DanStem Seminar by Meritxell Huch
Meritxell Huch, Wellcome Trust/ CRUK Gurdon Institute, Cambridge, UK
Title: Liver progenitor cells and hepatic organoids
The Hutch group aim is to understand the activation mechanism in order to harness it for therapeutic strategies. They have established a novel culture system for liver organoids, which allows the massive and infinite expansion of mouse liver cells into three-dimensional structures that resemble functional liver tissue. When transplanted into a mouse model of liver disease (‘FAH –/–’), these cells partially rescued the liver phenotype. The group has also work with pancreas cells and diseased human liver cells in culture, and are testing how well the models can represent in vivo pathology.