List of publications

Johnson, J. L., Stoica, L., Liu, Y., Zhu, P. J., Bhattacharya, A., Buffington, S., Huq, R., Eissa, N. T., Larsson, O., Porse, B. T., Domingo, D., Nawaz, U., Carroll, R., Jolly, L., Scerri, T. S., Kim, G. G., Brignell, A., Coleman, M. J., Braden, R., Kini, U., Jackson, V., Baxter, A., Bahlo, M., Scheffer, I. E., Amor, D. J., Hildebrand, M. S., Bonnen, P. E., Beeton, C., Gecz, J., Morgan, A. T. & Costa-Mattioli, M. (2019). Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response. Neuron, doi: 10.1016/j.neuron.2019.08.027

D'Altri, T., Schuster, M.B., Wenzel, A., Porse, B.T. (2019). Heterozygous loss of Srp72 in mice is not associated with major hematological phenotypes. European Journal of Haematology, doi: 10.1111/ejh.13286

Jakobsen, J.S., Laursen, L.G., Schuster, M.B., Pundhir, S., Schoof, E., Ge, Y., d’Altri, T., Vitting-Seerup, K., Rapin, N., Gentil, C., Jendholm, J., Theilgaard-Mönch, K., Reckzeh, K., Bullinger, L., Döhner, K., Hokland, P., Fitzgibbon, J., Porse, B.T. (2019) Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML. Science Advances, 5, eaaw4304, doi: 10.1126/sciadv.aaw4304.

Morgan, M., Kabayama, Y., Much, C., Ivanova, I., Di Giacomo, M., Auchynnikava, T., Monahan, J.M., Vitsios, D.M., Vasiliauskaitė, L., Comazzetto, S., Rappsilber, J., Allshire, R.C., Porse, B.T., Enright, A.J., and  O'Carroll, D. (2019). A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis. Cell Research, 1 -12, doi: 10.1038/s41422-018-0128-1

Ge, Y., Schuster, M.B., Pundhir, S., Rapin, N., Bagger, F.O., Sidiropoulos, N., Hashem, N., and Porse, B.T. (2019). The splicing factor RBM25 controls MYC activity in acute myeloid leukemia. Nature Communications 10, doi: 10.1038/s41467-018-08076-y.

Wilhelmson, A.S., Lantero Rodriguez, M., Stubelius, A., Fogelstrand, P., Johansson, I., Buechler, M.B., Lianoglou, S., Kapoor, V.N., Johansson, M.E., Fagman, J.B., Duhlin, A., Tripathi, P., Camponeschi, A., Porse, B.T., Rolink, A.G., Nissbrandt, H., Turley, S.J., Carlsten, H., Martensson, I.L., Karlsson, M.C.I., and Tivesten, A. (2018). Testosterone is an endogenous regulator of BAFF and splenic B cell number. Nature Communications 9, doi:10.1038/s41467-018-04408-0.

Pundhir, S., Bratt Lauridsen, F.K., Schuster, M.B., Jakobsen, J.S., Ge, Y., Schoof, E.M., Rapin, N., Waage, J., Hasemann, M.S., and Porse, B.T. (2018). Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors. Cell Rep 23, 2744-2757, doi:10.1016/j.celrep.2018.05.012.

Martin Gonzalez, J., Baudet, A., Abelechian, S., Bonderup, K., d'Altri, T., Porse, B., Brakebusch, C., Juliusson, G., and Cammenga, J. (2018). A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines. Genesis (New York, NY : 2000) 56, e23238, doi:10.1002/dvg.23238.

Lauridsen, F.K.B., Jensen, T.L., Rapin, N., Aslan, D., Wilhelmson, A.S., Pundhir, S., Rehn, M., Paul, F., Giladi, A., Hasemann, M.S., Serup, P., Amit, I., and Porse, B.T. (2018). Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment. Cell Reports 24, 766-780, doi:10.1016/j.celrep.2018.06.057.

