11 December 2017

Postdoctoral Fellowship in the Cell Biology of Tubulogenesis and its impact on Cell Differentiation

job opportunity

The aim of this project is to study the cellular and molecular mechanisms of tubulogenesis and its role in balancing cell proliferation and differentiation of multipotent progenitors in the developing pancreas.

The Novo Nordisk Foundation Center for Stem Cell Biology – DanStem has been established as a result of a series of international recruitments coupled with internationally recognized research groups focused on insulin producing beta cells and cancer research already located at the University of Copenhagen. DanStem addresses basic research questions in stem cell and developmental biology and has activities focused on the translation of promising basic research results into new strategies and targets for the development of new therapies for cancer and chronic diseases such as diabetes and liver failure. Find more information about the Center at http://danstem.ku.dk/.   
Our research: 
Our lab has two main goals 1) to understand how cell polarity and tissue architecture control cell fate specification (see Kesavan et al, Cell 2009 and Löf-Öhlin et al, NCB 2017) and 2) to translate this knowledge into efficient and reliable strategies for regenerative medicine in diabetes (Löf-Öhlin et al, NCB 2017 and Ameri et al, Cell Rep 2017). These objectives are applied, primarily, to our organ of choice – the pancreas. To explore our goals, we use a combination of mouse pancreatic epithelium and human pluripotent stem cells as model systems. Functioning as an interdisciplinary lab we work to combine knowledge from multiple systems; through the combinatorial use of animal models, stem cells and computer modelling.  
The aim of this project is to study the cellular and molecular mechanisms of tubulogenesis and its role in balancing cell proliferation and differentiation of multipotent progenitors in the developing pancreas. The postdoc will use the mouse model and confocal and multiphoton 3D microscopy of both live and stained specimens to investigate these questions, as part of a team of imaging, developmental biology and image analyses experts.
The position is for 2 years with possible extension. The employment is planned to start beginning of 2018 or upon agreement with the chosen candidate. 
  • A PhD degree in life sciences. Postdoctoral experience is a merit. 
  • Documented hands-on experience in developmental biology and genetics of the mouse 
  • Documented experience in advanced imaging and image analysis. Experience with segmentation and tracking in large 3D datasets and/or programming skills is a merit. 
  • Good record of peer reviewed scientific publications and grant writing skills. 
  • An interest in cross-disciplinary research. Experience in the same is a merit 
  • Excellent English skills written and spoken 
Employment Conditions: 
The terms of employment are set according to the Agreement between the Ministry of Finance and The Danish Confederation of Professional Associations or other relevant professional organization. The position will be at the level of postdoctoral fellow and the basic salary according to seniority is 32.700-34.400 DKK/month. A supplement could be negotiated, dependent on the candidate´s experiences and qualifications. In addition a monthly contribution of 17.1% of the salary is paid into a pension fund. Applicants that are recruited from abroad may be eligible for a special researcher taxation scheme. In all cases, the ability to perform the job will be the primary consideration, and thus we encourage all - regardless of their personal background and status - to apply.
For further information contact Professor Henrik Semb, Henrik.semb@sund.ku.dk
Foreign applicants may find the following links useful: www.ism.ku.dk (International Staff Mobility) and www.workingconditions.ku.dk
Application Instruction: 

The application must be submitted in English, by clicking on “Apply online” below. Only online applications will be accepted. The closing date for applications is 23.59pm, January 22, 2018 
The application must include:
  • Cover letter detailing the basis on which the applicant scientific qualifications meet the requirements for this position. 
  • Curriculum vitae. 
  • List of references (full address, incl. email and phone number) 
  • Diplomas – all relevant certificates. 
  • List of publications. 
Application procedure: 
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on his/her assessment. You may read about the recruitment process at http://employment.ku.dk. DanStem and The University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates, regardless of personal background.
Apply online 
Link for general info on the recruitment process: http://employment.ku.dk/faculty/recruitment-process
Founded in 1479, the University of Copenhagen is the oldest university in Denmark. With 37,000 students and 9,000 employees, it is among the largest universities in Scandinavia and one of the highest ranking in Europe. The University consists of six faculties, which cover Health and Medical Sciences, Humanities, Law, Science, Social Sciences and Theology. 
Apply by clicking on the following link: SØG STILLINGEN