29 August 2019

New study shows that the KDM4 family is required for the normal long term production of blood cells

new study

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance, published in Blood, American Society of Hematology. 

In this study we investigate the long-term effects on the blood system by depleting the KDM4 family of epigenetic enzymes. This is an important question, since we have previously shown that the KDM4 family is required for the development and maintenance of acute myeloid leukemia, making these enzymes potential therapeutic targets for the treatment of leukemia. We find that combined loss of three KDM4 family members leads to the inactivation of genes that are essential for survival of hematopoietic stem cells and disrupts production of mature blood cells. Taken together, we show that the KDM4 family is required for the normal long‑term production of blood cells.

Agger, K., Nishimura, K., Miyagi, S., Messling, J.E., Rasmussen, K.D., Helin, K. (2019). The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance. Blood,. pii: blood.2019000855, doi: 10.1182/blood.2019000855.