrup, Jenny Ekberg, Katja Hess, Nikolaj Dietrich, Christian Honoré, Klaus Hansen & Henrik Semb (2015). β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4. Cell Stem Cell, doi:10.1016/j.stem.2015.03.008 (epub ahead of print on April 23, 2015). *authors contributed equally

Rasmussen, Kasper D., Guangshuai Jia, Jens V. Johansen, Marianne T. Pedersen, Nicolas Rapin, Frederik O. Bagger, Bo T. Porse, Olivier A. Bernard, Jesper Christensen & Kristian Helin (2015). Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis. Genes and Development, 29(9):910-22, doi:10.1101/gad.260174.115.

Jafari, Abbas, Majken S. Siersbaek, Li Chen, Diyako Qanie, Walid Zaher, Basem M. Abdallah & Moustapha Kassem (2015). Pharmacological Inhibition of PRKG1 Enhances Bone Formation by Human Skeletal Stem Cells through Activation of RhoA-Akt Signaling. Stem Cells, doi:10.1002/stem.2013.

Kim, Yung Hae, Hjalte List Larsen, Paul Rue, Laurence A. Lemaire, Jorge Ferrer & Anne Grapin-Botton (2015). Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas. PLoS Biology, 13(3), e1002111, doi:10.1371/journal.pbio.1002111.

Mora-Jensen H, Jendholm J, Rapin N, Klarskov Andersen M, Roug AS, Otzen Bagger F, Bullinger L, Winther O, Borregaard N, Porse BT, Theilgaard-Mönch K. (2015) Cellular origin of prognostic chromosomal aberrations in AML patients. Leukemia, doi: 10.1038/leu.2015.30. 

Grapin-Botton, Anne, Philip Allan Seymour, Gérard Gradwohl (2015). Pairing-up SOX to kick-start beta cell genesis. Diabetologia, doi:10.1007/s00125-015-3539-2. (epub ahead of print March 4, 2015).

Jakobsen, Janus, Frederik Bagger, Marie S. Hasemann, Mikkel B. Schuster, Anne-Katrine Frank, Johannes Waage, Kristoffer Vitting-Seerup & Bo T. Porse (2015). Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq. BMC Genomics, 16, 46, doi:10.1186/s12864-014-1195-4.

Lemaire, Laurence A., Joan Goulley, Yung Hae Kim, Solenne Carat, Patrick Jacquemin, Jacques Rougemont, Daniel B. Constam & Anne Grapin-Botton (2015). Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis. Development, 142(5), 858-870, doi: 10.1242/dev.114611.

Abdallah, Basem M., Abbas Jafari, Walid Zaher, Weimin Qiu & Moustapha Kassem (2015). Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation. Bone, 70, 28-36, doi: 10.1016/j.bone.2014.07.028.

Bao, Jianqiang, Chong Tang, Shuiqiao Yuan, Bo T. Porse & Wei Yan (2015). UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome. Development, 142(2), 352-362, doi: 10.1242/dev.115642. (epub ahead of print  December 11, 2014)

Greggio, Chiara, Filippo De Franceschi & Anne Grapin-Botton (2015). Concise Reviews: In Vitro-Produced Pancreas Organogenesis Models in Three Dimensions: Self-Organization From Few Stem Cells or Progenitors. Stem Cells, 33(1), 8-14, doi:10.1002/stem.1828. (epub ahead of print December 18, 2014)

Kassem, Moustapha & Paolo Bianco (2015). Skeletal stem cells in space and time. Cell, 160(1-2), 17-19, doi: 10.1016/j.cell.2014.12.034.

Laing, Adam F., Sally Lowell & Joshua M. Brickman (2015). Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression. Developmental Biology, 397(1), 56-66, doi: 10.1016/j.ydbio.2014.10.007. (epub ahead of print October 23, 2014)

Vishnubalaji, R., R. Hamam, M. H. Abdulla, M. A. Mohammed, M. Kassem, O. Al-Obeed, A. Aldahmash & N. M. Alajez (2015). Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer. Cell Death Disease, 6, e1614, doi: 10.1038/cddis.2014.556.

Xu, Ming-Jiang, Dechun Feng, Hailong Wu, Hua Wang, Yvonne Chan, Jay Kolls, Niels Borregaard, Bo T. Porse, Thorsten Berger, Tak W. Mak, Jack B. Cowland, Xiaoni Kong & Bin Gao (2015). Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: A critical role for IL-6/STAT3. Hepatology, 61(2), 692-702, doi:10.1002/hep.27447.

2014Til toppen

Andersson, Robin, Claudia Gebhard, Irene Miguel-Escalada, Ilka Hoof, Jette Bornholdt, Mette Boyd, Yun Chen, Xiaobei Zhao, Christian Schmidl, Takahiro Suzuki, Evgenia Ntini, Erik Arner, Eivind Valen, Kang Li, Lucia Schwarzfischer, Dagmar Glatz, Johanna Raithel, Berit Lilje, Nicolas Rapin, Frederik Otzen Bagger, Mette Jørgensen, Peter Refsing Andersen, Nicolas Bertin, Owen Rackham, A. Maxwell Burroughs, J. Kenneth Baillie, Yuri Ishizu, Yuri Shimizu, Erina Furuhata, Shiori Maeda, Yutaka Negishi, Christopher J. Mungall, Terrence F. Meehan, Timo Lassmann, Masayoshi Itoh, Hideya Kawaji, Naoto Kondo, Jun Kawai, Andreas Lennartsson, Carsten O. Daub, Peter Heutink, David A. Hume, Torben Heick Jensen, Harukazu Suzuki, Yoshihide Hayashizaki, Ferenc Mueller, Alistair R. R. Forrest, Piero Carninci, Michael Rehli, Albin Sandelin & Fantom Consortium (2014). An atlas of active enhancers across human cell types and tissues. Nature, 507(7493), 455-461, doi:10.1038/nature12787.

Balk-Møller, Emilie, Jiyoung Kim, Branden Hopkinson, Vera Timmermans-Wielenga, Ole W. Petersen & Rene Villadsen (2014). A Marker of Endocrine Receptor-Positive Cells, CEACAM6, Is Shared by Two Major Classes of Breast Cancer Luminal and HER2-Enriched. American Journal of Pathology, 184(4), 1198-1208, doi:10.1016/j.ajpath.2013.12.013.           

Chen, Li, Kim Holmstrøm, Weimin Qiu, Nicholas Ditzel, Kaikai Shi, Lea Hokland & Moustapha Kassem (2014). MicroRNA-34a Inhibits Osteoblast Differentiation and In Vivo Bone Formation of Human Stromal Stem Cells. Stem Cells, 32(4), 902-912, doi:10.1002/stem.1615.

Comet, Itys & Kristian Helin (2014). Revolution in the Polycomb hierarchy. Nature Structural & Molecular Biology, 21(7), 573-575, doi: 10.1038/nsmb.2848.

da Rocha, Simao Teixeira, Valentina Boeva, Martin Escamilla-Del-Arenal, Katia Ancelin, Camille Granier, Neuza Reis Matias, Serena Sanulli, Jen Chow, Edda Schulz, Christel Picard, Syuzo Kaneko, Kristian Helin, Danny Reinberg, A. Francis Stewart, Anton Wutz, Raphael Margueron & Edith Heard (2014). Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome. Molecular Cell, 53(2), 301-316, doi:10.1016/j.molcel.2014.01.002.

Dawson, Jonathan I., Janos Kanczler, Rahul Tare, Moustapha Kassem & Richard O. C. Oreffo (2014). Concise Review: Bridging the Gap: Bone Regeneration Using Skeletal Stem Cell-Based Strategies-Where Are We Now? Stem Cells, 32(1), 35-44, doi:10.1002/stem.1559.

De Raedt, Thomas, Eline Beert, Eric Pasmant, Armelle Luscan, Hilde Brems, Nicolas Ortonne, Kristian Helin, Jason L. Hornick, Victor Mautner, Hildegard Kehrer-Sawatzki, Wade Clapp, James Bradner, Michel Vidaud, Meena Upadhyaya, Eric Legius & Karen Cichowski (2014). PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature, 514(7521), 247-251, doi:10.1038/nature13561.

Dunworth, William P., Jose Cardona-Costa, Esra Cagavi Bozkulak, Jun-Dae Kim, Stryder Meadows, Johanna C. Fischer, Yeqi Wang, Ondine Cleaver, Yibing Qyang, Elke A. Ober & Suk-Won Jin (2014). Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos. Circulation Research, 114(1), 56-66, doi:10.1161/circresaha.114.302452.

Frankenberg, Stephen R., Dale Frank, Richard Harland, Andrew D. Johnson, Jennifer Nichols, Hitoshi Niwa, Hans R. Schoeler, Elly Tanaka, Chris Wylie & Joshua M. Brickman (2014). The POU-er of gene nomenclature. Development, 141(15), 2921-2923, doi:10.1242/dev.108407.

Ge, Ying & Bo T. Porse (2014). The functional consequences of intron retention: Alternative splicing coupled to NMD as a regulator of gene expression. Bioessays, 36(3), 236-243, doi:10.1002/bies.201300156.

Gingold, Hila, Disa Tehler, Nanna R. Christoffersen, Morten M. Nielsen, Fazila Asmar, Susanne M. Kooistra, Nicolaj S. Christophersen, Lise Lotte Christensen, Michael Borre, Karina D. Sørensen, Lars D. Andersen, Claus L. Andersen, Esther Hulleman, Tom Wurdinger, Elisabeth Ralfkiær, Kristian Helin, Kirsten Grønbæk, Torben Omtoft, Sebastian M. Waszak, Orna Dahan, Jakob Skou Pedersen, Anders H. Lund & Yitzhak Pilpel (2014). A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation. Cell, 158(6), 1281-1292, doi:10.1016/j.cell.2014.08.011.

Greggio, Chiara, Filippo De Franceschi, Manuel Figueiredo-Larsen & Anne Grapin-Botton (2014). In vitro pancreas organogenesis from dispersed mouse embryonic progenitors. [; Research Support, Non-U.S. Gov't; Video-Audio Media]. Journal of visualized experiments : JoVE(89), e51725, doi:10.3791/51725.

Hamilton, William B. & Joshua M. Brickman (2014). Erk Signaling Suppresses Embryonic Stem Cell Self-Renewal to Specify Endoderm. Cell Reports, 9(6), 2056-2070, doi:10.1016/j.celrep.2014.11.032.

Hanotel, Julie, Nathalie Bessodes, Aurore Thelie, Marie Hedderich, Karine Parain, Benoit Van Driessche, Karina De Oliveira Brandao, Sadia Kricha, Mette C. Jørgensen, Anne Grapin-Botton, Palle Serup, Carine Van Lint, Muriel Perron, Tomas Pieler, Kristine A. Henningfeld & Eric J. Bellefroid (2014). The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbpj downstream target that suppresses glutamatergic and promotes GABAergic neuronal fate in the dorsal neural tube. Developmental Biology, 386(2), 340-357, doi:10.1016/j.ydbio.2013.12.024.

