Kim Bak Jensen
Kim Jensen received his PhD in molecular biology from the University of Aarhus in 2003. Here, he developed an improved method for the analysis of the cell surface composition based on recombinant antibody technology. In 2003 he joined Professor Fiona Watt’s group at the London Research Institute, Cancer Research UK, as a post-doctoral fellow. Based on cutting edge technologies and analysis of mouse models he went on to identified Lrig1, a negative regulator of receptor tyrosine kinases, as a novel marker of both human and mouse epidermal stem cells. Since starting his own lab, research has focused on mechanisms that regulate stem cell fate during development, homeostasis, regeneration and disease.
Research in the Jensen lab currently aims to provide an increased understanding of the gene regulatory networks that control stem cell fate using the intestinal epithelium and the skin epidermis as model systems. By combining studies using mouse models and clinical specimens the long-term aim of the research in the Jensen lab is to translate result from in vitro and in vivo models into regenerative therapies.
Awards and Honours
Kim Jensen is a recipient of a number of personal awards including a Carlsberg and a CRUK postdoctoral fellowships, a Wellcome Trust Career Development Fellowship, an MRC non-clinical fellowship, a Lundbeck Foundation fellowship and the ERC consolidator award. In addition, he is the recipient of the European Society for Dermatological Research Gold medal and an EMBO Young Investigator, and serves on a number of scientific advisor boards.
Recent Key Discoveries
Guiu, J., Hannezo, E., Yui, S., Demharter, S., Ulyanchenko, S., Maimets, M., Jørgensen, A., Perlman, S., Lundvall, L., Mamsen, L.S., Larsen, A., Olesen, R.H., Andersen, C.Y., Thuesen, L.L., Hare, K.J., Pers, T.H., Khodosevich, K., Simons, B.D., Jensen, K.B. (2019). Tracing the origin of adult intestinal stem cells. Nature, doi: 10.1038/s41586-019-1212-5.
Andersen, M.S., Hannezo, E., Ulyanchenko, S., Estrach, S., Antoku, Y., Pisano, S., Boonekamp, K.E., Sendrup, S., Maimets, M., Pedersen M.T., Johansen, J.V., Clement, D.L., Feral, C.C., Simons, B.D., Jensen, K.B. (2019). Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states.Nature Cell Biology, doi: 10.1038/s41556-019-0362-x.
Moestrup, K.S., Chen, Y., Schepeler, T., Schweiger, P.J., and Jensen, K.B. (2018). Dietary control of skin lipid composition and microbiome. Journal of Investigative Dermatology 138,1225-1228, doi: 10.1016/j.jid.2017.12.005.
Yui, S., Azzolin, L., Maimets, M., Pedersen, M.T., Fordham, R.P., Hansen, S.L., Larsen, H.L., Guiu, J., Alves, M.R.P, Rundsten, C.F., Johansen, J.V., Li, Y., Madsen, C.D., Nakamura, T., Watanabe, M., Nielsen, O.H., Schweiger, P.J., Piccolo, S. and Jensen, K.B. (2017). YAP/TAZ-dependent reprogramming of colonic epithelium links ECM remodeling to tissue regeneration. Cell Stem Cell, 22, doi:10.1016/j.stem.2017.11.001.
Perea, D., Guiu, J., Hudry, B., Konstantinidou, C., Milona, A., Hadjieconomou, D., Carroll, T., Hoyer, N., Natarajan, D., Kallijärvi, J., Walker, J.A., Soba, P., Thapar, N., Cordero, J., Burns, A.J., Jensen, K.B. and Miguel-Aliaga, I. (2017). A new role for the Ret receptor tyrosine kinase in intestinal epithelia. EMBO J 36, 3029-3045, doi: 10.15252/embj.201696247.
Holmberg, F.E., Pedersen, J., Jørgensen, P., Soendergaard, C., Jensen, K.B. and Nielsen, O.H. (2017). Intestinal barrier integrity and inflammatory bowel disease: Stem cell-based approaches to regenerate the barrier. Journal of Tissue Engineering and Regenerative Medicine 12, 923 -935, doi: 10.1002/term.2506
Moestrup, K.S., Andersen, M.S. and Jensen, K.B. (2017). Isolation and in vitro characterization of epidermal stem cells. Methods Molecular Biology 1553, 67-83, doi: 10.1007/978-1-4939-6756-8_6.
Schweiger, P.J. and Jensen, K.B. (2016). Modeling human disease using organotypic cultures. Current Opinion in Cell Biology 43, 22-29, doi: 10.1016/j.ceb.2016.07.003
Guiu, J. and Jensen, K.B. (2015). From Definitive Endoderm to gut—a Process of Growth and Maturation. Stem Cells and Development 24, 1972-1983, doi: 10.1089/scd.2015.0017.
Schepeler, T., Page, M.E. and Jensen, K.B. (2014). Heterogeneity and plasticity of epidermal stem cells. Development 141, 2559-2567, doi: 10.1242/dev.104588.
Fordham, R.P., Yui, S., Hannan, N.R.F., Soendergaard, C., Madgwick, A., Schweiger, P.J., Nielsen, O.H., Vallier, L., Pedersen, R.A., Nakamura, T. Watanabe, M. and Jensen, K.B. (2013). Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell 13, 734-744, doi: 10.1016/j.stem.2013.09.015.
Hannan, N.R.F., Fordham, R.P., Syed, Y.A., Moignard, V., Berry, A., Bautista, R., Hanley, N.A, Jensen, K.B. and Vallier, L. (2013). Generation of Multipotent Foregut Stem Cells from Human Pluripotent Stem Cells. Stem Cell Reports 1, 293-306, doi: 10.1016/j.stemcr.2013.09.003.
Kim Bak Jensen