Gu, X., Ebrahem, Q., Mahfouz, R.Z., Hasipek, M., Enane, F., Radivoyevitch, T., Rapin, N., Przychodzen, B., Hu, Z., Balusu, R., Cotta, C.V., Wald, D., Argueta, C., Landesman, Y., Martelli, M.P., Falini, B., Carraway, H., Porse, B.T., Maciejewski, J., Jha, B.K., and Saunthararajah, Y. (2018). Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates. The Journal of clinical investigation 128, 4260-4279, doi:10.1172/jci97117.

Reckzeh, K., Kizilkaya, H., Helbo, A.S., Alrich, M.E., Deslauriers, A.G., Grover, A., Rapin, N., Asmar, F., Gronbaek, K., Porse, B., Borregaard, N., Vestweber, D., Nerlov, C., and Theilgaard-Monch, K. (2018). Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin. Blood advances 2, 1628-1632, doi:10.1182/bloodadvances.2018015743.

Mohammad, F., Weissmann, S., Leblanc, B., Pandey, D.P., Hojfeldt, J.W., Comet, I., Zheng, C., Johansen, J.V., Rapin, N., Porse, B.T., Tvardovskiy, A., Jensen, O.N., Olaciregui, N.G., Lavarino, C., Sunol, M., de Torres, C., Mora, J., Carcaboso, A.M., and Helin, K. (2017). EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas. Nature Medicine 23, 483-492, doi:10.1038/nm.4293.

Paul, F., Arkin, Y., Giladi, A., Jaitin, D.A., Kenigsberg, E., Keren-Shaul, H., Winter, D., Lara-Astiaso, D., Gury, M., Weiner, A., David, E., Cohen, N., Lauridsen, F.K.B., Haas, S., Schlitzer, A., Mildner, A., Ginhoux, F., Jung, S., Trumpp, A., Porse, B.T., Tanay, A., and Amit, I. (2016). Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. Cell 164, 325, doi:10.1016/j.cell.2015.12.046.

O'Connor, C., Lohan, F., Campos, J., Ohlsson, E., Salome, M., Forde, C., Artschwager, R., Liskamp, R.M., Cahill, M.R., Kiely, P.A., Porse, B., and Keeshan, K. (2016). The presence of C/EBPalpha and its degradation are both required for TRIB2-mediated leukaemia. Oncogene 35, 5272-5281, doi:10.1038/onc.2016.66.

Ohlsson, E., Schuster, M.B., Hasemann, M., and Porse, B.T. (2016). The multifaceted functions of C/EBPalpha in normal and malignant haematopoiesis. Leukemia 30, 767-775, doi:10.1038/leu.2015.324.

Bagger, F.O., Sasivarevic, D., Sohi, S.H., Laursen, L.G., Pundhir, S., Sonderby, C.K., Winther, O., Rapin, N., and Porse, B.T. (2016). BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis. Nucleic Acids Research 44, D917-924, doi:10.1093/nar/gkv1101.

Di Stefano, B., Collombet, S., Jakobsen, J.S., Wierer, M., Sardina, J.L., Lackner, A., Stadhouders, R., Segura-Morales, C., Francesconi, M., Limone, F., Mann, M., Porse, B., Thieffry, D., and Graf, T. (2016). C/EBPalpha creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4. Nature Cell Biology 18, 371-381, doi:10.1038/ncb3326.

Bao, J., Vitting-Seerup, K., Waage, J., Tang, C., Ge, Y., Porse, B.T., and Yan, W. (2016). UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genetics 12, e1005863, doi:10.1371/journal.pgen.1005863.

Pundhir, S., Bagger, F.O., Lauridsen, F.B., Rapin, N., and Porse, B.T. (2016). Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality. Nucleic Acids Research 44, 4037-4051, doi:10.1093/nar/gkw250.

