List of publication

Nyeng, P., Heilmann, S., Löf-Öhlin, Z.M., Pettersson, N.F., Hermann, F.M., Reynolds, A.B., Semb, H. (2019). p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate. Developmental Cell, 49, 1-17, doi: 10.1016/j.devcel.2019.02.005.

Mamidi, A., Prawiro, C., Seymour, P.A., de Lichtenberg, K.H., Jackson, A., Serup, P., and Semb, H. (2018). Mechanosignalling via integrins directs fate decisions of pancreatic progenitorsNature, doi: 10.1038/s41586-018-0762-2

Löf-Öhlin, Z.M., Nyeng, P., Bechard, M.E., Hess, K., Bankaitis, E., Greiner, T.U., Ameri, J., Wright, C.V. and Semb H. (2017). EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity. Nature Cell Biology 19, 1313-1325, doi:10.1038/ncb3628. Erratum in: Nature Cell Biology 19, 1442, doi:10.1038/ncb3646.

Ramond, C., Glaser, N., Berthault, C., Ameri, J., Kirkegaard, J.S., Hansson, M., Honoré, C., Semb, H. and Scharfmann, R. (2017). Reconstructing human pancreatic differentiation by mapping specific cell populations during development. Elife 6, pii: e27564. doi:10.7554/eLife.27564.

Ameri, J., Borup, R., Prawiro, C., Ramond, C., Schachter, K.A., Scharfmann, R. and Semb, H. (2017). Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors. Cell Reports 19, 36-49. doi:10.1016/j.celrep.2017.03.032.

Arregi, I., Climent, M., Iliev, D., Strasser, J., Gouignard, N., Johansson, J.K., Singh, T., Mazur, M., Semb, H., Artner, I., Minichiello, L. and Pera, E.M. (2016). Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling. Endocrinology 157, 4615-4631, doi:10.1210/en.2016-1745.

Funa, N.S., Schachter, K.A., Lerdrup, M., Ekberg, J., Hess, K., Dietrich, N., Honore, C., Hansen, K. and Semb, H. (2015). beta-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4. Cell Stem Cell 16, 639-652, doi:10.1016/j.stem.2015.03.008.

Kesavan, G., Lieven, O., Mamidi, A., Öhlin, Z.L., Johansson, J.K., Li, W.-C., Lommel, S., Greiner, T.U. and Semb, H. (2014). Cdc42/N-WASP signaling links actin dynamics to pancreatic beta cell delamination and differentiation. Development 141, 685-696, doi:10.1242/dev.100297.

Norrman, K., Strömbeck, A., Semb, H. and Ståhlberg, A. (2013). Distinct gene expression signatures in human embryonic stem cells differentiated towards definitive endoderm at single-cell level. Methods 59, 59-70, doi:10.1016/j.ymeth.2012.03.030.

Hernebring, M., Fredriksson, A., Liljevald, M., Cvijovic, M., Norrman, K., Wiseman, J., Semb, H. and Nyström, T. (2013). Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28. Scientific Reports 3, doi:10.1038/srep01381.

Greggio, C., De Franceschi, F., Figueiredo-Larsen, M., Gobaa, S., Ranga, A., Semb, H., Lutolf, M. and Grapin-Botton, A. (2013). Artificial three-dimensional niches deconstruct pancreas development in vitro. Development 140, 4452-4462, doi:10.1242/dev.096628.

Sand, F. W., Hornblad, A., Johansson, J. K., Loren, C., Edsbagge, J., Ståhlberg, A., Magenheim, J., Ilovich, O., Mishani, E., Dor, Y., Ahlgren, U. and Semb, H. (2011). Growth-limiting role of endothelial cells in endoderm development. Developmental Biology 352, 267-277, doi:10.1016/j.ydbio.2011.01.026.

Håkansson, J., Ståhlberg, A., Wolfhagen Sand, F., Gerhardt, H. and Semb, H. (2011). N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy. PLoS One 6, e26026, doi:10.1371/journal.pone.0026026.

Olivecrona, G., Ehrenborg, E., Semb, H., Makoveichuk, E., Lindberg, A., Hayden, M. R., Gin, P., Davies, B. S. J., Weinstein, M.M., Fong, L.G., Beigneux, A.P., Young, S.G., Olivecrona, T. and Hernell, O. (2010). Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. Journal of Lipid Research 51, 1535-1545, doi:10.1194/jlr.M002717.

