The intestinal epithelium is a rapidly self-renewing tissue, where stem cells have been shown to play an important role during tissue replenishment. Deregulation of the natural process of tissue replenishment is associated with diseases such as cancer and ulceration, as well as regeneration following injury. We believe that molecular insights into how cells normally transition from a state characterized by tissue growth to a homeostatic state will be vital to understand, what happens at the cellular level during tissue regeneration and the development of cancer (Wong et al., 2012, Nature Cell Biology; Yui et al., 2018, Cell Stem Cell). Moreover, an enhanced understanding of how cells are maintained in a fetal state will enable us to harness these fetal stem cell for therapeutic purposes as exemplified previously (Fordham et al., 2013, Cell Stem Cell).
In order to address these key questions we use a number of different techniques including in vivo fate mapping to define cellular heritage, transcriptional and epigenetic analysis at both bulk populations and single cell level to identify candidate genes regulating cell fate changes, mouse models and organoid culture systems to identify signaling pathways that control cellular identity, transplantation techniques to address cell potential, bioengineered 3D cell culture scaffold to address how the environment affects cell fate and Crispr/Cas9 mediated genetic perturbation to address the role of specific genes and mutations (Page et al., 2013, Cell Stem Cell; Fordham et al., 2013, Cell Stem Cell; Yui et al., 2018, Cell Stem Cell). For more information on the Jensen group please follow the link http://www.bric.ku.dk/Research/jensen_group/
Project/The research project(s)
We are looking for an ambitious postdoctoral candidate with a strong background in cell biology and cell signaling. The candidate will participate in an ERC funded project aimed at deciphering the transcriptional networks that governs the transition between a fetal and adult stem cell state. The knowledge obtained from these studies will be integrated into a platform for cellular transplantation and inform the development of potential new treatment strategies for chronic ulceration of the lower gastrointestinal tract. To address these exciting questions the candidate will use organoid cultures, Crispr/cas9 technologies for genome engineering, bioengineering strategies, genetic mouse models and transplantation technologies.
Start: August 2018
Duration: 3 years
Hours per week: 37
We expect you to be a highly motivated and highly ambitious scientist with the following qualifications:
- A PhD in Life Sciences
- Excellent track record with at least 1 peer reviewed first authors paper in a high-impact journal
- A strong background in cellular biology is essential, and experience with transplantation technologies is an advantage
- The ability to independently envision, plan and execute a research project
- Excellent technical skills
- Excellent English skills written and spoken
For further information regarding the position, please contact Associate Professor Kim Jensen on e-mail email@example.com
Place of employment
The employment is at BRIC, University of Copenhagen. BRIC is located in the Biocenter, close to the centre of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and a number of core facilities shared between the 23 research groups at BRIC and the neighboring Finsen Laboratory. We have weekly journal clubs, data clubs, seminars with invited speakers and a young researchers club ASAP and our own PhD programme, MoMeD and our own postdoc programme
. BRIC actively participates in the European alliance, EU-life consisting of 13 excellent life science research institutions http://eu-life.eu/
Terms of salary and employment
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts 33,224 DKK/ca. 4,380 Euro plus pension. Depending on qualifications, a higher salary may be negotiated.
Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.
Your application must be submitted electronically by clicking ‘Apply now’ below or via BRIC’s website on http://www.bric.ku.dk/jobs/
. The application must include the following documents/attachments – all in PDF format:
- Motivated letter of application (max. one page) detailing the basis on which the applicant scientific qualifications meet the requirements for this position.
- CV incl. education, work/research experience, language skills and other skills relevant for the position.
- A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
- List of publications.
Letters of recommendation
Furthermore, the applicant should provide two letters of recommendation. To be taken into consideration, the letter must be signed by the supporting person on paper with institutional letter head and in PDF-format. The letters should be received before deadline on firstname.lastname@example.org with subject “name candidate-postdoc2018”; preferably by the supporting person. Please make sure that an easy match between the recommendation letter and the individual applicant is possible.
Application deadline: April 20th, 2018.
We reserve the right not to consider material received after the deadline, and not to consider applications or letters of recommendation that do not live up to the above-mentioned requirements.
The further process
Shortlist: After expiry of the application deadline, the superior with power to appoint selects a number of applicants for assessment on the advice of the Appointments Committee. All applicants are immediately notified whether their application has been passed for assessment. Applicants who were not passed for assessment should not expect further with regard to their application unless the shortlist is revised.
Assessment: The selected applications will be assessed according to the Ministry Order on the Appointment of Academic Staff at Universities 2012 and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritized assessment of the academic qualifications and experience with respect to the above mentioned area of research, techniques, skills and other requirements listed in the advertisement.
BRIC and University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.