Palle Serup – University of Copenhagen

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Palle Serup

Professor of Developmental Biology

palle.serup@sund.ku.dk

Link to the Serup Laboratory Homepage

Research Profile

Palle Serup and his research group have during recent years focused on the role of cell to cell signalling in the control of pancreatic endocrine development and on the role of key transcription factors in the regulation of beta cell specification. Also, he has, as the principal investigator of both EU and NIH sponsored projects, together with teams of European and American scientists been instrumental in expanding our knowledge of intercellular signalling events and cell-autonomous transcription factors in pancreatic development. Palle Serup is a Research Collaborator of the Danish Diabetes Academy and has authored more than 100 scientific papers including 85 peer-reviewed original papers. His h-index is 46.

Awards and Honours

Palle Serup has received a postdoctoral fellowship from The Clayton Foundation for Research, Austin, Texas in 1990. For his contributions as grant reviewer Palle Serup has received the Mary Jane Kugel Award from the Juvenile Diabetes Research Foundation (JDRF). He has served on the Medical Science Review Committee of the JDRF since 2001, and from 2007 to 2010 as Chairman of the committee for Innovation grants.
In 2010 Palle Serup was appointed Adjunct Professor in Developmental Biology of pancreas and islet cell differentiation at University of Southern Denmark.

Key Recent Discoveries

Seymour, Philip A, Caitlin A Collin, Mette C Jorgensen, Itaru Imayoshi, Ryoichiro Kageyama & Palle Serup (2018). Dll1 and Jag1 are Differentially Required to Specify Proximal and Distal Pancreatic Duct Compartments. bioRxiv 336529, doi: 10.1101/336529

de Lichtenberg, Kristian Honnens, Nina Sofi Funa, Nikolina Nakic, Jorge Ferrer, Zengrong Zhu, Danwei Huangfu & Palle Serup (2018). Genome- wide identification of HES1 target genes uncover novel roles for HES1 in pancreatic developmentbioRxiv 335869, doi: 10.1101/335869

Jorgensen MC, de Lichtenberg KH, Collin CA, Klinck R, Ekberg JH, Engelstoft MS, Lickert H & Serup P (2018). Neurog3-dependent Pancreas Dysgenesis Causes Ectopic Pancreas in Hes1 Mutants. Development, in press

Horn, Signe, Sune Kobberup, Mette C. Jørgensen, Mark Kalisz, Tino Klein, Ryoichiro Kageyama, Moritz Gegg, Heiko Lickert, Jill Lindner, Mark A. Magnuson, Young-Yun Kong, Palle Serup*, Jonas Ahnfelt-Rønne* & Jan N. Jensen (2012). Mind bomb 1 is required for pancreatic β-cell formation. PNAS 109(19), 7356-7361, doi: 10.1073/pnas.1203605109. *Corresponding author

Ahnfelt-Rønne, Jonas, Mette C. Jørgensen, Rasmus Klinck, Jan N. Jensen, Ernst-Martin Füchtbauer, Tye Deering, Raymond J. MacDonald, Chris V.E. Wright, Ole D. Madsen & Palle Serup (2012). Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. Development, 139, 39-45, doi: 10.1242/dev.071761.