DanStem Research – University of Copenhagen

DanStem > Research

DanStem Research

Uncovering the mechanisms and coordination of stem/progenitor cell self-renewal and differentiation is essential to gaining a fundamental understanding of tissue and organ development and their potential use in regenerative medicine. Therefore, DanStem research aims to solve complex problems in stem cell and developmental biology spanning early embryonic development and organogenesis through advanced disease development and cell and drug-based therapies.

Through an increasingly quantitative approach with advanced imaging and single cell analyses, our researchers are teasing out the details of how specific cues transduce to gene regulatory events, such as modulation of epigenetic states or gene transcription, to control stem cell behavior. These studies allow us to unravel fundamental issues in the field and facilitate the translation of novel insights into medical practice especially in the areas of diabetes and hematological cancers. 

Synergy and collaboration are essential for progress and success in our research areas. We value interactions within DanStem, as well as with scientists of the NNF Copenhagen Bioscience Cluster, the greater Danish bioscience and clinical communities and with the international scientific milieu.  

Read more about our research programs:

The Brickman Group

Transcription, Potency and Patterning

The group aims to understand the transcriptional basis for early embryonic lineage specification. Read more.

The Ferretti Group 
Lineage Choice and Mesodermal Competence

The group aims to understand how transcription factors and signaling pathways interact to define a precise cell fate. Read more..

The Grapin-Botton Group
Endoderm and Pancreas Development

The group aims to understand how progenitor cells of the pancreas read architectural cues to choose between expansion and differentiation. Read more.

The Helin Group
Molecular mechanisms leading to cancer 

The group aims to provide novel insights into mechanisms regulating transcription, stem cell identity, and differentiation. Read more.

The Jensen Group
Cell fate control during development, homeostasis and disease

The group aims to understand how stem cell fate is controlled at the molecular level during development and tissue homeostasis, and in disease. Read more.

The Kirkeby Group
Human Neural Development

The group aims to understand the detailed processes that control human brain development.  Read more.

 

The Ober Group
Liver Development and Regeneration

The group aims to understand how a functional organ is built from a population of self-organizing progenitor cells.  Read more.

The Petersen Group

The group aims to dissect stem cell hierarchies in the normal breast and in breast cancer, with a view to finding the cell of origin in different breast cancer subtypes.  Read more.

The Porse Group
Stem cells in normal and malignant hematopoiesis

The group aims to better understand the role of transcription factors in normal and malignant hematopoiesis. Read more.

The Sedzinski Group
Mechanics of Tissue Homeostasis

The group aims to understand the mechanics of epithelial tissue homeostasis and morphogenesis. Read more.

The Semb Group
Human Stem Cell Biology

The group aims to understand how cell polarity and tissue architecture control cell fate specification and to translate this knowledge into strategies for regenerative medicine in diabetes. Read more.

The Serup Group
Developmental Biology of The Pancreas

The group aims to understand the developmental biology of the pancreas through the study of signaling events that regulate growth and differentiation of pancreatic cell types. Read more.

Program in Translational Diabetes Research

The program aims to initiate new strategies for bringing advanced stem cell-derived therapy to a broad population of type 1 diabetes patients, through a plan for scalable engineering of human pluripotent stem cell-derived pancreatic islet-like cellular grafts for future type 1 diabetes cell therapy trials. Read more.

Program in Translational Hematology

the program aims to improve the immediate and long-term outcome for blood cancer patients by coordinating and strengthening ongoing blood cancer research into a program pursuing research questions and integrating results from bench-to-bedside and bedside-to-bench.  Read more.