Hasemann, Marie S., Felicia K. B. Lauridsen, Johannes Waage, Janus S. Jakobsen, Anne-Katrine Frank, Mikkel B. Schuster, Nicolas Rapin, Frederik O. Bagger, Philipp S. Hoppe, Timm Schroeder & Bo T. Porse (2014). C/EBP alpha Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors. Plos Genetics, 10(1), e1004079, doi:10.1371/journal.pgen.1004079.

Heinemann, Bo, Jesper Morten Nielsen, Heidi Rye Hudlebusch, Michael J. Lees, Dorthe Vang Larsen, Thomas Boesen, Marc Labelle, Lars-Ole Gerlach, Peter Birk & Kristian Helin (2014). Inhibition of demethylases by GSK-J1/J4. Nature, 514(7520), E1-E2, doi:10.1038/nature13688.

Kesavan, Gokul, Oliver Lieven, Anant Mamidi, Zarah Löf Öhlin, Jenny Kristina Johansson, Wan-Chun Li, Silvia Lommel, Thomas Uwe Greiner & Henrik Semb (2014). Cdc42/N-WASP signaling links actin dynamics to pancreatic beta cell delamination and differentiation. Development, 141(3), 685-696, doi:10.1242/dev.100297.
Link to Press Release: Leaving home: Beta cells' way to maturity

Klein, Hans-Ulrich, Martin Schaefer, Bo T. Porse, Marie S. Hasemann, Katja Ickstadt & Martin Dugas (2014). Integrative analysis of histone ChIP-seq and transcription data using Bayesian mixture models. Bioinformatics, 30(8), 1154-1162, doi:10.1093/bioinformatics/btu003.

Kooistra, Susanne Marije, Lise Christine Rudkjaer Nørgaard, Michael James Lees, Cornelia Steinhauer, Jens Vilstrup Johansen & Kristian Helin (2014). A Screen Identifies the Oncogenic Micro-RNA miR-378a-5p as a Negative Regulator of Oncogene-Induced Senescence. Plos One, 9(3), e91034, doi:10.1371/journal.pone.0091034.

Langlois, Thierry, Barbara da Costa Reis Monte-Mor, Gaelle Lenglet, Nathalie Droin, Caroline Marty, Jean-Pierre Le Couedic, Carole Almire, Nathalie Auger, Thomas Mercher, Francois Delhommeau, Jesper Christensen, Kristian Helin, Najet Debili, Francois Fuks, Olivier A. Bernard, Eric Solary, William Vainchenker & Isabelle Plo (2014). TET2 Deficiency Inhibits Mesoderm and Hematopoietic Differentiation in Human Embryonic Stem Cells. Stem Cells, 32(8), 2084-2097, doi:10.1002/stem.1718.

Laugesen, Anne & Kristian Helin (2014). Chromatin Repressive Complexes in Stem Cells, Development, and Cancer. Cell Stem Cell, 14(6), 735-751, doi:10.1016/j.stem.2014.05.006.

Li, Hongzhe, Roshanak Ghazanfari, Dimitra Zacharaki, Nicholas Ditzel, Joan Isern, Marja Ekblom, Simon Mendez-Ferrer, Moustapha Kassem & Stefan Scheding (2014). Low/Negative Expression of PDGFR-alpha Identifies the Candidate Primary Mesenchymal Stromal Cells in Adult Human Bone Marrow. Stem Cell Reports, 3(6), 965-974, doi:10.1016/j.stemcr.2014.09.018.

Liu, Yawei, Robert Carlsson, Manuel Comabella, JunYang Wang, Michael Kosicki, Belinda Carrion, Maruf Hasan, Xudong Wu, Xavier Montalban, Morten Hanefeld Dziegiel, Finn Sellebjerg, Per Soelberg Sørensen, Kristian Helin & Shohreh Issazadeh-Navikas (2014). FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS. Nature Medicine, 20(3), 272-282, doi:10.1038/nm.3485.

Lieven, Oliver, Julia Dronka, Stephan Burmuhl & Ulrich Rüther (2014). Differential Binding of Lef1 and Msx1/2 Transcription Factors to Dkk1 CNEs Correlates with Reporter Gene Expression In Vivo. Plos One 9, 23, e115442, doi:10.1371/journal.pone.0115442.

Markmiller, Sebastian, Nicole Cloonan, Rea M. Lardelli, Karen Doggett, Maria-Cristina Keightley, Yeliz Boglev, Andrew J. Trotter, Annie Y. Ng, Simon J. Wilkins, Heather Verkade, Elke A. Ober, Holly A. Field, Sean M. Grimmond, Graham J. Lieschke, Didier Y. R. Stainier & Joan K. Heath (2014). Minor class splicing shapes the zebrafish transcriptome during development. Proceedings of the National Academy of Sciences of the United States of America, 111(8), 3062-3067, doi:10.1073/pnas.1305536111.

Martin, Javier, Sophie Morgani, Kasper Bonderup, Sahar Abelechian, Cord Brakebusch & Joshua Brickman (2014). 100 % Coat-coloured chimaera generation by single es cell injection. Transgenic Research, 23(5), 848-848 (Meeting Abstract).