Norrman, K., Fischer, Y., Bonnamy, B., Wolfhagen Sand, F., Ravassard, P. and Semb, H. (2010). Quantitative comparison of constitutive promoters in human ES cells. PLoS One 5, e12413, doi:10.1371/journal.pone.0012413.

Johansson, J. K., Voss, U., Kesavan, G., Kostetskii, I., Wierup, N., Radice, G. L. and Semb, H. (2010). N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover. Genesis (New York, N.Y. : 2000) 48, 374-381, doi:10.1002/dvg.20628.

Fischer, Y., Ganic, E., Ameri, J., Xian, X., Johannesson, M. and Semb, H. (2010). NANOG reporter cell lines generated by gene targeting in human embryonic stem cells. PLoS One 5, doi:10.1371/journal.pone.0012533.

Englund, M. C., Caisander, G., Noaksson, K., Emanuelsson, K., Lundin, K., Bergh, C., Hansson, C., Semb, H., Strehl, R. and Hyllner, J. (2010). The establishment of 20 different human embryonic stem cell lines and subclones; a report on derivation, culture, characterisation and banking. In vitro cellular & developmental biology. Animal 46, 217-230, doi:10.1007/s11626-010-9289-z.

Brolén, G., Sivertsson, L., Björquist, P., Eriksson, G., Ek, M., Semb, H., Johansson, I., Andersson, T.B., Ingelman-Sundberg, M. and Heins, N. (2010). Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage. Journal for Biotechnology 145, 284-294, doi:10.1016/j.jbiotec.2009.11.007.

Ameri, J., Ståhlberg, A., Pedersen, J., Johansson, J. K., Johannesson, M. M., Artner, I. and Semb, H. (2010). FGF2 specifies hESC-derived definitive endoderm into foregut/midgut cell lineages in a concentration-dependent manner. Stem Cells 28, 45-56, doi:10.1002/stem.249.

Ståhlberg, A., Bengtsson, M., Hemberg, M. and Semb, H. (2009). Quantitative Transcription Factor Analysis of Undifferentiated Single Human Embryonic Stem Cells. Clinical Chemistry 55, 2162-2170, doi:10.1373/clinchem.2009.131433.

Olofsson, C. S., Håkansson, J., Salehi, A., Bengtsson, M., Galvanovskis, J., Partridge, C., Soerhedewinzell, M., Xian, X., Eliasson, L., Lundquist, I., Semb, H. and Rorsman, P. (2009). Impaired Insulin Exocytosis in Neural Cell Adhesion Molecule(-/-) Mice Due to Defective Reorganization of the Submembrane F-Actin Network. Endocrinology 150, 3067-3075, doi:10.1210/en.2008-0475.

Kesavan, G., Sand, F. W., Greiner, T. U., Johansson, J. K., Kobberup, S., Wu, X., Brakebusch, C. and Semb, H. (2009). Cdc42-mediated tubulogenesis controls cell specification. Cell 139, 791-801, doi:10.1016/j.cell.2009.08.049.

Johannesson, M., Ståhlberg, A., Ameri, J., Sand, F. W., Norrman, K. and Semb, H. (2009). FGF4 and Retinoic Acid Direct Differentiation of hESCs into PDX1-Expressing Foregut Endoderm in a Time- and Concentration-Dependent Manner. Plos One 4, doi:10.1371/journal.pone.0004794.

Greiner, T. U., Kesavan, G., Ståhlberg, A. and Semb, H. (2009). Rac1 regulates pancreatic islet morphogenesis. BMC developmental biology 92, doi:10.1186/1471-213x-9-2.

Semb, H. (2008). Definitive endoderm: a key step in coaxing human embryonic stem cells into transplantable beta-cells. Biochemical Society Transactions 36272-275, doi:10.1042/bst0360272.

Semb, H. (2008). Expandable Endodermal Progenitors: New Tools to Explore Endoderm and Its Derivatives. Cell Stem Cell 3, 355-356, doi:10.1016/j.stem.2008.09.010.

Gerhardt, H. and Semb, H. (2008). Pericytes: gatekeepers in tumour cell metastasis? Journal of Molecular Medicine-Jmm 86(2), 135-144, doi:10.1007/s00109-007-0258-2.

Andersson, M. K., Ståhlberg, A., Arvidsson, Y., Olofsson, A., Semb, H., Stenman, G., Nilsson, O. and Aman, P. (2008). The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response. BMC Cell Biology 9, doi:10.1186/1471-2121-9-37.

