6 July 2020

The New England Journal of Medicine covers the Serup group recent study

Science and medicine

Research by the Serup group shows how the Notch signalling pathway works when the pancreas forms as the fetus develops. This discovery may lead to new opportunities to cure people with diabetes and understand how pancreatic cancer develops.

The New England Journal of Medicine (NEJM), the world’s leading medical journal, picked up on a recent original article published by DanStem researchers in Developmental Cell (Seymour et al., 2020). In their regular section on “Clinical Implications of Basic Research” NEJM published a commentary (Pajvani and Sussel, 2020) highlighting the novelty of the DanStem research and the clinical perspectives of their findings. The commentary notes that the new insights gained will likely be of benefit to studies of pancreatic cancer, the function of mature insulin-producing beta cells, and for a more efficient in vitro production of beta cells from human embryonic stem cells that is aimed at providing transplantable cells for diabetes patients.

Pajvani, U.B., and Sussel, L. (2020). An Ultradian Notch in Beta-Cell Development. N Engl J Med 383, 80-82.

Seymour, P. A., Collin, C. A., Egeskov-Madsen, A. la R., Jørgensen, M. C., Shimojo, H., Imayoshi, I., de Lichtenberg, K. H., Kopan, R., Kageyama, R., and Serup, P. (2020). Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Developmental Cell. doi: 10.1016/j.devcel.2020.01.015

About the Serup group at DanStem