DanStem Seminar by Sirio Dupont
October 30, Sirio Dupont, Department of Molecular Medicine, University of Padova Title: New insights into ECM mechanotransduction pathways: Old friends, unexpected beginners
October 30, Sirio Dupont, Department of Molecular Medicine, University of Padova
Title: New insights into ECM mechanotransduction pathways: Old friends, unexpected beginners
30 October 2019, 12:15
Place: Nielsine Nielsen Auditorium
The Dupont group is interested in understanding how the mechanical properties of the extracellular matrix (ECM) regulate signaling pathways, gene transcription and other cellular processes, and how this is relevant for cell behavior, tissue homeostasis and disease. Their goal is to identify novel general principles in vitro, and to push their validation in vivo with the development of new animal models to study mechano-signaling in tissues. They use a multidisciplinary approach that includes custom-built compliant cell culture substrata, ECM micropatterning, cell micromanipulations, optical microscopy, molecular and cell biology techniques, transcriptional and bioinformatic analyses, proteomics, metabolomics, CRISPR/Cas9 modified cell lines, and genetically-modified mice, also thanks to multiple collaborations with colleagues in Italy and abroad.