List of publications

Seymour, P. A., Collin, C. A., Egeskov-Madsen, A. la R., Jørgensen, M. C., Shimojo, H., Imayoshi, I., de Lichtenberg, K. H., Kopan, R., Kageyama, R., and Serup, P. (2020). Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Developmental Cell. doi: 10.1016/j.devcel.2020.01.015

Mamidi, A., Prawiro, C., Seymour, P.A., de Lichtenberg, K.H., Jackson, A., Serup, P., and Semb, H. (2018). Mechanosignalling via integrins directs fate decisions of pancreatic progenitorsNature, doi: 10.1038/s41586-018-0762-2

Lauridsen, F.K.B., Jensen, T.L., Rapin, N., Aslan, D., Wilhelmson, A.S., Pundhir, S., Rehn, M., Paul, F., Giladi, A., Hasemann, M.S., Serup, P., Amit, I., and Porse, B.T. (2018). Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment. Cell Reports 24, 766-780, doi:10.1016/j.celrep.2018.06.057.

Jorgensen, M.C., de Lichtenberg, K.H., Collin, C.A., Klinck, R., Ekberg, J.H., Engelstoft, M.S., Lickert, H., and Serup, P. (2018). Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice. Development 145, doi:10.1242/dev.163568.

Seymour, P.A., and Serup, P. (2018). Mesodermal induction of pancreatic fate commitment. Seminars in Cell and Developmental Biology, doi:10.1016/j.semcdb.2018.08.008.

Liu, K.C., Leuckx, G., Sakano, D., Seymour, P.A., Mattsson, C.L., Rautio, L., Staels, W., Verdonck, Y., Serup, P., Kume, S., Heimberg, H., and Andersson, O. (2018). Inhibition of Cdk5 Promotes beta-Cell Differentiation From Ductal Progenitors. Diabetes 67, 58-70, doi:10.2337/db16-1587.

Turner, D.A., Girgin, M., Alonso-Crisostomo, L., Trivedi, V., Baillie-Johnson, P., Glodowski, C.R., Hayward, P.C., Collignon, J., Gustavsen, C., Serup, P., Steventon, B., M, P.L., and Arias, A.M. (2017). Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids. Development 144, 3894-3906, doi:10.1242/dev.150391.

Grapin-Botton, A., and Serup, P. (2017). Parsing the Pancreas. New England Journal of Medicine 376, 886-888, doi:10.1056/NEJMcibr1616217.

Brickman, J.M., and Serup, P. (2017). Properties of embryoid bodies. Wiley Interdisciplinary Reviews Developmental Biology 6, doi:10.1002/wdev.259.

Stasiulewicz, M., Gray, S.D., Mastromina, I., Silva, J.C., Bjorklund, M., Seymour, P.A., Booth, D., Thompson, C., Green, R.J., Hall, E.A., Serup, P., and Dale, J.K. (2015). A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo. Development 142, 2291-2303, doi:10.1242/dev.125237.

Hanotel, J., Bessodes, N., Thelie, A., Hedderich, M., Parain, K., Van Driessche, B., Brandao Kde, O., Kricha, S., Jorgensen, M.C., Grapin-Botton, A., Serup, P., Van Lint, C., Perron, M., Pieler, T., Henningfeld, K.A., and Bellefroid, E.J. (2014). The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbpj downstream target that suppresses glutamatergic and promotes GABAergic neuronal fate in the dorsal neural tube. Developmental Biology 386, 340-357, doi:10.1016/j.ydbio.2013.12.024.

Seymour, P.A., and Serup, P. (2013). Bulking up on beta cells. New England Journal of Medicine 369, 777-779, doi:10.1056/NEJMcibr1307038.

Wolf, X.A., Klein, T., Garcia, R., Hyttel, P., and Serup, P. (2012). Identification of a conserved cis-acting region driving expression of mouse Eomesodermin to the primitive streak, node, and definitive endoderm. Gene Expression Patterns 12, 85-93, doi:10.1016/j.gep.2011.06.003.