Xu, M.J., Feng, D., Wu, H., Wang, H., Chan, Y., Kolls, J., Borregaard, N., Porse, B., Berger, T., Mak, T.W., Cowland, J.B., Kong, X., and Gao, B. (2015). Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3. Hepatology 61, 692-702, doi:10.1002/hep.27447.

Willer, A., Jakobsen, J.S., Ohlsson, E., Rapin, N., Waage, J., Billing, M., Bullinger, L., Karlsson, S., and Porse, B.T. (2015). TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia. Leukemia 29, 1018-1031, doi:10.1038/leu.2014.307.

Jakobsen, J.S., Bagger, F.O., Hasemann, M.S., Schuster, M.B., Frank, A.K., Waage, J., Vitting-Seerup, K., and Porse, B.T. (2015). Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq. BMC Genomics 16, 46, doi:10.1186/s12864-014-1195-4.

Bao, J., Tang, C., Yuan, S., Porse, B.T., and Yan, W. (2015). UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome. Development 142, 352-362, doi:10.1242/dev.115642.

Knudsen, K.J., Rehn, M., Hasemann, M.S., Rapin, N., Bagger, F.O., Ohlsson, E., Willer, A., Frank, A.K., Sondergaard, E., Jendholm, J., Thoren, L., Lee, J., Rak, J., Theilgaard-Monch, K., and Porse, B.T. (2015). ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation. Genes and development 29, 1915-1929, doi:10.1101/gad.268409.115.

Mora-Jensen, H., Jendholm, J., Rapin, N., Andersen, M.K., Roug, A.S., Bagger, F.O., Bullinger, L., Winther, O., Borregaard, N., Porse, B.T., and Theilgaard-Monch, K. (2015). Cellular origin of prognostic chromosomal aberrations in AML patients. Leukemia 29, 1785-1789, doi:10.1038/leu.2015.30.

Paul, F., Arkin, Y., Giladi, A., Jaitin, D.A., Kenigsberg, E., Keren-Shaul, H., Winter, D., Lara-Astiaso, D., Gury, M., Weiner, A., David, E., Cohen, N., Lauridsen, F.K., Haas, S., Schlitzer, A., Mildner, A., Ginhoux, F., Jung, S., Trumpp, A., Porse, B.T., Tanay, A., and Amit, I. (2015). Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. Cell 163, 1663-1677, doi:10.1016/j.cell.2015.11.013.

Rasmussen, K.D., Jia, G., Johansen, J.V., Pedersen, M.T., Rapin, N., Bagger, F.O., Porse, B.T., Bernard, O.A., Christensen, J., and Helin, K. (2015). Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis. Genes and development 29, 910-922, doi:10.1101/gad.260174.115.

Tawana, K., Wang, J., Renneville, A., Bodor, C., Hills, R., Loveday, C., Savic, A., Van Delft, F.W., Treleaven, J., Georgiades, P., Uglow, E., Asou, N., Uike, N., Debeljak, M., Jazbec, J., Ancliff, P., Gale, R., Thomas, X., Mialou, V., Dohner, K., Bullinger, L., Mueller, B., Pabst, T., Stelljes, M., Schlegelberger, B., Wozniak, E., Iqbal, S., Okosun, J., Araf, S., Frank, A.K., Lauridsen, F.B., Porse, B., Nerlov, C., Owen, C., Dokal, I., Gribben, J., Smith, M., Preudhomme, C., Chelala, C., Cavenagh, J., and Fitzgibbon, J. (2015). Disease evolution and outcomes in familial AML with germline CEBPA mutations. Blood 126, 1214-1223, doi:10.1182/blood-2015-05-647172.

Rishi, L., Hannon, M., Salome, M., Hasemann, M., Frank, A.K., Campos, J., Timoney, J., O'Connor, C., Cahill, M.R., Porse, B., and Keeshan, K. (2014). Regulation of Trib2 by an E2F1-C/EBPalpha feedback loop in AML cell proliferation. Blood 123, 2389-2400, doi:10.1182/blood-2013-07-511683.

