DanStem Seminar by Scott E. Fraser- August 10, 2017 16:00 – University of Copenhagen

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27 July 2017

DanStem Seminar by Scott E. Fraser- August 10, 2017 16:00


August 10, 2017, Scott E. Fraser, University of Southern California, Title: Eavesdropping on the molecular signatures of embryonic development

Scott E. Fraser, Director of the Translational Imaging Center, Provost Professor of Biology and Bioengineering, University of Southern California

Title: Eavesdropping on the molecular signatures of embryonic development

Time: 10 August 2017, 16:00

Place: Mærsk Tower, Seminar room 15th floor.

"Imaging offers a means to draw upon the growing body of high-throughput molecular data to better understand the underlying cellular and molecular mechanisms of embryonic development; however, it is challenged by tradeoffs between speed, resolution, field of view and the photon budget.  We are advancing this tradeoff by constructing two-photon light-sheet microscopes, combining the deep penetration of two-photon microscopy and the speed of light sheet microscopy, permitting cell and molecular imaging with sufficient speed and resolution to generate unambiguous tracing of cells and signals in intact systems.  In parallel we are refining imaging tools for multispectral and fluorescence lifetime imaging for examining both exogenous labels and intrinsic cell/tissue differences.  In addition, we have created a new generation of multispectral image analysis tools that exceed the performance of our previous work on Linear Unmixing by orders of magnitude in speed, error propagation and accuracy.  These new analysis tools permit rapid and unambiguous analysis of Rainbow and other multi-color labeled specimens.  Finally, we are deploying new tools for following receptor binding and multimerization in response to signals, offering molecular sensing without molecular imaging.  Combined, these tools offer the multi-dimensional imaging required to follow key events in as they take place, and allow us to use variance as an experimental tool rather than a limitation".  

All are welcome, no registration is needed.