Serup, P., Gustavsen, C., Klein, T., Potter, L.A., Lin, R., Mullapudi, N., Wandzioch, E., Hines, A., Davis, A., Bruun, C., Engberg, N., Petersen, D.R., Peterslund, J.M., Macdonald, R.J., Grapin-Botton, A., Magnuson, M.A., and Zaret, K.S. (2012). Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice. Disease Models and Mechanisms 5, 956-966, doi:10.1242/dmm.009696.

Serup, P. (2012a). Signaling pathways regulating murine pancreatic development. Seminars in Cell and Developmental Biology 23, 663-672, doi:10.1016/j.semcdb.2012.06.004.

Petersen, D.R., Gustavsen, C., Lindskog, S.R., Magnuson, M.A., Zaret, K.S., and Serup, P. (2012). Engineering artificial signaling centers to polarize embryoid body differentiation. Stem Cells and Development 21, 647-653, doi:10.1089/scd.2011.0344.

Kordowich, S., Serup, P., Collombat, P., and Mansouri, A. (2012). Generation of animals allowing the conditional inactivation of the Pax4 gene. Transgenic Research 21, 1215-1220, doi:10.1007/s11248-012-9624-0.

Serup, P. (2012). A step closer to making beta cells. Diabetologia 55, 540-541, doi:10.1007/s00125-011-2449-1.

Kalisz, M., Winzi, M., Bisgaard, H.C., and Serup, P. (2012). EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression. Developmental Biology 362, 94-103, doi:10.1016/j.ydbio.2011.11.017.

Horn, S., Kobberup, S., Jorgensen, M.C., Kalisz, M., Klein, T., Kageyama, R., Gegg, M., Lickert, H., Lindner, J., Magnuson, M.A., Kong, Y.Y., Serup, P., Ahnfelt-Ronne, J., and Jensen, J.N. (2012). Mind bomb 1 is required for pancreatic beta-cell formation. Proceedings of the National Academy of Sciences USA 109, 7356-7361, doi:10.1073/pnas.1203605109.

Ahnfelt-Ronne, J., Jorgensen, M.C., Klinck, R., Jensen, J.N., Fuchtbauer, E.M., Deering, T., MacDonald, R.J., Wright, C.V., Madsen, O.D., and Serup, P. (2012). Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. Development 139, 33-45, doi:10.1242/dev.071761.

Wolf, X.A., Serup, P., and Hyttel, P. (2011). Three-dimensional immunohistochemical characterization of lineage commitment by localization of T and FOXA2 in porcine peri-implantation embryos. Developmental Dynamics 240, 890-897, doi:10.1002/dvdy.22602.

Wolf, X.A., Serup, P., and Hyttel, P. (2011). Three-dimensional localisation of NANOG, OCT4, and E-CADHERIN in porcine pre- and peri-implantation embryos. Developmental Dynamics 240, 204-210, doi:10.1002/dvdy.22491.

Winzi, M.K., Hyttel, P., Dale, J.K., and Serup, P. (2011). Isolation and characterization of node/notochord-like cells from mouse embryonic stem cells. Stem Cells and Development 20, 1817-1827, doi:10.1089/scd.2011.0042.

Sylvestersen, K.B., Herrera, P.L., Serup, P., and Rescan, C. (2011). Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme. Gene Expression Patterns 11, 105-111, doi:10.1016/j.gep.2010.10.001.

Rubio-Cabezas, O., Jensen, J.N., Hodgson, M.I., Codner, E., Ellard, S., Serup, P., and Hattersley, A.T. (2011). Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3. Diabetes 60, 1349-1353, doi:10.2337/db10-1008.

Peterslund, J.M., and Serup, P. (2011). Activation of FGFR(IIIc) isoforms promotes activin-induced mesendoderm development in mouse embryonic stem cells and reduces Sox17 coexpression in EpCAM+ cells. Stem Cell Research 6, 262-275, doi:10.1016/j.scr.2011.02.003.