Rapin, N., Bagger, F.O., Jendholm, J., Mora-Jensen, H., Krogh, A., Kohlmann, A., Thiede, C., Borregaard, N., Bullinger, L., Winther, O., Theilgaard-Monch, K., and Porse, B.T. (2014). Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients. Blood 123, 894-904, doi:10.1182/blood-2013-02-485771.

Rapin, N., and Porse, B.T. (2014). Oncogenic fusion proteins expressed in immature hematopoietic cells fail to recapitulate the transcriptional changes observed in human AML. Oncogenesis 3, e106, doi:10.1038/oncsis.2014.22.

Ohlsson, E., Hasemann, M.S., Willer, A., Lauridsen, F.K., Rapin, N., Jendholm, J., and Porse, B.T. (2014). Initiation of MLL-rearranged AML is dependent on C/EBPalpha. The Journal of experimental medicine 211, 5-13, doi:10.1084/jem.20130932.

Norrie, I.C., Ohlsson, E., Nielsen, O., Hasemann, M.S., and Porse, B.T. (2014). C/EBPalpha is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner. PLoS One 9, e84728, doi:10.1371/journal.pone.0084728.

Ge, Y., and Porse, B.T. (2014). The functional consequences of intron retention: alternative splicing coupled to NMD as a regulator of gene expression. Bioessays 36, 236-243, doi:10.1002/bies.201300156.

Klein, H.U., Schafer, M., Porse, B.T., Hasemann, M.S., Ickstadt, K., and Dugas, M. (2014). Integrative analysis of histone ChIP-seq and transcription data using Bayesian mixture models. Bioinformatics 30, 1154-1162, doi:10.1093/bioinformatics/btu003.

Hasemann, M.S., Lauridsen, F.K., Waage, J., Jakobsen, J.S., Frank, A.K., Schuster, M.B., Rapin, N., Bagger, F.O., Hoppe, P.S., Schroeder, T., and Porse, B.T. (2014). C/EBPalpha is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors. PLoS Genet 10, e1004079, doi:10.1371/journal.pgen.1004079.

Sroczynska, P., Cruickshank, V.A., Bukowski, J.P., Miyagi, S., Bagger, F.O., Walfridsson, J., Schuster, M.B., Porse, B., and Helin, K. (2014). shRNA screening identifies JMJD1C as being required for leukemia maintenance. Blood 123, 1870-1882, doi:10.1182/blood-2013-08-522094.

Vitting-Seerup, K., Porse, B.T., Sandelin, A., and Waage, J. (2014). spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data. BMC Bioinformatics 15, 81, doi:10.1186/1471-2105-15-81.

Jakobsen, J.S., Waage, J., Rapin, N., Bisgaard, H.C., Larsen, F.S., and Porse, B.T. (2013). Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries. Genome Research 23, 592-603, doi:10.1101/gr.146399.112.

Colak, D., Ji, S.J., Porse, B.T., and Jaffrey, S.R. (2013). Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay. Cell 153, 1252-1265, doi:10.1016/j.cell.2013.04.056.

Bagger, F.O., Rapin, N., Theilgaard-Monch, K., Kaczkowski, B., Thoren, L.A., Jendholm, J., Winther, O., and Porse, B.T. (2013). HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis. Nucleic Acids Research 41, D1034-1039, doi:10.1093/nar/gks1021.

Leucci, E., Patella, F., Waage, J., Holmstrom, K., Lindow, M., Porse, B., Kauppinen, S., and Lund, A.H. (2013). microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus. Scientific Reports 3, 2535, doi:10.1038/srep02535.

Schuster, M.B., Frank, A.K., Bagger, F.O., Rapin, N., Vikesaa, J., and Porse, B.T. (2013). Lack of the p42 form of C/EBPalpha leads to spontaneous immortalization and lineage infidelity of committed myeloid progenitors. Experimental Hematology 41, 882-893.e816, doi:10.1016/j.exphem.2013.06.003.

