Anne Grapin-Botton – University of Copenhagen

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Anne Grapin-Botton

Professor of Developmental Biology

Link to the Grapin-Botton Laboratory Homepage

Research Profile

Anne Grapin-Botton has a background in developmental biology and initially studied nervous system and endoderm development. Her laboratory is currently focused on pancreas development with the overall goals of understanding how pancreatic cells differentiate during embryogenesis, and determining what limits the pancreatic cells’ regeneration in adults. More specifically, Professor Grapin-Botton and her group investigate the impact of the cellular and organ architecture on the cells’ fate choices and the dynamics of decision processes.

Awards and Honours

Anne Grapin-Botton is the recipient of several awards and grants including, a Human Frontiers Science Program (HFSP) Long Term Fellowship. Professor Grapin-Botton is a Beta Cell Biology Consortium Investigator, and also serves on the editorial board of the journal Mechanisms and Development.

Key Recent Discoveries

Kim, Yung Hae, Hjalte List Larsen, Paul Rue, Laurence A. Lemaire, Jorge Ferrer & Anne Grapin-Botton (2015). Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas. PLoS Biology, 13(3), e1002111, doi:10.1371/journal.pbio.1002111.

Lemaire, Laurence A., Joan Goulley, Yung Hae Kim, Solenne Carat, Patrick Jacquemin, Jacques Rougemont, Daniel B. Constam & Anne Grapin-Botton (2015). Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis. Development, 142(5), 858-870, doi: 10.1242/dev.114611.

Greggio, Chiara, Filippo De Franceschi, Manuel Figueiredo-Larsen, Samy Gobaa, Adrian Ranga, Henrik Semb, Matthias Lutolf & Anne Grapin-Botton (2013). Artificial three-dimensional niches deconstruct pancreas development in vitro. Development, 140(21), 4452-4462, doi:10.1242/dev.096628. 

Cortijo, Cedric, Mathieu Gouzi, Fadel Tissir & Anne Grapin-Botton (2012). Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis. Cell Reports, 2(6), 1593-1606, doi:10.1016/j.celrep.2012.10.016. 

Johansson, Kerstin A., Umut Dursun, Nathalie Jordan, Guoqiang Gu, Friedrich Beermann, Gérard Gradwohl & Anne Grapin-Botton (2007). Temporal Control of Neurogenin3 Activity in Pancreas Progenitors Reveals Competence Windows for the Generation of Different Endocrine Cell Types. Developmental Cell, 12(3), 457-465, doi: 10.1016/j.devcel.2007.02.010.