Kordowich, S., Collombat, P., Mansouri, A., and Serup, P. (2011). Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage. BMC Developmental Biology 11, 52, doi:10.1186/1471-213x-11-52.

Klinck, R., Fuchtbauer, E.M., Ahnfelt-Ronne, J., Serup, P., Jensen, J.N., and Jorgensen, M.C. (2011). A BAC transgenic Hes1-EGFP reporter reveals novel expression domains in mouse embryos. Gene Expression Patterns 11, 415-426, doi:10.1016/j.gep.2011.06.004.

Engberg, N., Kahn, M., Petersen, D.R., Hansson, M., and Serup, P. (2010). Retinoic acid synthesis promotes development of neural progenitors from mouse embryonic stem cells by suppressing endogenous, Wnt-dependent nodal signaling. Stem Cells 28, 1498-1509, doi:10.1002/stem.479.

Carlsson, G.L., Heller, R.S., Serup, P., and Hyttel, P. (2010). Immunohistochemistry of pancreatic development in cattle and pig. Anatomia Histologia Embryologia 39, 107-119, doi:10.1111/j.1439-0264.2009.00985.x.

Ahnfelt-Ronne, J., Ravassard, P., Pardanaud-Glavieux, C., Scharfmann, R., and Serup, P. (2010). Mesenchymal bone morphogenetic protein signaling is required for normal pancreas development. Diabetes 59, 1948-1956, doi:10.2337/db09-1010.

Rosenberg, L.C., Lafon, M.L., Pedersen, J.K., Yassin, H., Jensen, J.N., Serup, P., and Hecksher-Sorensen, J. (2010). The transcriptional activity of Neurog3 affects migration and differentiation of ectopic endocrine cells in chicken endoderm. Developmental Dynamics 239, 1950-1966, doi:10.1002/dvdy.22329.

Galbo, T., Pedersen, I.L., Floyel, T., Bang-Berthelsen, C.H., Serup, P., Madsen, O.D., and Hald, J. (2010). Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels. European Journal for Histochemistry 54, e19, doi:10.4081/ejh.2010.e19

Hansson, M., Olesen, D.R., Peterslund, J.M., Engberg, N., Kahn, M., Winzi, M., Klein, T., Maddox-Hyttel, P., and Serup, P. (2009). A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Developmental Biology 330, 286-304, doi:10.1016/j.ydbio.2009.03.026.

Collombat, P., Xu, X., Ravassard, P., Sosa-Pineda, B., Dussaud, S., Billestrup, N., Madsen, O.D., Serup, P., Heimberg, H., and Mansouri, A. (2009). The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 138, 449-462, doi:10.1016/j.cell.2009.05.035.

Bayha, E., Jorgensen, M.C., Serup, P., and Grapin-Botton, A. (2009). Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. Public Library of Science One 4, e5845, doi:10.1371/journal.pone.0005845.

Wang, S., Jensen, J.N., Seymour, P.A., Hsu, W., Dor, Y., Sander, M., Magnuson, M.A., Serup, P., and Gu, G. (2009). Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proceedings of the National Academy of Sciences USA 106, 9715-9720, doi:10.1073/pnas.0904247106.

Klein, T., Heremans, Y., Heimberg, H., Pipeleers, D., Madsen, O.D., Serup, P., and Heller, R.S. (2009). Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction. Pancreas 38, 36-48, doi:10.1097/MPA.0b013e3181816547.

Wang, S., Hecksher-Sorensen, J., Xu, Y., Zhao, A., Dor, Y., Rosenberg, L., Serup, P., and Gu, G. (2008). Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Developmental Biology 317, 531-540, doi:10.1016/j.ydbio.2008.02.052.

