Elke Ober – University of Copenhagen

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Elke Ober

Associate Professor of Stem Cell Biology

Link to the Ober Laboratory Homepage

Research Profile

Elke Ober is a developmental biologist and holds a Ph.D. from the Max-Planck-Institut für Entwicklungsbiologie, Tübingen (Germany). After obtaining a PhD Elke pursued postdoctoral research at the University of California San Francisco in the USA until 2005. From 2005 to October 2013, Elke Ober was a program leader at the National Institute for Medical Research in London. Using zebrafish as a model system her research has focused on studying mechanisms that control the specification of liver progenitors form the foregut endoderm. In this work she has also focused on Wnt signaling in liver formation. A current research interest is to compare molecular mechanisms in liver development with mechanisms in regeneration.

Selected publications:

Lonowski, Lindsey A., Yoshiki Narimatsu, Anjum Riaz, Catherine E. Delay, Zhang Yang, Francesco Niola, Katarzyna Duda, Elke A. Ober, Henrik Clausen, Hans H. Wandall, Steen H. Hansen, Eric P. Bennett & Morten Frödin (2017). Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysisNature Protocols, 12(3), 581-603, doi:10.1038/nprot.2016.165.

Wang, Shuang, Sophie R. Miller, Elke A. Ober, Kirsten C. Sadler (2017). Making it new again: Insight into liver development, regeneration, and disease from zebrafish researchCurrent topics in developmental Biology, 124, 161-195, doi: 10.1016/bs.ctdb.2016.11.012.

Cayuso, Jordi, Aliaksandr Dzementsei, Johanna C Fischer, Gopal Karemore, Sara Caviglia, Josefin Bartholdson, Gavin J Wright & Elke A Ober (2016). EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality. Developmental Cell, 39(3), 316-328, doi:10.1016/j.devcel.2016.10.009.

Ober, Elke A. & Anne Grapin-Botton (2015). At new heights - endodermal lineages in development and diseaseDevelopment, 142(11), 1912-1917, doi:10.1242/dev.121095.

Koltowska, Katarzyna, Holger Apitz, Despina Stamataki, Elizabeth M. A. Hirst, Heather Verkade, Iris Salecker & Elke A. Ober (2013). Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis. Development, 140(9), 1912-1918, doi:10.1242/dev.093583.

Poulain, Morgane & Elke A. Ober (2011). Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development. Development, 138(16), 3557-3568, doi:10.1242/dev.055921.