Surveillance for Secure Differentiation – University of Copenhagen

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16 January 2017

Surveillance for Secure Differentiation

Hamilton, William B. & Joshua M. Brickman (2017). Surveillance for Secure Differentiation. Cell Stem Cell, 20(1), 3-5, doi:10.1016/j.stem.2016.12.011.


The precise place and time where embryonic differentiation begins is regulated by regionalized signaling. In this issue of Cell Stem CellWang et al. (2017) investigate how converging Wnt and Nodal signals promote mesendoderm through a p53, Wnt3 feed-forward loop, pointing to a mechanism by which cells gauge time and fitness during differentiation.