Thoren, L.A., Fog, C.K., Jensen, K.T., Buza-Vidas, N., Come, C., Lund, A.H., and Porse, B.T. (2013). PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells. Stem Cell Research 11, 1129-1136, doi:10.1016/j.scr.2013.07.009.

Zheng, S., Gray, E.E., Chawla, G., Porse, B.T., O'Dell, T.J., and Black, D.L. (2012). PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2. Nature neuroscience 15, 381-388, s381, doi:10.1038/nn.3026.

Treppendahl, M.B., Qiu, X., Sogaard, A., Yang, X., Nandrup-Bus, C., Hother, C., Andersen, M.K., Kjeldsen, L., Mollgard, L., Hellstrom-Lindberg, E., Jendholm, J., Porse, B.T., Jones, P.A., Liang, G., and Gronbaek, K. (2012). Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML. Blood 119, 206-216, doi:10.1182/blood-2011-06-362541.

Hasemann, M.S., Schuster, M.B., Frank, A.K., Theilgaard-Monch, K., Pedersen, T.A., Nerlov, C., and Porse, B.T. (2012). Phosphorylation of serine 248 of C/EBPalpha is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency. PLoS One 7, e38841, doi:10.1371/journal.pone.0038841.

Adams, D., Altucci, L., Antonarakis, S.E., Ballesteros, J., Beck, S., Bird, A., Bock, C., Boehm, B., Campo, E., Caricasole, A., Dahl, F., Dermitzakis, E.T., Enver, T., Esteller, M., Estivill, X., Ferguson-Smith, A., Fitzgibbon, J., Flicek, P., Giehl, C., Graf, T., Grosveld, F., Guigo, R., Gut, I., Helin, K., Jarvius, J., Kuppers, R., Lehrach, H., Lengauer, T., Lernmark, A., Leslie, D., Loeffler, M., Macintyre, E., Mai, A., Martens, J.H., Minucci, S., Ouwehand, W.H., Pelicci, P.G., Pendeville, H., Porse, B., Rakyan, V., Reik, W., Schrappe, M., Schubeler, D., Seifert, M., Siebert, R., Simmons, D., Soranzo, N., Spicuglia, S., Stratton, M., Stunnenberg, H.G., Tanay, A., Torrents, D., Valencia, A., Vellenga, E., Vingron, M., Walter, J., and Willcocks, S. (2012). BLUEPRINT to decode the epigenetic signature written in blood. Nature biotechnology 30, 224-226, doi:10.1038/nbt.2153.

Bagger, F.O., Rapin, N., Theilgaard-Monch, K., Kaczkowski, B., Jendholm, J., Winther, O., and Porse, B. (2012). HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis. Blood 119, 6394-6395, doi:10.1182/blood-2012-05-427310.

Weischenfeldt, J., Waage, J., Tian, G., Zhao, J., Damgaard, I., Jakobsen, J.S., Kristiansen, K., Krogh, A., Wang, J., and Porse, B.T. (2012). Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns. Genome biology 13, R35, doi:10.1186/gb-2012-13-5-r35.

Theilgaard-Monch, K., Boultwood, J., Ferrari, S., Giannopoulos, K., Hernandez-Rivas, J.M., Kohlmann, A., Morgan, M., Porse, B., Tagliafico, E., Zwaan, C.M., Wainscoat, J., Van den Heuvel-Eibrink, M.M., Mills, K., and Bullinger, L. (2011). Gene expression profiling in MDS and AML: potential and future avenues. Leukemia 25, 909-920, doi:10.1038/leu.2011.48.

Mora-Jensen, H., Jendholm, J., Fossum, A., Porse, B., Borregaard, N., and Theilgaard-Monch, K. (2011). Technical advance: immunophenotypical characterization of human neutrophil differentiation. Journal of leukocyte biology 90, 629-634, doi:10.1189/jlb.0311123.