Morgani, Sophie M. & Joshua M. Brickman (2014). The molecular underpinnings of totipotency. Philosophical Transactions of the Royal Society B-Biological Sciences, 369(1657), doi:10.1098/rstb.2013.0549.

Norrie, Ida Christine, Ewa Ohlsson, Olaf Nielsen, Marie Sigurd Hasemann & Bo T. Porse (2014). C/EBP alpha Is Dispensable for the Ontogeny of PD-1+CD4+Memory T Cells but Restricts Their Expansion in an Age-Dependent Manner. Plos One, 9(1), e84728, doi:10.1371/journal.pone.0084728.

Ohlsson, Ewa, Marie Sigurd Hasemann, Anton Willer, Felicia Kathrine Bratt Lauridsen, Nicolas Rapin, Johan Jendholm & Bo Torben Porse (2014). Initiation of MLL-rearranged AML is dependent on C/EBP alpha. Journal of Experimental Medicine, 211(1), 5-13, doi:10.1084/jem.20130932.

Piunti, Andrea, Alessandra Rossi, Aurora Cerutti, Mareike Albert, Sriganesh Jammula, Andrea Scelfo, Laura Cedrone, Giulia Fragola, Linda Olsson, Haruhiko Koseki, Giuseppe Testa, Stefano Casola, Kristian Helin, Fabrizio d'Adda di Fagagna & Diego Pasini (2014). Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication. Nature Communications, 5, doi:10.1038/ncomms4649.

Qiu, Weimin & Moustapha Kassem (2014). miR-141-3p inhibits human stromal (mesenchymal) stem cell proliferation and differentiation. Biochimica Et Biophysica Acta-Molecular Cell Research, 1843(9), 2114-2121, doi:10.1016/j.bbamcr.2014.06.004.

Rapin, Nicolas & Bo T. Porse (2014). Oncogenic fusion proteins expressed in immature hematopoietic cells fail to recapitulate the transcriptional changes observed in human AML. Oncogenesis, 3, e106-e106, doi:10.1038/oncsis.2014.22.

Rapin, Nicolas, Frederik Otzen Bagger, Johan Jendholm, Helena Mora-Jensen, Anders Krogh, Alexander Kohlmann, Christian Thiede, Niels Borregaard, Lars Bullinger, Ole Winther, Kim Theilgaard-Mönch & Bo T. Porse (2014). Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients. Blood, 123(6), 894-904, doi:10.1182/blood-2013-02-485771.

Riising, Eva Madi, Itys Comet, Benjamin Leblanc, Xudong Wu, Jens Vilstrup Johansen & Kristian Helin (2014). Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide. Molecular Cell, 55(3), 347-360, doi:10.1016/j.molcel.2014.06.005.

Rishi, Loveena, Maura Hannon, Mara Salome, Marie Hasemann, Anne-Katrine Frank, Joana Campos, Jennifer Timoney, Caitriona O'Connor, Mary R. Cahill, Bo Porse & Karen Keeshan (2014). Regulation of Trib2 by an E2F1-C/EBP alpha feedback loop in AML cell proliferation. Blood, 123(15), 2389-2400, doi:10.1182/blood-2013-07-511683.

Rué, Paul, Kim, Yung Hae, List Larsen, Hjalte, Grapin-Botton, Anne, Martinez Arias, Alfonso (2014). A framework for the analysis of symmetric and asymmetric divisions in developmental processes. BIORXIV/2014/010835, doi: 10.1101/010835.

Seymour, Philip A. (2014). Sox9: a master regulator of the pancreatic program. The review of diabetic studies : RDS, 11(1), 51-83, doi:10.1900/rds.2014.11.51.

Sroczynska, Patrycja, V. Adam Cruickshank, John-Paul Bukowski, Satoru Miyagi, Frederik Otzen Bagger, Julian Walfridsson, Mikkel Bruhn Schuster, Bo Porse & Kristian Helin (2014). shRNA screening identifies JMJD1C as being required for leukemia maintenance. Blood, 123(12), 1870-1882, doi:10.1182/blood-2013-08-522094.

Terndrup, Marianne, Karl Agger, Anne Laugesen, Jens V. Johansen, Paul A. C. Cloos, Jesper Christensen & Kristian Helin (2014). The Demethylase JMJD2C Localizes to H3K4me3-Positive Transcription Start Sites and Is Dispensable for Embryonic Development. Molecular and Cellular Biology, 34(6), 1031-1045, doi:10.1128/mcb.00864-13.

Twine, Natalie A., Li Chen, Chi N. Pang, Marc R. Wilkins & Moustapha Kassem (2014). Identification of differentiation-stage specific markers that define the ex vivo osteoblastic phenotype. Bone, 67, 23-32, doi:10.1016/j.bone.2014.06.027.

van Impel, Andreas, Zhonghua Zhao, Dorien M. A. Hermkens, M. Guy Roukens, Johanna C. Fischer, Josi Peterson-Maduro, Henricus Duckers, Elke A. Ober, Philip W. Ingham & Stefan Schulte-Merker (2014). Divergence of zebrafish and mouse lymphatic cell fate specification pathways. Development, 141(6), 1228-U1101, doi:10.1242/dev.105031.

Vitting-Seerup, Kristoffer, Bo Torben Porse, Albin Sandelin & Johannes Waage (2014). spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data. BMC Bioinformatics, 15, doi:10.1186/1471-2105-15-81.

