Visiting Postdoc Fellowship at Stanford Bio-X" to Silas Boye Nissen
The Novo Nordisk Foundation awards young, ambitious researchers for a Visiting Scholar/ Visiting Postdoc Fellowship in interdisciplinary research with a biomedical or biotechnological focus at the highest international level. The fellowship offers an opportunity to carry out a research project at Stanford University in California, USA, under the Stanford Bio-X Institute, and at a university or other public or non-profit research institution in Denmark.
Bio-X is Stanford's pioneering interdisciplinary biosciences institute, bringing together biomedical and life science researchers, clinicians, engineers, physicists, and computational scientists to unlock the secrets of the human body..
Project title: "Mechanism of core planar cell polarity complex function elucidated with single-molecule methods"
"During embryonic development, many epithelial cells must be oriented relative to their surroundings. Orienting the cells requires activity of the planar cell polarity (PCP) signaling pathway. This pathway provides directionality within the layer of cells and distinguishes one end of the developing tissue from the other. The molecular mechanism underlying PCP signaling remains poorly understood. I hypothesize that there exists a critical, switch-like transition (ultrasensitivity) between cells that do not achieve orientation and those that acquire directionality. I propose to study how molecular interactions produce this response with advanced microscopy techniques to image single-molecule interactions inside living cells. To do this, I will use fruit flies that have a suite of highly developed genetic tools and exhibit a well-characterized PCP patterning in their wings. Acquiring this knowledge will contribute to preventing developmental anomalies such as heart and neural tube defects". - Explains Silas Boye Nissen
During the first three years Silas will be hosted at Alexander Dunn lab, Department of Chemical Engineering, Stanford University and Jeffrey D. Axelrod lab, Department of Pathology, Stanford University School of Medicine, where the host supervisor will be Professor Palle Serup from DanStem.