Wu, H., Santoni-Rugiu, E., Ralfkiaer, E., Porse, B.T., Moser, C., Hoiby, N., Borregaard, N., and Cowland, J.B. (2010). Lipocalin 2 is protective against E. coli pneumonia. Respiratory research 11, 96, doi:10.1186/1465-9921-11-96.

Pasini, D., Malatesta, M., Jung, H.R., Walfridsson, J., Willer, A., Olsson, L., Skotte, J., Wutz, A., Porse, B., Jensen, O.N., and Helin, K. (2010). Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes. Nucleic Acids Research 38, 4958-4969, doi:10.1093/nar/gkq244.

Porse, B. (2010). Leukemia - methods and protocols. European journal of haematology 84, 94, doi:10.1111/j.1600-0609.2009.01354.x.

Marstrand, T.T., Borup, R., Willer, A., Borregaard, N., Sandelin, A., Porse, B.T., and Theilgaard-Monch, K. (2010). A conceptual framework for the identification of candidate drugs and drug targets in acute promyelocytic leukemia. Leukemia 24, 1265-1275, doi:10.1038/leu.2010.95.

Porse, B.T., Petersen, O.W., and Helin, K. (2010). Basic stem cell biology and cancer. Ugeskrift for læger 172, 2600-2603.

Thoren, L.A., Norgaard, G.A., Weischenfeldt, J., Waage, J., Jakobsen, J.S., Damgaard, I., Bergstrom, F.C., Blom, A.M., Borup, R., Bisgaard, H.C., and Porse, B.T. (2010). UPF2 is a critical regulator of liver development, function and regeneration. PLoS One 5, e11650, doi:10.1371/journal.pone.0011650.

Schuster, M.B., and Porse, B.T. (2009). C/EBPalpha in leukemogenesis: identity and origin of the leukemia-initiating cell. BioFactors (Oxford, England) 35, 227-231, doi:10.1002/biof.36.

Weischenfeldt, J., and Porse, B. (2008). Bone Marrow-Derived Macrophages (BMM): Isolation and Applications. CSH protocols 2008, pdb.prot5080, doi:10.1101/pdb.prot5080.

Weischenfeldt, J., Damgaard, I., Bryder, D., Theilgaard-Monch, K., Thoren, L.A., Nielsen, F.C., Jacobsen, S.E., Nerlov, C., and Porse, B.T. (2008). NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes and development 22, 1381-1396, doi:10.1101/gad.468808.

Hasemann, M.S., Damgaard, I., Schuster, M.B., Theilgaard-Monch, K., Sorensen, A.B., Mrsic, A., Krugers, T., Ylstra, B., Pedersen, F.S., Nerlov, C., and Porse, B.T. (2008). Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen. Blood 111, 4309-4321, doi:10.1182/blood-2007-06-097790.

Christoffersen, C., Jauhiainen, M., Moser, M., Porse, B., Ehnholm, C., Boesl, M., Dahlback, B., and Nielsen, L.B. (2008). Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice. The Journal of biological chemistry 283, 1839-1847, doi:10.1074/jbc.M704576200.

Kirstetter, P., Schuster, M.B., Bereshchenko, O., Moore, S., Dvinge, H., Kurz, E., Theilgaard-Monch, K., Mansson, R., Pedersen, T.A., Pabst, T., Schrock, E., Porse, B.T., Jacobsen, S.E., Bertone, P., Tenen, D.G., and Nerlov, C. (2008). Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Cancer Cell 13, 299-310, doi:10.1016/j.ccr.2008.02.008.

Weischenfeldt, J., and Porse, B. (2008). Bone Marrow-Derived Macrophages (BMM): Isolation and Applications. CSH protocols 2008, pdb.prot5080, doi:10.1101/pdb.prot5080.

