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Organ asymmetry: How the liver finds its place

Research by the Ober group, published in the latest issue of Developmental Cell, investigates the development of the liver and how it is positioned asymmetrically along the left-right body axis. During embryonic development, each internal organ is built by a group of specific progenitor cells. They first form at the midline of the embryo and move left or right to efficiently place each organ in the body cavity. Progenitor cells therefore need to be motile, receive directions where to move and finally interact with other cells as they navigate through the embryo to their final destination and establish the organ.