19 May 2019

DanStem Seminar by Urban Lendahl, May 22, 2019, 12:15

seminar

May 22, 2019, Urban Lendahl, Karolinska Institutet Title: Dysregulated Notch signaling in disease Venue: Victor Haderup auditorium

May 22, 2019, Urban LendahlKarolinska Institutet
Title: Dysregulated Notch signaling in disease
Venue: Victor Haderup auditorium

The lab's long-term goal is to understand how the Notch signaling pathway operates at the molecular level, and how it controls cell fate decisions in normal development and disease.

They work on several aspects of Notch signaling. An important focus is to gain mechanistic insights into various steps in the pathway, ranging from endocytic processing of both ligands and receptor to establishing the immediate downstream signaling output through transcriptome analysis in different cell types.

The lab studies the role of Notch signaling in differentiation of various cell types, such as ES cells, myogenic and vascular progenitors. We also address the role of Notch in disease processes, notably in vascular disease and Alagille syndrome, as well as in cancer, with a particular focus on breast cancer.

Last, but not least, they try to unravel how Notch signaling cross-talks with other principal signaling mechanisms, and how such cross-talk allows for a larger number of physiological responses in a cell. They have previously demonstrated a cross-talk between Notch and BMP signaling, and, together with Lorenz Poellinger's group at CMB, provided evidence for integration between Notch and the cellular response to low oxygen (hypoxia).