Bracken, A.P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Monch, K., Minucci, S., Porse, B.T., Marine, J.C., Hansen, K.H., and Helin, K. (2007). The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes and development 21, 525-530, doi:10.1101/gad.415507.

Pedersen, T.A., Bereshchenko, O., Garcia-Silva, S., Ermakova, O., Kurz, E., Mandrup, S., Porse, B.T., and Nerlov, C. (2007). Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. The EMBO journal 26, 1081-1093, doi:10.1038/sj.emboj.7601563.

Theilgaard-Monch, K., Jacobsen, L.C., Nielsen, M.J., Rasmussen, T., Udby, L., Gharib, M., Arkwright, P.D., Gombart, A.F., Calafat, J., Moestrup, S.K., Porse, B.T., and Borregaard, N. (2006a). Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation. Blood 108, 353-361, doi:10.1182/blood-2005-09-3890.

Theilgaard-Monch, K., Porse, B.T., and Borregaard, N. (2006b). Systems biology of neutrophil differentiation and immune response. Current opinion in immunology 18, 54-60, doi:10.1016/j.coi.2005.11.010.

Porse, B.T., Pedersen, T.A., Hasemann, M.S., Schuster, M.B., Kirstetter, P., Luedde, T., Damgaard, I., Kurz, E., Schjerling, C.K., and Nerlov, C. (2006). The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo. Molecular Cell Biolology 26, 1028-1037, doi:10.1128/mcb.26.3.1028-1037.2006.

Kirstetter, P., Anderson, K., Porse, B.T., Jacobsen, S.E., and Nerlov, C. (2006). Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol 7, 1048-1056, doi:10.1038/ni1381.

Schuster, M.B., and Porse, B.T. (2006). C/EBPalpha: a tumour suppressor in multiple tissues?. Biochimica et Biophysica Acta 1766, 88-103, doi:10.1016/j.bbcan.2006.02.003.

Weischenfeldt, J., Lykke-Andersen, J., and Porse, B. (2005). Messenger RNA surveillance: neutralizing natural nonsense. Current biology : CB 15, R559-562, doi:10.1016/j.cub.2005.07.002.

Theilgaard-Monch, K., Jacobsen, L.C., Rasmussen, T., Niemann, C.U., Udby, L., Borup, R., Gharib, M., Arkwright, P.D., Gombart, A.F., Calafat, J., Porse, B.T., and Borregaard, N. (2005). Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils. Journal of leukocyte biology 78, 462-470, doi:10.1189/jlb.0105042.

Porse, B.T., Bryder, D., Theilgaard-Monch, K., Hasemann, M.S., Anderson, K., Damgaard, I., Jacobsen, S.E., and Nerlov, C. (2005). Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage. The Journal of experimental medicine 202, 85-96, doi:10.1084/jem.20050067.

Andersen, T.E., Porse, B.T., and Kirpekar, F. (2004). A novel partial modification at C2501 in Escherichia coli 23S ribosomal RNA. RNA (New York, NY) 10, 907-913, doi: 10.1261/rna.5259404

Long, K.S., and Porse, B.T. (2003). A conserved chloramphenicol binding site at the entrance to the ribosomal peptide exit tunnel. Nucleic Acids Res 31, 7208-7215, doi:10.1093/nar/gkg945

Schuster, M.B., and Porse, B.T. (2003). Transgenic mice as disease models. Ugeskrift for laeger 165, 793-796.

Porse, B.T., Pedersen, T.A., Xu, X., Lindberg, B., Wewer, U.M., Friis-Hansen, L., and Nerlov, C. (2001). E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Cell 107, 247-258, doi: 10.1016/S0092-8674(01)00516-5.

Rodriguez-Fonseca, C., Phan, H., Long, K.S., Porse, B.T., Kirillov, S.V., Amils, R., and Garrett, R.A. (2000). Puromycin-rRNA interaction sites at the peptidyl transferase center. RNA (New York, NY) 6, 744-754.

