Associate Professor of Stem Cell Biology
Elke Ober is a developmental biologist and holds a Ph.D. from the Max-Planck-Institut für Entwicklungsbiologie, Tübingen (Germany). After obtaining a PhD Elke pursued postdoctoral research at the University of California San Francisco in the USA until 2005. From 2005 to October 2013, Elke Ober was a program leader at the National Institute for Medical Research in London. Using zebrafish as a model system her research has focused on studying mechanisms that control the specification of liver progenitors form the foregut endoderm. In this work she has also focused on Wnt signaling in liver formation. A current research interest is to compare molecular mechanisms in liver development with mechanisms in regeneration.
Lonowski, L.A., Narimatsu, Y., Riaz, A., Delay, C.E., Yang, Z., Niola, F., Duda, K., Ober, E.A., Clausen, H., Wandall, H., Hansen, S.H., Bennett, E.P., and Frödin, M. (2017). Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis. Nature Protocols 12, 581-603, doi:10.1038/nprot.2016.165.
Wang, S., Miller, S.R., Ober, E.A. and Sadler, K.C. (2017). Making it new again: Insight into liver development, regeneration, and disease from zebrafish research. Current Topics in Developmental Biology 124, 161-195, doi:10.1016/bs.ctdb.2016.11.012.
Cayuso, J., Dzementsei, A., Fischer, J.C., Karemore, G., Caviglia, S., Bartholdson, J., Wright, G.J. and Ober E.A. (2016). EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality. Developmental Cell 39, 316-328, doi:10.1016/j.devcel.2016.10.009. Recommended by the faculty of 1000
Ober, E.A. and Grapin-Botton, A. (2015). At new heights - endodermal lineages in development and disease. Development 142, 1912-1917, doi: 10.1242/dev.121095.
Koltowska, K., Apitz, H., Stamataki, D., Hirst, E.M.A., Verkade, H., Salecker, I., and Ober, E.A. (2013). Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis. Development 140, 1912-1918, doi:10.1242/dev.093583.
Poulain, M. and Ober, E.A. (2011). Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development. Development 138, 3557-3568, doi:10.1242/dev.055921.