Willer, A., J. S. Jakobsen, E. Ohlsson, N. Rapin, J. Waage, M. Billing, L. Bullinger, S. Karlsson & Bo T. Porse (2014). TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia. Leukemia, doi: 10.1038/leu.2014.307.

Willet, Spencer G., Michael A. Hale, Anne Grapin-Botton, Mark A. Magnuson, Raymond J. MacDonald & Christopher V. E. Wright (2014). Dominant and context-specific control of endodermal organ allocation by Ptf1a. Development, 141(22), 4385-4394, doi:10.1242/dev.114165.

Williams, Kristine, Jesper Christensen, Juri Rappsilber, Anders Laerke Nielsen, Jens Vilstrup Johansen & Kristian Helin (2014). The Histone Lysine Demethylase JMJD3/KDM6B Is Recruited to p53 Bound Promoters and Enhancer Elements in a p53 Dependent Manner. Plos One, 9(5), e96545, doi:10.1371/journal.pone.0096545.

Wong, Yan-Fung, Chris N. Micklem, Masataka Taguchi, Hidehiro Itonaga, Yasushi Sawayama, Daisuke Imanishi, Shinichi Nishikawa, Yasushi Miyazaki & Lars Martin Jakt (2014). Longitudinal Analysis of DNA Methylation in CD34+Hematopoietic Progenitors in Myelodysplastic Syndrome. Stem Cells Translational Medicine, 3(10), 1188-1198, doi:10.5966/sctm.2014-0035.

Zaher, Walid, Linda Harkness, Abbas Jafari & Moustapha Kassem (2014). An update of human mesenchymal stem cell biology and their clinical uses. Archives of Toxicology, 88(5), 1069-1082, doi:10.1007/s00204-014-1232-8.

2013 Til toppen

Albert, Mareike, Sandra U. Schmitz, Susanne M. Kooistra, Martina Malatesta, Cristina Morales Torres, Jens C. Rekling, Jens V. Johansen, Iratxe Abarrategui & Kristian Helin (2013). The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3. Plos Genetics, 9(4), e1003461, doi:10.1371/journal.pgen.1003461.

Arteaga, Maria Francisca, Jan-Henrik Mikesch, Jihui Qiu, Jesper Christensen, Kristian Helin, Scott C. Kogan, Shuo Dong & Chi Wai Eric So (2013). The Histone Demethylase PHF8 Governs Retinoic Acid Response in Acute Promyelocytic Leukemia. Cancer Cell, 23(3), 376-389, doi:10.1016/j.ccr.2013.02.014.

Asmar, Fazila, Vasu Punj, Jesper Christensen, Marianne T. Pedersen, Anja Pedersen, Anders B. Nielsen, Christoffer Hother, Ulrik Ralfkiær, Peter Brown, Elisabeth Ralfkiær, Kristian Helin & Kirsten Grenbæk (2013). Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Haematologica, 98(12), 1912-1920, doi:10.3324/haematol.2013.088740.

Bagger, Frederik Otzen, Nicolas Rapin, Kim Theilgaard-Mönch, Bogumil Kaczkowski, Lina A. Thoren, Johan Jendholm, Ole Winther & Bo T. Porse (2013). HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis. Nucleic Acids Research, 41(D1), D1034-D1039, doi:10.1093/nar/gks1021.

Ballabeni, Andrea, Raffaella Zamponi, Jodene K. Moore, Kristian Helin & Marc W. Kirschner (2013). Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proceedings of the National Academy of Sciences of the United States of America, 110(30), E2848-E2853, doi:10.1073/pnas.1310677110.

Bender, Sebastian, Yujie Tang, Anders M. Lindroth, Volker Hovestadt, David T. W. Jones, Marcel Kool, Marc Zapatka, Paul A. Northcott, Dominik Sturm, Wei Wang, Bernhard Radlwimmer, Jonas W. Hojfeldt, Nathalene Truffaux, David Castel, Simone Schubert, Marina Ryzhova, Huriye Seker-Cin, Jan Gronych, Pascal David Johann, Sebastian Stark, Jochen Meyer, Till Milde, Martin Schuhmann, Martin Ebinger, Camelia-Maria Monoranu, Anitha Ponnuswami, Spenser Chen, Chris Jones, Olaf Witt, V. Peter Collins, Andreas von Deimling, Nada Jabado, Stephanie Puget, Jacques Grill, Kristian Helin, Andrey Korshunov, Peter Lichter, Michelle Monje, Christoph Plass, Yoon-Jae Cho & Stefan M. Pfister (2013). Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas. Cancer Cell, 24(5), 660-672, doi:10.1016/j.ccr.2013.10.006.

Colak, Dilek, Sheng-Jian Ji, Bo T. Porse & Samie R. Jaffrey (2013). Regulation of Axon Guidance by Compartmentalized Nonsense-Mediated mRNA Decay. Cell, 153(6), 1252-1265, doi:10.1016/j.cell.2013.04.056.

de la Rica, Lorenzo, Javier Rodriguez-Ubreva, Mireia Garcia, Abdul Bmmk Islam, José M. Urquiza, Henar Hernando, Jesper Christensen, Kristian Helin, Carmen Gomez-Vaquero & Esteban Ballestar (2013). PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation. Genome Biology, 14(9), doi:10.1186/gb-2013-14-9-r99.

Di Croce, Luciano & Kristian Helin (2013). Transcriptional regulation by Polycomb group proteins. Nature Structural & Molecular Biology, 20(10), 1147-1155, doi:10.1038/nsmb.2669.

