Luis Arnes Perez

Associate Professor of Developmental and Cancer Biology 

Link to the Arnes Group Homepage 

ORCID: 0000-0002-4158-8301

Research Profile

Luis’s professional career has continually been focused on the study of pancreas biology and related disorders. After completing a Ph.D. in Genetics and Cellular Biology at the Autonoma University in Madrid, he joined the laboratory of Dr. Lori Sussel at Columbia University to study the transcriptional programs that regulate the specification of pancreatic lineages. These studies fostered his interest in understanding how transcriptional regulators of pancreas development contribute to the maintenance of cellular identity and how their dysregulation contributes to diseases. He was the recipient of the Berrie Scholar Award at Columbia University.

He then received a prestigious postdoctoral fellowship from the Juvenile Diabetes Research Foundation (JDRF) to continue his research. He discovered that long non-coding RNAs are necessary for the control of developmental competence in the differentiation of pancreatic lineages. His postdoctoral work in the Sussel lab made a paradigm-shift in pancreas developmental studies and was pioneer in identifying non-coding regulators of lineage specification.

After being trained in pancreas development and mouse genetics, he received a Transition Award from JDRF and an Interdisciplinary Research Award from Columbia University to carry out research in the laboratories of Prof. Raul Rabadan and Dr. Ken Olive at Columbia University. Here, Luis continued his studies in transcriptional regulation of cellular identity in the context of cancer and human genetics. His work showed that cell fate transition in the progression of pancreatic ductal adenocarcinoma is dynamic and regulated at least in part by non-coding RNAs.

The Arnes lab at DanStem is now focused on understanding the non-coding regulation of cellular plasticity and tumor progression in vivo

Awards and Honours

Luis Arnes is the recipient of personal awards and grants including:

  • Advance Postdoctoral Fellowship and Transition Award from the Juvenile Diabetes Research Foundation.
  • Interdisciplinary Research Initiative Seed, Pilot Award from the Center for Cancer Systems Therapeutic and Russel Berrie Foundation Scholar in Diabetes Research from Columbia University.
  • Interstellar Award from the Japan Agency of Medical Research.

Selected Publications

Arnes, L.*#, Liu, Z.#, Wang, J.#, Carlo Maurer, H., Sagalovskiy, I., Sanchez-Martin, M., Bommakanti, N., Garofalo, D. C., Balderes, D. B., Sussel, L., Olive, K. P.*, Rabadan, R*. (2018). Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma. Gut. doi:10.1136/gutjnl-2017-314353. *joint senior author #joint first author

Arnes, L., Akerman, I., Balderes, D. A., Ferrer, J., & Sussel, L. (2016). betalinc1 encodes a long noncoding RNA that regulates islet beta-cell formation and function. Genes Dev, 30(5), 502-507. doi:10.1101/gad.273821.115

Arnes, L., & Sussel, L. (2015). Epigenetic modifications and long noncoding RNAs influence pancreas development and function. Trends Genet, 31(6), 290-299. doi:10.1016/j.tig.2015.02.008

Arnes, L., Hill, J. T., Gross, S., Magnuson, M. A., & Sussel, L. (2012). Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. PLoS One, 7(12), e52026. doi:10.1371/journal.pone.0052026

Arnes, L., Leclerc, K., Friel, J. M., Hipkens, S. B., Magnuson, M. A., & Sussel, L. (2012). Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis, 50(8), 612-624. doi:10.1002/dvg.22037