DanStem Seminar by Magali Suzanne
Title: From apoptotic cell dynamics to robust morphogenesis
One of the key aim in developmental biology is to fully understand how specific organs are formed and shaped. To do so, it is important to determine and characterize the cellular mechanisms involved in tissue shape remodeling such as epithelium folding, a basic morphogenetic event essential to transform simple 2D epithelial sheets into 3D structures. Although recent studies reveal the cellular mechanisms involved in cell shape dynamics, the initial cellular mechanisms that trigger and coordinate tissue folding remain largely unknown.