Herzig, M., Savarese, F., Novatchkova, M., Semb, H. and Christofori, G. (2007). Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling. Oncogene 26, 2290-2298, doi:10.1038/sj.onc.1210029.

Ellerström, C., Strehl, R., Noaksson, K., Hyllner, J. and Semb, H. (2007). Facilitated expansion of human embryonic stem cells by single-cell enzymatic dissociation. Stem Cells 25(7), 1690-1696, doi:10.1634/stemcells.2006-0607.

Adewumi, O., Aflatoonian, B., Ahrlund-Richter, L., Amit, M., Andrews, P.W., Beighton, G., Bello, P.A., Benvenisty, N., Berry, L. S., Bevan, S., Blum, B., Brooking, J., Chen, K. G., Choo, A.B.H., Churchill, G.A., Corbel, M., Damjanov, I., Draper, J. S., Dvorak, P., Emanuelsson, K., Fleck, R.A., Ford, A., Gertow, K., Gertsenstein, M., Gokhale, P.J., Hamilton, R. S., Hampl, A., Healy, L.E., Hovatta, O., Hyllner, J., Imreh, M. P., Itskovitz-Eldor, J., Jackson, J., Johnson, J.L., Jones, M., Kee, K., King, B.L., Knowles, B.B., Lako, M., Lebrin, F., Mallon, B.S., Manning, D., Mayshar, Y., McKay, R.D.G., Michalska, A.E., Mikkola, M., Mileikovsky, M., Minger, S.L., Moore, H.D., Mummery, C.L., Nagy, A., Nakatsuji, N., O'Brien, C.M., Oh, S. K. W., Olsson, C., Otonkoski, T., Park, K.-Y., Passier, R., Patel, H., Patel, M., Pedersen, R., Pera, M.F., Piekarczyk, M.S., Pera, R.A.R., Reubinoff, B.E., Robins, A.J., Rossant, J., Rugg-Gunn, P., Schulz, T.C., Semb, H., Sherrer, E.S., Siemen, H., Stacey, G.N., Stojkovic, M., Suemori, H., Szatkiewicz, J., Turetsky, T., Tuuri, T., van den Brink, S., Vintersten, K., Vuoristo, S., Ward, D., Weaver, T. A., Young, L. A., Zhang, W. and Int Stem Cell, I. (2007). Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nature biotechnology 25, 803-816, doi:10.1038/nbt1318.

Xian, X. J., Håkansson, J., Ståhlberg, A., Lindblom, P., Betsholtz, C., Gerhardt, H. and Semb, H. (2006). Pericytes limit tumor cell metastasis. Journal of Clinical Investigation 116, 642-651, doi:10.1172/jci25705.

Hernebring, M., Brolén, G., Aguilaniu, H., Semb, H. and Nyström, T. (2006). Elimination of damaged proteins during differentiation of embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America 103(20), 7700-7705, doi:10.1073/pnas.0510944103.

Heins, N., Lindahl, A., Karlsson, U., Rehnström, M., Caisander, G., Emanuelsson, K., Hanson, C., Semb, H., Björquist, P., Sartipy, P. and Hyllner, J. (2006). Clonal derivation and characterization of human embryonic stem cell lines. Journal of Biotechnology 122(4), 511-520, doi:10.1016/j.jbiotec.2005.10.010.

Ellerström, C., Strehl, R., Moya, K., Andersson, K., Bergh, C., Lundin, K., Hyllner, J. and Semb, H. (2006). Derivation of a xeno-free human embryonic stem cell line. Stem Cells 24(10), 2170-2176, doi:10.1634/stemcells.2006-0130.

Semb, H. (2005). Human embryonic stem cells: origin, properties and applications. APMIS 113, 743-750, doi:10.1111/j.1600-0463.2005.apm_312.x.

Noaksson, K., Zoric, N., Zeng, X.M., Rao, M.S., Hyllner, J., Semb, H., Kubista, M. and Sartipy, P. (2005). Monitoring differentiation of human embryonic stem cells using real-time PCR. Stem Cells 23, 1460-1467, doi:10.1634/stemcells.2005-0093.

Håkansson, J., Xian, X. J., He, L.Q., Ståhlberg, A., Nelander, S., Samuelsson, T., Kubista, M. and Semb, H. (2005). Neural cell adhesion molecule-deficient beta-cell tumorigenesis results in diminished extracellular matrix molecule expression and tumour cell-matrix adhesion. Tumor Biology 26, 103-112, doi:10.1159/000085817.