Egan, Chris M., Ulrika Nyman, Julie Skotte, Gundula Streubel, Siobhan Turner, David J. O'Connell, Vilma Rraklli, Michael J. Dolan, Naomi Chadderton, Klaus Hansen, Gwyneth Jane Farrar, Kristian Helin, Johan Holmberg & Adrian P. Bracken (2013). CHD5 Is Required for Neurogenesis and Has a Dual Role in Facilitating Gene Expression and Polycomb Gene Repression. Developmental Cell, 26(3), 223-236, doi:10.1016/j.devcel.2013.07.008.

Grassilli, Emanuela, Robert Narloch, Elena Federzoni, Leonarda Ianzano, Fabio Pisano, Roberto Giovannoni, Gabriele Romano, Laura Masiero, Biagio Eugenio Leone, Serena Bonin, Marisa Donada, Giorgio Stanta, Kristian Helin & Marialuisa Lavitrano (2013). Inhibition of GSK3B Bypass Drug Resistance of p53-Null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy. Clinical Cancer Research, 19(14), 3820-3831, doi:10.1158/1078-0432.ccr-12-3289.

Greggio, Chiara, Filippo De Franceschi, Manuel Figueiredo-Larsen, Samy Gobaa, Adrian Ranga, Henrik Semb, Matthias Lutolf & Anne Grapin-Botton (2013). Artificial three-dimensional niches deconstruct pancreas development in vitro. Development, 140(21), 4452-4462, doi:10.1242/dev.096628. 
Link to Press Release 

Hattori, Naoko, Tohru Niwa, Kana Kimura, Kristian Helin & Toshikazu Ushijima (2013). Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. Nucleic Acids Research, 41(15), 7231-7239, doi:10.1093/nar/gkt528.

Helin, Kristian & Dashyant Dhanak (2013). Chromatin proteins and modifications as drug targets. Nature, 502(7472), 480-488, doi:10.1038/nature12751.

Hernebring, Malin, Asa Fredriksson, Maria Liljevald, Marija Cvijovic, Karin Norrman, John Wiseman, Henrik Semb & Thomas Nystrom (2013). Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28. Scientific Reports, 3, doi:10.1038/srep01381.

Hojfeldt, Jonas W., Karl Agger & Kristian Helin (2013). Histone lysine demethylases as targets for anticancer therapy. Nature Reviews Drug Discovery, 12(12), 917-930, doi:10.1038/nrd4154.

Jakobsen, Janus Schou, Johannes Waage, Nicolas Rapin, Hanne Cathrine Bisgaard, Fin Stolze Larsen & Bo Torben Porse (2013). Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries. Genome Research, 23(4), 592-603, doi:10.1101/gr.146399.112.

Jung, Hye Ryung, Simone Sidoli, Simon Haldbo, Richard R. Sprenger, Veit Schwammle, Diego Pasini, Kristian Helin & Ole N. Jensen (2013). Precision Mapping of Coexisting Modifications in Histone H3 Tails from Embryonic Stem Cells by ETD-MS/MS. Analytical Chemistry, 85(17), 8232-8239, doi:10.1021/ac401299w.

Kartikasari, Apriliana E. R., Josie X. Zhou, Murtaza S. Kanji, David N. Chan, Arjun Sinha, Anne Grapin-Botton, Mark A. Magnuson, William E. Lowry & Anil Bhushan (2013). The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation. Embo Journal, 32(10), 1393-1408, doi:10.1038/emboj.2013.78.

Katsumoto, Keiichi & Shoen Kume (2013). The Role of CXCL12-CXCR4 Signaling Pathway in Pancreatic Development. Theranostics, 3(1), 11-17, doi:10.7150/thno.4806.

Klauke, Karin, Visnja Radulovic, Mathilde Broekhuis, Ellen Weersing, Erik Zwart, Sandra Olthof, Martha Ritsema, Sophia Bruggeman, Xudong Wu, Kristian Helin, Leonid Bystrykh & Gerald de Haan (2013). Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nature Cell Biology, 15(4), 353-362, doi:10.1038/ncb2701.

Leucci, Eleonora, Francesca Patella, Johannes Waage, Kim Holmstrom, Morten Lindow, Bo Porse, Sakari Kauppinen & Anders H. Lund (2013). microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus. Scientific Reports, 3, doi:10.1038/srep02535.

Livigni, Alessandra & Joshua M. Brickman (2013). Oct4: The Final Frontier, Differentiation Defining Pluripotency. Developmental Cell, 25(6), 547-548, doi:10.1016/j.devcel.2013.06.002.

Livigni, Alessandra, Hanna Peradziryi, Alexei A. Sharov, Gloryn Chia, Fella Hammachi, Rosa Porter Migueles, Woranop Sukparangsi, Salvatore Pernagallo, Mark Bradley, Jennifer Nichols, Minoru S. H. Ko & Joshua M. Brickman (2013). A Conserved Oct4/POUV-Dependent Network Links Adhesion and Migration to Progenitor Maintenance. Current Biology, 23(22), 2233-2244, doi:10.1016/j.cub.2013.09.048. 
Link to Press Release

Malatesta, Martina, Cornelia Steinhauer, Faizaan Mohammad, Deo P. Pandey, Massimo Squatrito & Kristian Helin (2013). Histone Acetyltransferase PCAF Is Required for Hedgehog-Gli-Dependent Transcription and Cancer Cell Proliferation. Cancer Research, 73(20), 6323-6333, doi:10.1158/0008-5472.can-12-4660.