Klinck, R., Serup, P., Madsen, O.D., and Jorgensen, M.C. (2008). Specificity of four monoclonal anti-NKx6-1 antibodies. Journal of Histochemistry and Cytochemistry 56, 415-424, doi:10.1369/jhc.7A7350.2008.

Hald, J., Sprinkel, A.E., Ray, M., Serup, P., Wright, C., and Madsen, O.D. (2008). Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development. Journal of Histochemistry and Cytochemistry 56, 587-595, doi:10.1369/jhc.2008.950675.

Jensen, J.N., Rosenberg, L.C., Hecksher-Sorensen, J., and Serup, P. (2007). Mutant neurogenin-3 in congenital malabsorptive diarrhea. New England Journal of Medicine 356, 1781-1782; author reply 1782, doi:10.1056/NEJMc063247.

Collombat, P., Hecksher-Sorensen, J., Krull, J., Berger, J., Riedel, D., Herrera, P.L., Serup, P., and Mansouri, A. (2007). Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. Journal of Clinical Investigation 117, 961-970, doi:10.1172/jci29115.

Ahnfelt-Ronne, J., Jorgensen, M.C., Hald, J., Madsen, O.D., Serup, P., and Hecksher-Sorensen, J. (2007). An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs. Journal of Histochemistry and Cytochemistry 55, 925-930, doi:10.1369/jhc.7A7226.2007.

Ahnfelt-Ronne, J., Hald, J., Bodker, A., Yassin, H., Serup, P., and Hecksher-Sorensen, J. (2007). Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas. BMC Developmental Biology 7, doi:10.1186/1471-213x-7-63.

Jorgensen, M.C., Ahnfelt-Ronne, J., Hald, J., Madsen, O.D., Serup, P., and Hecksher-Sorensen, J. (2007). An illustrated review of early pancreas development in the mouse. Endocrinological Reviews 28, 685-705, doi:10.1210/er.2007-0016.

Taneera, J., Rosengren, A., Renstrom, E., Nygren, J.M., Serup, P., Rorsman, P., and Jacobsen, S.E. (2006). Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate. Diabetes 55, 290-296, doi: 10.2337/diabetes.55.02.06.db05-1212

Serup, P. (2006). Embryonic stem cell-based diabetes therapy--a long road to travel. Diabetologia 49, 2537-2540, doi:10.1007/s00125-006-0434-x.

Petri, A., Ahnfelt-Ronne, J., Frederiksen, K.S., Edwards, D.G., Madsen, D., Serup, P., Fleckner, J., and Heller, R.S. (2006). The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. Journal for Molecular Endocrinology 37, 301-316, doi:10.1677/jme.1.02096.

Madsen, O.D., and Serup, P. (2006). Towards cell therapy for diabetes. Nature Biotechnology 24, 1481-1483, doi:10.1038/nbt1206-1481.

Eldor, R., Yeffet, A., Baum, K., Doviner, V., Amar, D., Ben-Neriah, Y., Christofori, G., Peled, A., Carel, J.C., Boitard, C., Klein, T., Serup, P., Eizirik, D.L., and Melloul, D. (2006). Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents. Proceedings of the National Academy of Sciences USA 103, 5072-5077, doi:10.1073/pnas.0508166103.

Dichmann, D.S., Yassin, H., and Serup, P. (2006). Analysis of pancreatic endocrine development in GDF11-deficient mice. Developmental Dynamics 235, 3016-3025, doi:10.1002/dvdy.20953.

Collombat, P., Hecksher-Sorensen, J., Serup, P., and Mansouri, A. (2006). Specifying pancreatic endocrine cell fates. Mechanisms of Development 123, 501-512, doi:10.1016/j.mod.2006.05.006.

Pedersen, I.L., Klinck, R., Hecksher-Sorensen, J., Zahn, S., Madsen, O.D., Serup, P., and Jorgensen, M.C. (2006). Generation and characterization of monoclonal antibodies against the transcription factor Nkx6.1. Journal of Histochemistry and Cytochemistry 54, 567-574, doi:10.1369/jhc.5A6827.2006.

