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To address this question, the authors used mouse genetics, along with state-of-the-art cell biology and imaging approaches. The results exposed that selective cell affinities and surface-tension cell sorting are fundamental for pancreatic progenitor cells to enter and exit specific instructive niches actively. The adhesion protein p120-catenin governs this event by modulating E-cadherin membrane levels, promoting differences in cell boundaries and cell sorting into two separated groups of cells. Pancreatic progenitors expressing low p120-catenin levels form pro-acinar tips, and the pancreatic progenitors expressing high levels of p120-catenin stay in the trunk to become duct and endocrine cells. Thus, the surface-tensile discontinuity between the two groups of progenitor cells plays an essential role in shaping organ patterning followed by their commitment to specific lineages at the tip and trunk niches. It will be interesting to know in the future how the levels of p120-catenin are regulated, as well as the relative contributions of surface-tension properties along with the input of local signaling through cell contact cues in these developmental events."