Developmental Biology of The Pancreas

Serup Group

The Serup group investigates how cell-cell signaling interfaces with lineage-specific transcription factors to regulate cell fate decisions. The group main focus is on how Notch signaling controls progenitor behaviour and differentiation in the developing pancreas. They explore the generality of their findings in other organ systems. They uncover novel principles in the gene regulatory network architecture and how ultradian oscillations in gene activity are linked to cell fate choice.