Pedersen, J.K., Nelson, S.B., Jorgensen, M.C., Henseleit, K.D., Fujitani, Y., Wright, C.V., Sander, M., and Serup, P. (2005). Endodermal expression of Nkx6 genes depends differentially on Pdx1. Developmental Biology 288, 487-501, doi:10.1016/j.ydbio.2005.10.001.

Collombat, P., Hecksher-Sorensen, J., Broccoli, V., Krull, J., Ponte, I., Mundiger, T., Smith, J., Gruss, P., Serup, P., and Mansouri, A. (2005). The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development 132, 2969-2980, doi:10.1242/dev.01870.

Heller, R.S., Jenny, M., Collombat, P., Mansouri, A., Tomasetto, C., Madsen, O.D., Mellitzer, G., Gradwohl, G., and Serup, P. (2005). Genetic determinants of pancreatic epsilon-cell development. Developmental Biology 286, 217-224, doi:10.1016/j.ydbio.2005.06.041.

Hecksher-Sorensen, J., Watson, R.P., Lettice, L.A., Serup, P., Eley, L., De Angelis, C., Ahlgren, U., and Hill, R.E. (2004). The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2. Development 131, 4665-4675, doi:10.1242/dev.01364.

Hansson, M., Tonning, A., Frandsen, U., Petri, A., Rajagopal, J., Englund, M.C., Heller, R.S., Hakansson, J., Fleckner, J., Skold, H.N., Melton, D., Semb, H., and Serup, P. (2004a). Artifactual insulin release from differentiated embryonic stem cells. Diabetes 53, 2603-2609, doi:10.2337/diabetes.53.10.2603.

Hansson, M., Tonning, A., Frandsen, U., Petri, A., Rajagopal, J., England, M.C.O., Heller, R.S., Håkansson, J., Fleckner, J., Skold, H.N., Melton, D., Semb, H., and Serup, P. (2004b). Artifactual insulin release from differentiated embryonic stem cells. Diabetes 53, 2603-2609, doi:10.2337/diabetes.53.10.2603.

Heller, R.S., Stoffers, D.A., Liu, A., Schedl, A., Crenshaw, E.B., 3rd, Madsen, O.D., and Serup, P. (2004). The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Developmental Biology 268, 123-134, doi:10.1016/j.ydbio.2003.12.008.

Zahn, S., Hecksher-Sorensen, J., Pedersen, I.L., Serup, P., and Madsen, O. (2004). Generation of monoclonal antibodies against mouse neurogenin 3: a new immunocytochemical tool to study the pancreatic endocrine progenitor cell. Hybridoma and Hybridomics 23, 385-388, doi:10.1089/hyb.2004.23.385.

Klein, T., Ling, Z., Heimberg, H., Madsen, O.D., Heller, R.S., and Serup, P. (2003). Nestin is expressed in vascular endothelial cells in the adult human pancreas. Journal of Histochemistry and Cytochemistry 51, 697-706, doi:10.1177/002215540305100601.

Heller, R.S., Klein, T., Ling, Z., Heimberg, H., Katoh, M., Madsen, O.D., and Serup, P. (2003). Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas. Gene Expression 11, 141-147.

Hald, J., Hjorth, J.P., German, M.S., Madsen, O.D., Serup, P., and Jensen, J. (2003). Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Developmental Biology 260, 426-437, doi: 10.1016/S0012-1606(03)00326-9

Gelling, R.W., Du, X.Q., Dichmann, D.S., Romer, J., Huang, H., Cui, L., Obici, S., Tang, B., Holst, J.J., Fledelius, C., Johansen, P.B., Rossetti, L., Jelicks, L.A., Serup, P., Nishimura, E., and Charron, M.J. (2003). Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proceedings of the National Academy of Sciences USA 100, 1438-1443, doi:10.1073/pnas.0237106100.