Porse, B.T., Cundliffe, E., and Garrett, R.A. (1999a) The antibiotic micrococcin acts on protein L11 at the ribosomal GTPase centre. Journal of molecular biology 287, 33-45, doi:10.1006/jmbi.1999.2600.

Kirillov, S.V., Porse, B.T., and Garrett, R.A. (1999). Peptidyl transferase antibiotics perturb the relative positioning of the 3'-terminal adenosine of P/P'-site-bound tRNA and 23S rRNA in the ribosome. RNA (New York, NY) 5, 1003-1013.

Porse, B.T., and Garrett, R.A. (1999a). Ribosomal mechanics, antibiotics, and GTP hydrolysis. Cell 97, 423-426, doi:10.1016/S0092-8674(00)80751-5.

Porse, B.T., and Garrett, R.A. (1999b). Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms. Journal of molecular biology 286, 375-387, doi:10.1006/jmbi.1998.2509.

Porse, B.T., Kirillov, S.V., Awayez, M.J., and Garrett, R.A. (1999b). UV-induced modifications in the peptidyl transferase loop of 23S rRNA dependent on binding of the streptogramin B antibiotic, pristinamycin IA. RNA (New York, NY) 5, 585-595.

Porse, B.T., Kirillov, S.V., Awayez, M.J., Ottenheijm, H.C., and Garrett, R.A. (1999c). Direct crosslinking of the antitumor antibiotic sparsomycin, and its derivatives, to A2602 in the peptidyl transferase center of 23S-like rRNA within ribosome-tRNA complexes. Proceedings of the National Academy of Sciences USA 96, 9003-9008, doi:10.1073/pnas.96.16.9003.

Porse, B.T., Leviev, I., Mankin, A.S., and Garrett, R.A. (1998). The antibiotic thiostrepton inhibits a functional transition within protein L11 at the ribosomal GTPase centre. Journal of molecular biology 276, 391-404, doi:10.1006/jmbi.1997.1541.

Ostergaard, P., Phan, H., Johansen, L.B., Egebjerg, J., Ostergaard, L., Porse, B.T., and Garrett, R.A. (1998). Assembly of proteins and 5 S rRNA to transcripts of the major structural domains of 23 S rRNA. Journal of molecular biology 284, 227-240, doi:10.1006/jmbi.1998.2185.

Kirillov, S., Porse, B.T., Vester, B., Woolley, P., and Garrett, R.A. (1997). Movement of the 3'-end of tRNA through the peptidyl transferase centre and its inhibition by antibiotics. FEBS letters 406, 223-233, doi:10.1016/S0014-5793(97)00261-5

Porse, B.T., Thi-Ngoc, H.P., and Garrett, R.A. (1996). The donor substrate site within the peptidyl transferase loop of 23 S rRNA and its putative interactions with the CCA-end of N-blocked aminoacyl-tRNA(Phe). Journal of molecular biology 264, 472-483, doi:10.1006/jmbi.1996.0655.

Lazaro, E., Rodriguez-Fonseca, C., Porse, B., Urena, D., Garrett, R.A., and Ballesta, J.P. (1996). A sparsomycin-resistant mutant of Halobacterium salinarium lacks a modification at nucleotide U2603 in the peptidyl transferase centre of 23 S rRNA. Journal of molecular biology 261, 231-238, doi:10.1006/jmbi.1996.0455.

Porse, B.T., and Garrett, R.A. (1995). Mapping important nucleotides in the peptidyl transferase centre of 23 S rRNA using a random mutagenesis approach. Journal of molecular biology 249, 1-10, doi:10.1006/jmbi.1995.0276.

Porse, B.T., Rodriguez-Fonseca, C., Leviev, I., and Garrett, R.A. (1995). Antibiotic inhibition of the movement of tRNA substrates through a peptidyl transferase cavity. Biochemistry and cell biology = Biochimie et biologie cellulaire 73, 877-885, doi:10.1139/o95-095.