Research (2011-2022)

Uncovering the mechanisms and coordination of stem / progenitor cell self-renewal and differentiation is essential to gaining a fundamental understanding of tissue and organ development and their potential use in regenerative medicine. Therefore, DanStem research aims to solve complex problems in stem cell and developmental biology spanning early embryonic development and organogenesis through advanced disease development and cell and drug-based therapies.

Through an increasingly quantitative approach with advanced imaging and single cell analyzes, our researchers are teasing out the details of how specific cues transduce to gene regulatory events, such as modulation of epigenetic states or gene transcription, to control stem cell behavior. These studies allow us to unravel fundamental issues in the field and facilitate the translation of novel insights into medical practice especially in the areas of diabetes and hematological cancers. 

DanStem Research Areas

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Synergy and collaboration are essential for progress and success in our research areas. We value interactions within DanStem, as well as with scientists of the NNF Copenhagen Bioscience Cluster , the greater Danish bioscience and clinical communities and with the international scientific milieu.  

Read more about our research programs:

The Ferretti Group 
Lineage Choice and Mesodermal Competence

The group aims to understand how transcription factors and signaling pathways interact to define a precise cell fate. Read more about Ferretti Group

The Ober Group
Liver Development and Regeneration

The group aims to understand how a functional organ is built from a population of self-organizing progenitor cells. Read more about Ober Group

The Semb Group
Human Stem Cell Biology

The group aims to understand how cell polarity and tissue architecture control cell fate specification and to translate this knowledge into strategies for regenerative medicine in diabetes. Read more about Semb Group