Dichmann, D.S., Rescan, C., Frandsen, U., and Serup, P. (2003). Unspecific labeling of pancreatic islets by antisera against fibroblast growth factors and their receptors. Journal of Histochemistry and Cytochemistry 51, 397-400, doi:10.1177/002215540305100314.

Collombat, P., Mansouri, A., Hecksher-Sorensen, J., Serup, P., Krull, J., Gradwohl, G., and Gruss, P. (2003). Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes and Development 17, 2591-2603, doi:10.1101/gad.269003.

Dichmann, D.S., Miller, C.P., Jensen, J., Scott Heller, R., and Serup, P. (2003). Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Developmental Dynamics 226, 663-674, doi:10.1002/dvdy.10270.

Petersen, H.V., Jensen, J.N., Stein, R., and Serup, P. (2002). Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization. Federation of European Biochemical Societies Letters 528, 241-245, doi: 10.1016/S0014-5793(02)03318-5

Heremans, Y., Van De Casteele, M., in't Veld, P., Gradwohl, G., Serup, P., Madsen, O., Pipeleers, D., and Heimberg, H. (2002). Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. Journal of Cell Biology 159, 303-312, doi:10.1083/jcb.200203074.

Heller, R.S., Dichmann, D.S., Jensen, J., Miller, C., Wong, G., Madsen, O.D., and Serup, P. (2002). Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Developmental Dynamics 225, 260-270, doi:10.1002/dvdy.10157.

Serup, P., Madsen, O.D., and Mandrup-Poulsen, T. (2001). Islet and stem cell transplantation for treating diabetes. British Medical Journal 322, 29-32, doi: 10.1136/bmj.322.7277.29.

Klein, T., Frandsen, U., Heller, R.S., and Serup, P. (2001). IMPAN cells: a pancreatic model for differentiation into endocrine cells. Archives of Biochemistry and Biophysics 395, 259-263, doi:10.1006/abbi.2001.2579.

Jessen, U., Novitskaya, V., Pedersen, N., Serup, P., Berezin, V., and Bock, E. (2001). The transcription factors CREB and c-Fos play key roles in NCAM-mediated neuritogenesis in PC12-E2 cells. Journal for Neurochemistry 79, 1149-1160, doi:10.1046/j.1471-4159.2001.00636.x.

Heller, R.S., Stoffers, D.A., Bock, T., Svenstrup, K., Jensen, J., Horn, T., Miller, C.P., Habener, J.F., Madsen, O.D., and Serup, P. (2001). Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas. Diabetes 50, 1553-1561, doi: 10.2337/diabetes.50.7.1553

Serup, P. (2000). Panning for pancreatic stem cells. Nature Genetics 25, 134-135, doi:10.1038/75960.

Petersen, H.V., Jorgensen, M.C., Andersen, F.G., Jensen, J., T, F.N., Jorgensen, R., Madsen, O.D., and Serup, P. (2000). Pax4 represses pancreatic glucagon gene expression. Molecular Cell Biology Research Communications 3, 249-254, doi:10.1006/mcbr.2000.0220.

Jensen, J., Pedersen, E.E., Galante, P., Hald, J., Heller, R.S., Ishibashi, M., Kageyama, R., Guillemot, F., Serup, P., and Madsen, O.D. (2000a). Control of endodermal endocrine development by Hes-1. Nature Genetics 24, 36-44, doi:10.1038/71657.

Jensen, J., Heller, R.S., Funder-Nielsen, T., Pedersen, E.E., Lindsell, C., Weinmaster, G., Madsen, O.D., and Serup, P. (2000). Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49, 163-176, doi:10.2337/diabetes.49.2.163

Hansen, L., Urioste, S., Petersen, H.V., Jensen, J.N., Eiberg, H., Barbetti, F., Serup, P., Hansen, T., and Pedersen, O. (2000). Missense mutations in the human insulin promoter factor-1 gene and their relation to maturity-onset diabetes of the young and late-onset type 2 diabetes mellitus in caucasians. The Journal of Clinical Endocrinology and Metabolism 85, 1323-1326, doi:10.1210/jcem.85.3.6421.

Ammendrup, A., Maillard, A., Nielsen, K., Aabenhus Andersen, N., Serup, P., Dragsbaek Madsen, O., Mandrup-Poulsen, T., and Bonny, C. (2000). The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. Diabetes 49, 1468-1476, doi: 10.2337/diabetes.49.9.1468.

Hansen, L., Jensen, J.N., Urioste, S., Petersen, H.V., Pociot, F., Eiberg, H., Kristiansen, O.P., Hansen, T., Serup, P., Nerup, J., and Pedersen, O. (2000). NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group. Diabetes 49, 876-878, doi:10.2337/diabetes.49.5.876.

Jorgensen, M.C., Vestergard Petersen, H., Ericson, J., Madsen, O.D., and Serup, P. (1999). Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1. Federation of European Biochemical Societies Letters 461, 287-294 doi: 1016/S0014-5793(99)01436-2.

Briscoe, J., Sussel, L., Serup, P., Hartigan-O'Connor, D., Jessell, T.M., Rubenstein, J.L., and Ericson, J. (1999). Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature 398, 622-627, doi:10.1038/19315.

Andersen, F.G., Jensen, J., Heller, R.S., Petersen, H.V., Larsson, L.I., Madsen, O.D., and Serup, P. (1999). Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer. Federation of European Biochemical Societies Letters 445, 315-320, doi:10.1016/S0014-5793(99)00144-1.

Andersen, F.G., Heller, R.S., Petersen, H.V., Jensen, J., Madsen, O.D., and Serup, P. (1999). Pax6 and Cdx2/3 form a functional complex on the rat glucagon gene promoter G1-element. Federation of European Biochemical Societies Letters 445, 306-310, doi:10.1016/S0014-5793(99)00145-3.

Nielsen, K., Karlsen, A.E., Deckert, M., Madsen, O.D., Serup, P., Mandrup-Poulsen, T., and Nerup, J. (1999). Beta-cell maturation leads to in vitro sensitivity to cytotoxins. Diabetes 48, 2324-2332, doi:10.2337/diabetes.48.12.2324.

Miralles, F., Serup, P., Cluzeaud, F., Vandewalle, A., Czernichow, P., and Scharfmann, R. (1999). Characterization of beta cells developed in vitro from rat embryonic pancreatic epithelium. Developmental Dynamics 214, 116-126, doi:10.1002/(sici)1097-0177(199902)214:2<116::aid-aja2>3.0.co;2-m.

Petersen, H.V., Peshavaria, M., Pedersen, A.A., Philippe, J., Stein, R., Madsen, O.D., and Serup, P. (1998). Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor. Federation of European Biochemical Societies Letters 431, 362-366, doi:10.1016/S0014-5793(98)00776-5.

Oster, A., Jensen, J., Serup, P., Galante, P., Madsen, O.D., and Larsson, L.I. (1998). Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). Journal of Histochemistry and Cytochemistry 46, 707-715, doi:10.1177/002215549804600602.

Madsen, O.D., Jensen, J., Petersen, H.V., Pedersen, E.E., Oster, A., Andersen, F.G., Jorgensen, M.C., Jensen, P.B., Larsson, L.I., and Serup, P. (1997). Transcription factors contributing to the pancreatic beta-cell phenotypeHormone and Metabolic Research 29, 265-270, doi:10.1055/s-2007-979035.

Corbett, J., Serup, P., Bonner-Weir, S., and Nielsen, J.H. (1997). Beta-cell ontogeny: growth and death. Diabetologia 40 Suppl 3, B27-32, doi:10.1007/BF03168183.

