Bo Porse

Link to the Porse Group page

Bo Porse is Head of the Finsen Laboratory at University of Copenhagen Hospital, Group Leader at the Biotech Research and Innovation Centre (BRIC) and Professor in Molecular Oncology at the Department of Clinical Medicine at the University of Copenhagen.

Awards and Honours

Bo Porse has received several accolades for his work including a Young Research Leader Stipend from the Danish Medical Research Council and the Junior Research Prize from the Danish Cancer Society.

Gårdejer Ingemann Petersen og hustrus” honorary prize Danish Association for Cancer Research.

Research Profile

Bo Porse and his research group are studying cancer relevant processes from a stem cell centric viewpoint. His overarching research goal is to define differences and similarities between normal and cancerous stem cells, with the hope of facilitating therapeutic targeting of the latter. His work is currently concentrating on characterizing genes and pathways that govern the self renewal of normal hematopoietic stem cells, as these are often high-jacked by leukemic stem cells. In particular, his focus is on transcription factors and RNA processing factors regulating self renewal in normal hematopoietic stem cells as these are frequently de-regulated in leukemic stem cells. Recently, his group also embarked on large-scale collaborative gene expression profiling studies of AML patients, with the aim of identifying genes and pathways that contribute to the maintenance of cancer stem cells in this disease.

Key Recent Discoveries

Lauridsen, F.K.B., Jensen, T.L., Rapin, N., Aslan, D., Wilhelmson, A.S., Pundhir, S., Rehn, M., Paul, F., Giladi, A., Hasemann, M.S., Serup, P., Amit, I., and Porse, B.T. (2018). Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment. Cell Reports 24, 766-780, doi:10.1016/j.celrep.2018.06.057.

Pundhir, S., Bratt Lauridsen, F.K., Schuster, M.B., Jakobsen, J.S., Ge, Y., Schoof, E.M., Rapin, N., Waage, J., Hasemann, M.S., and Porse, B.T. (2018). Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors. Cell Reports 23, 2744-2757, doi:10.1016/j.celrep.2018.05.012.

Knudsen, K.J., Rehn, M., Hasemann, M.S., Rapin, N., Bagger, F.O., Ohlsson, E., Willer, A., Frank, A.K., Sondergaard, E., Jendholm, J., Thoren, L., Lee, J., Rak, J., Theilgaard-Monch, K., and Porse, B.T. (2015). ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation. Genes and development 29, 1915-1929, doi:10.1101/gad.268409.115.

Willer, A., Jakobsen, J.S., Ohlsson, E., Rapin, N., Waage, J., Billing, M., Bullinger, L., Karlsson, S., and Porse, B.T. (2014). TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia. Leukemia 29, 1018-1031, doi:10.1038/leu.2014.307.

Rapin, N., Bagger, F.O., Jendholm, J., Mora-Jensen, H., Krogh, A., Kohlmann, A., Thiede, C., Borregaard, N., Bullinger, L., Winther, O., Theilgaard-Monch, K., and Porse, B.T. (2014). Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients. Blood 123, 894-904, doi:10.1182/blood-2013-02-485771.

Ohlsson, E., Schuster, M.B., Hasemann, M., and Porse, B.T. (2016). The multifaceted functions of C/EBPalpha in normal and malignant haematopoiesis. Leukemia 30, 767-775, doi:10.1038/leu.2015.324.

Hasemann, M.S., Lauridsen, F.K., Waage, J., Jakobsen, J.S., Frank, A.K., Schuster, M.B., Rapin, N., Bagger, F.O., Hoppe, P.S., Schroeder, T., and Porse, B.T. (2014). C/EBPalpha is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors. PLoS Genet 10, e1004079, doi:10.1371/journal.pgen.1004079.