Human Frontier Science Program (HFSP) grant to DanStem Professor Joshua Brickman – University of Copenhagen

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04 April 2012

Human Frontier Science Program (HFSP) grant to DanStem Professor Joshua Brickman

DanStem Professor Joshua Brickman receives three-year Program Research Grant from the Human Frontier Science Program (HFSP) for stem cell research

Together with Professor Adela Ben-Yakar from Department of Mechanical Engineering, University of Austin Texas, USA and Professor Naama Barkai , Department of Molecular Genetics and Department of Physics of Complex Systems, Weizmann Institute of Science, Israel, Joshua Brickman has received a grant in the amount of US$ 1.050.000/DKK 5,6 million for an interdisciplinary project focused on the Dynamic mechanisms regulating embryonic stem cell fate choice . The project combines world leading expertise in stem cell biology, mechanical engineering and physics.

The Human Frontier Science Programme (HFSP) supports frontier research in the life sciences. The programme is highly competitive with only 24 project granted out of nearly 800 phase 1 applications. Professor Brickman and his international team of researchers were ranked 3rd out of the 24 projects funded this year.

The highly ranked project focuses on the mechanisms governing cell fate choice in ES cells through a combination of emerging technologies within developmental stem cell biology, microfluidic manipulation of biological samples and integrated bioinformatics of high-throughput, mathematical modeling and genome-wide gene expression data. The goal of the project is to develop an integrated physical approach that will enable understanding how cells make decisions to differentiate in early embryos and embryonic stem (ES) cells.

Apart from expertise in developmental stem cell biology focused on mechanisms by which transcription factors regulate cell fate choice in the mesendoderm lineages, the project will include new optical and fluidic manipulation methods in micro-fabricated platforms to study the dynamic response of single cells. The experimental results will feed data into mathematical predictive models to ultimately describe the gene regulatory network involved in regulating the exit of ES cells from self-renewal into differentiation. For all three involved research groups, the proposed project presents a new challenge with huge potential for future research results.

About HFSP: HFSP is a funding program for frontier research in the life sciences, managed by the International Human Frontier Science Program Organization (HFSPO) based in Strasbourg.
HFSP grants are regarded as especially prestigious placing an emphasis on cutting-edge, risky projects pursued by internationally collaborating, interdisciplinary teams. Read more about the newly awarded projects at: