Staff – University of Copenhagen

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Lydie Flasse

Lydie Flasse

Assistant professor

The differentiation of pancreatic cells occurs largely from polarized
progenitors aligned in ducts. Using in vivo investigations in mice we are
investigating the impact of cellular polarization on the cells’ fate
by focusing on the planar cell polarity (PCP) which refers to the collective
orientation of cells within the epithelial plane. We aim to decipher the
molecular mechanisms by which the PCP pathway controls pancreatic cell differentiation. We are
using genetically impaired mice to study the function of essential protein involved in the PCP pathway and determine which are the molecular and cellular mechanisms
involved downstream of this signaling pathway. These experiments are complemented by a microscopic visualization of  the PCP pathway components in space

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