Edsbagge, J., Johansson, J. K., Esni, F., Luo, Y., Radice, G. L. and Semb, H. (2005). Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development 132, 1085-1092, doi:10.1242/dev.01643.

Brolén, G.K.C., Heins, N., Edsbagge, J. and Semb, H. (2005). Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells. Diabetes 54, 2867-2874, doi:10.2337/diabetes.54.10.2867.

Andrews, P. W., Benvenisty, N., McKay, R., Pera, M. F., Rossant, J., Semb, H., Stacey, G.N. and Steering Comm Int Stem Cell, I. (2005). The International Stem Cell initiative: toward benchmarks for human embryonic stem cell research. Nature Biotechnology 23, 795-797, doi:10.1038/nbt0705-798.

Ståhlberg, A., Håkansson, J., Xian, X.J., Semb, H. and Kubista, M. (2004). Properties of the reverse transcription reaction in mRNA quantification. Clinical Chemistry 50, 509-515, doi:10.1373/clinchem.2003.026161.

Sjögren, A., Hardarson, T., Andersson, K., Caisander, G., Lundquist, M., Wikland, M., Semb, H. and Hamberger, L. (2004). Human blastocysts for the development of embryonic stem cells. Reproductive Biomedicine Online 9, 326-329.

Semb, H. (2004). Cadherins in development. Handbook of experimental pharmacology 165, 53-68, doi:10.1007/978-3-540-68170-0_3.

Heins, N., Englund, M. C. O., Sjöblom, C., Dahl, U., Tonning, A., Bergh, C., Lindahl, A., Hanson, C. and Semb, H. (2004). Derivation, characterization, and differentiation of human embryonic stem cells. Stem Cells 22, 367-376, doi:10.1634/stemcells.22-3-367.

Hansson, M., Tonning, A., Frandsen, U., Petri, A., Rajagopal, J., England, M.C.O., Heller, R.S., Håkansson, J., Fleckner, J., Skold, H.N., Melton, D., Semb, H. and Serup, P. (2004). Artifactual insulin release from differentiated embryonic stem cells. Diabetes 53, 2603-2609, doi:10.2337/diabetes.53.10.2603.

Edsbagge, J., Zhu, S. W., Xiao, M. Y., Wigström, H., Mohammed, A. H. and Semb, H. (2004). Expression of dominant negative cadherin in the adult mouse brain modifies rearing behavior. Molecular and Cellular Neuroscience 25, 524-535, doi:10.1016/j.mcn.2003.12.005.

Fagman, H., Grande, M., Edsbagge, J., Semb, H. and Nilsson, M. (2003). Expression of classical cadherins in thyroid development: Maintenance of an epithelial phenotype throughout organogenesis. Endocrinology 144, 3618-3624, doi:10.1210/en.2003-0393.

Dahl, U., Sjödin, A., Larue, L., Radice, G.L., Cajander, S., Takeichi, M., Kemler, R. and Semb, H. (2002). Genetic dissection of cadherin function during nephrogenesis. Molecular and Cellular Biology 22, 1474-1487, doi:10.1128/mcb.22.5.1474-1487.2002.

Esni, F., Johansson, B. R., Radice, G. L. and Semb, H. (2001). Dorsal pancreas agenesis in N-cadherin-deficient mice. Developmental Biology 238, 202-212, doi:10.1006/dbio.2001.0405.

Perl, A. K., Dahl, U., Wilgenbus, P., Cremer, H., Semb, H. and Christofori, G. (1999). Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Nature Medicine 5, 286-291, doi:1038/6502.

Larsson, M., Semb, H., Winblad, B., Amberla, K., Wahlund, L.O. and Backman, L. (1999). Odor identification in normal aging and early Alzheimer's disease: Effects of retrieval support. Neuropsychology 13, 47-53, doi:10.1037/0894-4105.13.1.47.

Esni, F., Taljedal, I.B., Perl, A.K., Cremer, H., Christofori, G. and Semb, H. (1999). Neural cell adhesion molecule (N-CAM) is required for cell type segregation and normal ultrastructure in pancreatic islets. Journal of Cell Biology 144, 325-337, doi:10.1083/jcb.144.2.325.