Morgani, Sophie M. & Joshua M. Brickman (2013). Survival of the fattest. eLife 2013;2:e01760,  doi:10.7554/eLife.01760.

Morgani, Sophie M., Maurice A. Canham, Jennifer Nichols, Alexei A. Sharov, Rosa Portero Migueles, Minoru S. H. Ko & Joshua M. Brickman (2013). Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions. Cell Reports, 3(6), 1945-1957, doi:10.1016/j.celrep.2013.04.034. Link to press release

Musacchio, Andrea & Kristian Helin (2013). Cell cycle, differentiation and disease Editorial overview. Current Opinion in Cell Biology, 25(6), 673-675, doi:10.1016/j.ceb.2013.09.003.

Norrman, Karin, Anna Strombeck, Henrik Semb & Anders Ståhlberg (2013). Distinct gene expression signatures in human embryonic stem cells differentiated towards definitive endoderm at single-cell level. Methods, 59(1), 59-70, doi:10.1016/j.ymeth.2012.03.030.

Qu, Xiaoling, Solomon Afelik, Jan Nygaard Jensen, Michael A. Bukys, Sune Kobberup, Martin Schmerr, Fan Xiao, Pia Nyeng, Maria Veronica Albertoni, Anne Grapin-Botton & Jan Jensen (2013). Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment. Developmental Biology, 376(1), 1-12, doi:10.1016/j.ydbio.2013.01.021.

Schuster, Mikkel B., Anne-Katrine Frank, Frederik O. Bagger, Nicolas Rapin, Jonas Vikesaa & Bo T. Porse (2013). Lack of the p42 form of C/EBP alpha leads to spontaneous immortalization and lineage infidelity of committed myeloid progenitors. Experimental Hematology, 41(10), 882-893, doi:10.1016/j.exphem.2013.06.003.

Seymour, Philip A. & Palle Serup (2013). Bulking Up on Beta Cells. New England Journal of Medicine, 369(8), 777-779, doi:10.1056/NEJMcibr1307038.

Thoren, Lina A., Cathrine K. Fog, Klaus T. Jensen, Natalija Buza-Vidas, Christophe Come, Anders H. Lund & Bo T. Porse (2013). PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells. Stem Cell Research, 11(3), 1129-1136, doi:10.1016/j.scr.2013.07.009.     

Torres, Cristina Morales, Anne Laugesen & Kristian Helin (2013). Utx Is Required for Proper Induction of Ectoderm and Mesoderm during Differentiation of Embryonic Stem Cells. Plos One, 8(4), e60020 doi:10.1371/journal.pone.0060020.

Vella, Pietro, Andrea Scelfo, SriGanesh Jammula, Fulvio Chiacchiera, Kristine Williams, Alessandro Cuomo, Alessandra Roberto, Jesper Christensen, Tiziana Bonaldi, Kristian Helin & Diego Pasini (2013). Tet Proteins Connect the O-Linked N-acetylglucosamine Transferase Ogt to Chromatin in Embryonic Stem Cells. Molecular Cell, 49(4), 645-656, doi:10.1016/j.molcel.2012.12.019.

Villegas, S. Nahuel, Michaela Rothova, Martin E. Barrios-Llerena, Maria Pulina, Anna-Katerina Hadjantonakis, Thierry Le Bihan, Sophie Astrof & Joshua M. Brickman (2013). PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix. Elife, 2, doi:10.7554/eLife.00806.001. 

Wu, Xudong, Jens Vilstrup Johansen & Kristian Helin (2013). Fbxl10/kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation. Molecular Cell, 49(6), 1134-1146, doi: 10.1016/j.molcel.2013.01.016.

2012 Til toppen

Bagger, Frederik Otzen, Nicolas Rapin, Kim Theilgaard-Mønch, Bogumil Kaczkowski, Johan Jendholm, Ole Winther & Bo Porse (2012). HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis. Blood, 119(26), 6394-6395, doi:10.1182/blood-2012-05-427310.

Choi, Eunyoung, Marine R. C. Kraus, Laurence A. Lemaire, Momoko Yoshimoto, Sasidhar Vemula, Leah A. Potter, Elisabetta Manduchi, Christian J. Stoeckert, Jr., Anne Grapin-Botton & Mark A. Magnuson (2012). Dual Lineage-Specific Expression of Sox17 During Mouse Embryogenesis. Stem Cells, 30(10), 2297-2308, doi:10.1002/stem.1192. 

Cortijo, Cedric, Mathieu Gouzi, Fadel Tissir & Anne Grapin-Botton (2012). Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis. Cell Reports, 2(6), 1593-1606, doi:10.1016/j.celrep.2012.10.016. 
Link to press release

Garbe, James C., Francois Pepin, Fanny A. Pelissier, Klara Sputova, Agla J. Fridriksdottir, Diana E. Guo, Rene Villadsen, Morag Park, Ole W. Petersen, Alexander D. Borowsky, Martha R. Stampfer, Mark A. LaBarge (2012). Accumulation of Multipotent Progenitors with a Basal Differentiation Bias during Aging of Human Mammary Epithelia. Cancer Research, 72(14), 3687-3701, doi:10.1158/0008-5472.can-12-0157.

