Human Stem Cells in Organ Formation and as a Source for Cellular Therapy
The Semb group has two main goals 1) to understand the connection between epithelial architecture and the commitment of pancreatic progenitor cells to mature endocrine cells and vice versa, and 2) to translate this knowledge into efficient and reliable strategies for regenerative medicine in diabetes. These objectives are applied, primarily, to their organ of choice – the pancreas. The Semb group uses a combination of mouse pancreatic epithelium and human stem cells as model systems to explore their goals, which, in turn, also serve as tools to understand pancreatic disease. Functioning as an interdisciplinary lab they work to combine knowledge from multiple systems; through the combinatorial use of animal models, stem cells and computer modelling the group is exceptionally well placed to attain their goals.