Madsen, O.D., Jensen, J., Blume, N., Petersen, H.V., Lund, K., Karlsen, C., Andersen, F.G., Jensen, P.B., Larsson, L.I., and Serup, P. (1996). Pancreatic development and maturation of the islet B cell. Studies of pluripotent islet cultures. European Journal for Biochemistry 242, 435-445, doi:10.1111/j.1432-1033.1996.435rr.x.

Larsson, L.I., Madsen, O.D., Serup, P., Jonsson, J., and Edlund, H. (1996). Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning. Mechansims of Development 60, 175-184, doi:10.1016/S0925-4773(96)00609-0.

Serup, P., Jensen, J., Andersen, F.G., Jorgensen, M.C., Blume, N., Holst, J.J., and Madsen, O.D. (1996). Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. Proceedings of the National Academy of Sciences USA 93, 9015-9020, doi: 10.1073/pnas.93.17.9015.

Galsgaard, E.D., Gouilleux, F., Groner, B., Serup, P., Nielsen, J.H., and Billestrup, N. (1996). Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene. Molecular Endocrinology 10, 652-660, doi:10.1210/mend.10.6.8776725.

Jensen, J., Serup, P., Karlsen, C., Nielsen, T.F., and Madsen, O.D. (1996). mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor. Journal of Biological Chemistry 271, 18749-18758, doi: 10.1074/jbc.271.31.18749.

Serup, P., Petersen, H.V., Pedersen, E.E., Edlund, H., Leonard, J., Petersen, J.S., Larsson, L.I., and Madsen, O.D. (1995). The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site. Biochemical Journal 310 ( Pt 3), 997-1003, doi: 10.1042/bj3100997.

Larsson, L.I., Tingstedt, J.E., Madsen, O.D., Serup, P., and Hougaard, D.M. (1995). The LIM-homeodomain protein Isl-1 segregates with somatostatin but not with gastrin expression during differentiation of somatostatin/gastrin precursor cells. Endocrine 3, 519-524, doi:10.1007/bf02738827.

Petersen, H.V., Serup, P., Leonard, J., Michelsen, B.K., and Madsen, O.D. (1994). Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Proceedings of the National Academy of Sciences USA 91, 10465-10469, doi:10.1073/pnas.91.22.10465.

Madsen, O.D., Serup, P., Karlsen, C., Lund, K., Petersen, H.V., Blume, N., Andersen, F.G., Jensen, J., and Michelsen, B.K. (1993). A tumour model for the study of islet cell differentiation. Biochemical Society Transactions 21, 142-146, doi:10.1042/bst0210142.

Blume, N., Petersen, J.S., Andersen, L.C., Kofod, H., Dyrberg, T., Michelsen, B.K., Serup, P., and Madsen, O.D. (1992). Immature transformed rat islet beta-cells differentially express C-peptides derived from the genes coding for insulin I and II as well as a transfected human insulin gene. Molecular Endocrinology 6, 299-307, doi:10.1210/mend.6.2.1569972.

Leonard, J., Serup, P., Gonzalez, G., Edlund, T., and Montminy, M. (1992). The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells. Proceedings of the National Academy of Sciences USA 89, 6247-6251, doi:10.1073/pnas.89.14.6247.

Michelsen, B., Dyrberg, T., Vissing, H., Serup, P., and Lernmark, A. (1990). HLA-DQ and -DX genes in insulin-dependent diabetes mellitus. Current Topics in Microbiological Immunology 164, 57-68, doi:10.1016/0165-2478(94)90133-3.

Billestrup, N., Moldrup, A., Serup, P., Mathews, L.S., Norstedt, G., and Nielsen, J.H. (1990). Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells. Proceedings of the National Academy of Sciences USA 87, 7210-7214, doi:10.1073/pnas.87.18.7210.

Serup, P., and Scholler, J. (1989). Transfected rat islet tumour cells express mouse major histocompatibility complex class I antigens functionally. Applicable as "pseudo-syngeneic" targets in the multiple low-dose streptozotocin diabetes model. Diabetologia 32, 409-415, doi:10.1007/BF00271259.