Christofori, G. and Semb, H. (1999). The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends in Biochemical Sciences 24, 73-76, doi:10.1016/s0968-0004(98)01343-7.

Semb, H. and Christofori, G. (1998). The tumor-suppressor function of E-cadherin. American Journal of Human Genetics 63, 1588-1593, doi:10.1086/302173.

Perl, A. K., Wilgenbus, P., Dahl, U., Semb, H. and Christofori, G. (1998). A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392, 190-193, doi:1038/32433.

Rosenberg, P., Esni, F., Sjödin, A., Larue, L., Carlsson, L., Gullberg, D., Takeichi, M., Kemler, R. and Semb, H. (1997). A potential role of R-cadherin in striated muscle formation. Developmental Biology 187, 55-70, doi:10.1006/dbio.1997.8602.

Eng, H., Herrenknecht, K., Semb, H., StarzinskiPowitz, A., Ringertz, N. and Gullberg, D. (1997). Effects of divalent cations on M-cadherin expression and distribution during primary rat myogenesis in vitro. Differentiation 61, 169-176, doi:10.1046/j.1432-0436.1997.6130169.x.

Dahl, U., Sjödin, A. and Semb, H. (1996). Cadherins regulate aggregation of pancreatic beta-cells in vivo. Development 122, 2895-2902.

Sjödin, A., Dahl, U. and Semb, H. (1995). Mouse R-cadherin - Expression during the organogenesis of pancreas and gastrointestinal-tract. Experimental Cell Research 221, 413-425, doi:10.1006/excr.1995.1392.

Fager, G., Semb, H., Enerback, S., Olivecrona, T., Jonasson, L., Bengtssonolivecrona, G., Camejo, G., Bjursell, G. and Bondjers, G. (1990). Hyperlipoproteinemia type-I in a patient with active lipoprotein-lipase in adipose-tissue and indications of defective transport of the enzyme. Journal of Lipid Research 31, 1187-1197.

Semb, H. and Olivecrona, T. (1989). The relation between glycolation and activity of guinea-pig lipoprotein-lipase. Journal of Biological Chemistry 264, 4195-4200.

Semb, H. and Olivecrona, T. (1989). 2 different mechanisms are involved in nutritional regulation of lipoprotein-lipose in guinea-pig adipose tissue. Biochemical Journal 262, 505-511.

Enerback, S., Semb, H., Tavernier, J., Bjursell, G. and Olivecrona, T. (1988). Tissue-specific regulation of guinea-pig lipoprotein-lipase - Effects of nutritional state and of tumor necrosis factor on messenger-RNA levels in adipose-tissue, heart and liver. Gene 64, 97-106, doi:10.1016/0378-1119(88)90484-2.

Semb, H., Peterson, J., Tavernier, J. and Olivecrona, T. (1987). Multiple effects of tumor-necrosis-factor on lipoprotein-lipase invivo. Immunobiology 175, 137-137.

Semb, H. and Olivecrona, T. (1987). Mechisms for turnover of lipoprotein-lipase in guinea-pig adipocytes. Biochimica Et Biophysica Acta 921, 104-115, doi:10.1016/0005-2760(87)90176-7.

Olivecrona, T. and Semb, H. (1987). Regulation of lipoprotein-lipase activity in guinea-pig adipose-tissue. International Journal of Obesity 1172, 72.

Olivecrona, T., Price, S. R., Pekala, P. H., Scow, R. O., Chernick, S. S., Semb, H., Vilaro, S. and Bengtsson-Olivecrona, G. Regulation of lipoprotein lipase activity its role in lipid-lowering therapies (1987).

Enerback, S., Semb, H., Bengtsson-Olivecrona, G., Carlsson, P., Hermansson, M. L., Olivecrona, T. and Bjursell, G. (1987). Molecular-cloning and sequence-analysis of cDNA-encoding lipoprotein-lipase of guinea-pig. Gene 58, 1-12, doi:10.1016/0378-1119(87)90023-0.

Semb, H. and Olivercrona, T. (1986). Lipoprotein-lipase in Guinea-pig tissues - Molecular-size and rates of synthesis. Biochimica Et Biophysica Acta 878(3), 330-337, doi:10.1016/0005-2760(86)90240-7.

Semb, H. and Olivecrona, T. (1986). Nutritional regulation of lipoprotein-lipase in guinea-pig tissues. Biochimica Et Biophysica Acta 876, 249-255, doi:10.1016/0005-2760(86)90281-x.