Hammachi, Fella, Gillian M. Morrison, Alexei A. Sharov, Alessandra Livigni, Santosh Narayan, Eirini P. Papapetrou, James O'Malley, Keisuke Kaji, Minoru S. H. Ko, Mark Ptashne & Joshua M. Brickman (2012). Transcriptional Activation by Oct4 Is Sufficient for the Maintenance and Induction of Pluripotency. Cell Reports, 1(2), 99-109, doi:10.1016/j.celrep.2011.12.002. 
Link to press release

Horn, Signe, Sune Kobberup, Mette C. Jørgensen, Mark Kalisz, Tino Klein, Ryoichiro Kageyama, Moritz Gegg, Heiko Lickert, Jill Lindner, Mark A. Magnuson, Young-Yun Kong, Palle Serup, Jonas Ahnfelt-Rønne & Jan N. Jensen (2012). Mind bomb 1 is required for pancreatic beta-cell formation. Proceedings of the National Academy of Sciences of the United States of America, 109(19), 7356-7361, doi:10.1073/pnas.1203605109. 
Link to press release

Hasemann, Marie S., Mikkel B. Schuster, Anne-Katrine Frank, Kim Theilgaard-Mönch, Thomas Å. Pedersen, Claus Nerlov & Bo T. Porse (2012). Phosphorylation of Serine 248 of C/EBP alpha Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency. Plos One, 7(6), e38841, doi:10.1371/journal.pone.0038841.

Johannesson, Martina, Henrik Semb, Palle Serup & Mattias Hansson (2012). A Functional Assay for Putative Mouse and Human Definitive Endoderm using Chick Whole-Embryo Cultures. Stem Cell Research & Therapy, 2(128), 2-7. doi: 10.4172/2157-7633.1000128.

Kim, Jiyoung, Rene Villadsen, Therese Sørlie, Louise Fogh, Signe Z. Grønlund, Agla J. Fridriksdottir, Irene Kuhn, Fritz Rank, Vera Timmermans Wielenga, Hiroko Solvang, Paul A. W. Edwards, Anne-Lise Børresen-Dale, Lone Rønnov-Jessen, Mina J. Bissell & Ole William Petersen (2012). Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity. Proceedings of the National Academy of Sciences of the United States of America, 109(16), 6124-6129, doi:10.1073/pnas.1203203109.

Kraus, Marine R. C. & Anne Grapin-Botton (2012). Patterning and shaping the endoderm in vivo and in culture. Current Opinion in Genetics & Development, 22(4), 347-353, doi:10.1016/j.gde.2012.05.002.

Leth-Larsen, Rikke, Mikkel G. Terp, Anne G. Christensen, Daniel Elias, Thorsten Kuhlwein, Ole N. Jensen, Ole W. Petersen & Henrik J. Ditzel (2012). Functional Heterogeneity within the CD44 High Human Breast Cancer Stem Cell-Like Compartment Reveals a Gene Signature Predictive of Distant Metastasis. Molecular Medicine, 18(7), 1109-1121, doi:10.2119/molmed.2012.00091.

Serup, Palle (2012). Signaling pathways regulating murine pancreatic development. Seminars in Cell & Developmental Biology, 23(6), 663-672, doi:10.1016/j.semcdb.2012.06.004.

Serup, Palle, Carsten Gustavsen, Tino Klein, Leah A. Potter, Robert Lin, Nandita Mullapudi, Ewa Wandzioch, Angela Hines, Ashley Davis, Christine Bruun, Nina Engberg, Dorthe R. Petersen, Janny M. L. Peterslund, Raymond J. MacDonald, Anne Grapin-Botton, Mark A. Magnuson & Kenneth S. Zaret (2012). Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice. Disease Models & Mechanisms, 5(6), 956-966, doi:10.1242/dmm.009696.

Shih, Hung Ping, Janel L. Kopp, Manbir Sandhu, Claire L. Dubois, Philip A. Seymour, Anne Grapin-Botton & Maike Sander (2012). A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development, 139(14), 2488-2499, doi:10.1242/dev.078634.

Thompson, Nancy, Emilié Gesina, Peter Scheinert, Phillipp Bucher & Anne Grapin-Botton (2012). RNA Profiling and Chromatin Immunoprecipitation-Sequencing Reveal that PTF1a Stabilizes Pancreas Progenitor Identity via the Control of MNX1/HLXB9 and a Network of Other Transcription Factors. Molecular and Cellular Biology, 32(6), 1189-1199, doi:10.1128/mcb.06318-11.

Vaapil, Marica, Karolina Helczynska, Rene Villadsen, Ole W. Petersen, Elisabet Johansson, Siv Beckman, Christer Larsson, Sven Pahlman & Annika Jogi (2012). Hypoxic Conditions Induce a Cancer-Like Phenotype in Human Breast Epithelial Cells. Plos One, 7(9), e46543, doi:10.1371/journal.pone.0046543.

2011Til toppen

Fridriksdottir, Agla J. R., Ole W. Petersen & Lone Ronnov-Jessen (2011). Mammary gland stem cells: current status and future challenges. International Journal of Developmental Biology, 55(7-9), 719-729, doi:10.1387/ijdb.113373af.

Sigurdsson, Valgardur, Bylgja Hilmarsdottir, Hekla Sigmundsdottir, Agla J. R. Fridriksdottir, Markus Ringner, Rene Villadsen, Ake Borg, Bjarni A. Agnarsson, Ole William Petersen, Magnus K. Magnusson & Thorarinn Gudjonsson (2011). Endothelial Induced EMT in Breast Epithelial Cells with Stem Cell Properties. Plos One, 6(9), e23833, doi:10.1371/journal.pone.0023833.